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    bmk-1 Kinesin-like protein [ Caenorhabditis elegans ]

    Gene ID: 179948, updated on 2-Nov-2024

    Summary

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    Official Symbol
    bmk-1
    Official Full Name
    Kinesin-like protein
    Primary source
    WormBase:WBGene00000257
    Locus tag
    CELE_F23B12.8
    See related
    AllianceGenome:WB:WBGene00000257
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable plus-end-directed microtubule motor activity. Involved in negative regulation of mitotic spindle elongation. Located in spindle midzone and spindle pole. Human ortholog(s) of this gene implicated in microcephaly with or without chorioretinopathy, lymphedema, or mental retardation. Orthologous to human KIF11 (kinesin family member 11). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See bmk-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    9
    Sequence:
    Chromosome: V; NC_003283.11 (14453302..14456984, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene Rad21/Rec8-like protein C-terminal eukaryotic domain-containing protein Neighboring gene SPerm CHromatin enriched

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome-wide RNAi screen for synthetic lethal interactions with the C. elegans kinesin-5 homolog BMK-1. Maia AF, et al. Sci Data, 2015. PMID 25984351, Free PMC Article
    2. Mitotic motors: kinesin-5 takes a brake. Civelekoglu-Scholey G, et al. Curr Biol, 2007 Jul 17. PMID 17637353
    3. Multiple motors cooperate to establish and maintain acentrosomal spindle bipolarity in C. elegans oocyte meiosis. Cavin-Meza G, et al. Elife, 2022 Feb 11. PMID 35147496, Free PMC Article
    4. Mitotic functions of kinesin-5. Ferenz NP, et al. Semin Cell Dev Biol, 2010 May. PMID 20109572, Free PMC Article
    5. Kinesin-5 acts as a brake in anaphase spindle elongation. Saunders AM, et al. Curr Biol, 2007 Jun 19. PMID 17580072, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The microtubule-bundling protein SPD-1/MAP-65 and BMK-1/kinesin-5 act as a brake opposing the force generated by the spindle midzone during Caenorhabditis elegans mitosis.
      Title: Chromatids segregate without centrosomes during Caenorhabditis elegans mitosis in a Ran- and CLASP-dependent manner.
    2. Kinesin-5 (Bmk-1)acts as rate-limiting brake for interpolar microtubule sliding.
      Title: Kinesin-5 acts as a brake in anaphase spindle elongation.
    3. deployed as a brake to slow down spindle-pole separation
      Title: Mitotic motors: kinesin-5 takes a brake.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cytoskeletal motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables plus-end-directed microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables plus-end-directed microtubule motor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in microtubule-based movement IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic spindle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of mitotic spindle elongation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spindle elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spindle organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitotic spindle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in spindle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in spindle microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in spindle midzone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in spindle pole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Kinesin-like protein
    NP_001256586.1
    • Confirmed by transcript evidence
    NP_001379525.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      14453302..14456984 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001392655.1 → NP_001379525.1  Kinesin-like protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5ECF4
      Conserved Domains (2) summary
      pfam15921
      Location:365 → 839
      CCDC158; Coiled-coil domain-containing protein 158
      cl22853
      Location:17 → 359
      Motor_domain; Myosin and Kinesin motor domain

    2. NM_001269657.2 → NP_001256586.1  Kinesin-like protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256586.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EGL7
      Conserved Domains (2) summary
      smart00129
      Location:13 → 352
      KISc; Kinesin motor, catalytic domain. ATPase
      cl22853
      Location:12 → 354
      Motor_domain; Myosin and Kinesin motor domain
    Nucleotide Protein
    Heading Accession and Version

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