nhr-112 Nuclear receptor domain-containing protein [Caenorhabditis elegans] - Gene

Summary

Official Symbol: nhr-112
Official Full Name: Nuclear receptor domain-containing protein
Primary source: WormBase:WBGene00003702
Locus tag: CELE_Y70C5C.6
See related: AllianceGenome:WB:WBGene00003702
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable DNA-binding transcription factor activity; sequence-specific DNA binding activity; and zinc ion binding activity. Involved in defense response to Gram-negative bacterium and innate immune response. Predicted to be located in nucleus. Is expressed in several structures, including head; hypodermis; pharynx; reproductive system; and tail. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease (multiple); hepatocellular carcinoma; lipid metabolism disorder; and type 2 diabetes mellitus. Orthologous to human PPARA (peroxisome proliferator activated receptor alpha) and PPARD (peroxisome proliferator activated receptor delta). [provided by Alliance of Genome Resources, Apr 2022]
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Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in defense response to Gram-negative bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in innate immune response	HEP more info	PubMed
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

NP_001024286.1

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