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    rpb-2 DNA-directed RNA polymerase II subunit RPB2 [ Caenorhabditis elegans ]

    Gene ID: 175668, updated on 2-Nov-2024

    Summary

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    Official Symbol
    rpb-2
    Official Full Name
    DNA-directed RNA polymerase II subunit RPB2
    Primary source
    WormBase:WBGene00016140
    Locus tag
    CELE_C26E6.4
    See related
    AllianceGenome:WB:WBGene00016140
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable several functions, including DNA-directed 5'-3' RNA polymerase activity; metal ion binding activity; and ribonucleoside binding activity. Predicted to contribute to RNA polymerase II activity. Predicted to be involved in transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of RNA polymerase II, core complex. Is expressed in head; intestine; and tail. Orthologous to human POLR2B (RNA polymerase II subunit B). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See rpb-2 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    10
    Sequence:
    Chromosome: III; NC_003281.10 (4939567..4944404)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Large ribosomal subunit protein uL3m Neighboring gene F-box/SPRY domain-containing protein 1 Neighboring gene CCR4-NOT transcription complex subunit 9 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A Conserved Nuclear Cyclophilin Is Required for Both RNA Polymerase II Elongation and Co-transcriptional Splicing in Caenorhabditis elegans. Ahn JH, et al. PLoS Genet, 2016 Aug. PMID 27541139, Free PMC Article
    2. Loss of egli-1, the Caenorhabditis elegans Orthologue of a Downstream Target of SMN, Leads to Abnormalities in Sensorimotor Integration. Da Silva JD, et al. Mol Neurobiol, 2020 Mar. PMID 31797327
    3. Reprogramming of the transcriptome after heat stress mediates heat hormesis in Caenorhabditis elegans. Xu F, et al. Nat Commun, 2023 Jul 13. PMID 37443152, Free PMC Article
    4. Casein Kinase 1δ Stabilizes Mature Axons by Inhibiting Transcription Termination of Ankyrin. LaBella ML, et al. Dev Cell, 2020 Jan 6. PMID 31910362, Free PMC Article
    5. The Helicase Aquarius/EMB-4 Is Required to Overcome Intronic Barriers to Allow Nuclear RNAi Pathways to Heritably Silence Transcription. Akay A, et al. Dev Cell, 2017 Aug 7. PMID 28787591, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Our findings suggest that SIG-7 plays a central role in both Pol II elongation and co-transcriptional splicing and may provide an important link for their coordination and regulation
      Title: A Conserved Nuclear Cyclophilin Is Required for Both RNA Polymerase II Elongation and Co-transcriptional Splicing in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables 5'-3' RNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-directed 5'-3' RNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to RNA polymerase II activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribonucleoside binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of DNA-directed RNA polymerase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of RNA polymerase II, core complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DNA-directed RNA polymerase II subunit RPB2
    NP_498047.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      4939567..4944404
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_065646.8 → NP_498047.2  DNA-directed RNA polymerase II subunit RPB2 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q10578
      Conserved Domains (1) summary
      PRK08565
      Location:35 → 1183
      PRK08565; DNA-directed RNA polymerase subunit B; Provisional
    Nucleotide Protein
    Heading Accession and Version

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