U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    tax-6 Serine/threonine-protein phosphatase 2B catalytic subunit [ Caenorhabditis elegans ]

    Gene ID: 177943, updated on 2-Nov-2024

    Summary

    Official Symbol
    tax-6
    Official Full Name
    Serine/threonine-protein phosphatase 2B catalytic subunit
    Primary source
    WormBase:WBGene00006527
    Locus tag
    CELE_C02F4.2
    See related
    AllianceGenome:WB:WBGene00006527
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables calcium ion binding activity and calmodulin-dependent protein phosphatase activity. Involved in several processes, including determination of adult lifespan; male mating behavior; and olfactory learning. Located in several cellular components, including dendrite; neuronal cell body; and non-motile cilium. Is expressed in several structures, including germ line; hypodermis; muscle cell; and nervous system. Human ortholog(s) of this gene implicated in aortic valve stenosis; developmental and epileptic encephalopathy 91; and schizophrenia. Orthologous to several human genes including PPP3CB (protein phosphatase 3 catalytic subunit beta) and PPP3CC (protein phosphatase 3 catalytic subunit gamma). [provided by Alliance of Genome Resources, Nov 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See tax-6 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    15
    Sequence:
    Chromosome: IV; NC_003282.8 (10492869..10501600, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Carboxypeptidase E Neighboring gene PHD-type domain-containing protein Neighboring gene Dedicator of cytokinesis protein 1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables calcium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables calmodulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables calmodulin-dependent protein phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calmodulin-dependent protein phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables calmodulin-dependent protein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphoprotein phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in behavior IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in calcineurin-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in calcineurin-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in calcium-mediated signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in chemosensory behavior IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in chemosensory behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chemotaxis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in dauer larval development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in endocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in hyperosmotic response IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in hyperosmotic response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in olfactory behavior IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in olfactory behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in olfactory learning IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in olfactory learning IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein localization to non-motile cilium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to alkaline pH IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to hermaphrodite contact IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in thermosensory behavior IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in thermosensory behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in thermotaxis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in thermotaxis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in vulval location IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
     
    part_of calcineurin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cilium IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in non-motile cilium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perikaryon IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    Serine/threonine-protein phosphatase 2B catalytic subunit
    NP_001076658.2
    • Confirmed by transcript evidence
    NP_001367052.1
    • Partially confirmed by transcript evidence
    NP_001379183.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      10492869..10501600 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001083189.5NP_001076658.2  Serine/threonine-protein phosphatase 2B catalytic subunit [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001076658.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0G819, Q86MD4, Q95002
      Conserved Domains (2) summary
      smart00156
      Location:83354
      PP2Ac; Protein phosphatase 2A homologues, catalytic domain
      cd07416
      Location:66370
      MPP_PP2B; PP2B, metallophosphatase domain
    2. NM_001392391.1NP_001379183.1  Serine/threonine-protein phosphatase 2B catalytic subunit [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      cd07416
      Location:66370
      MPP_PP2B; PP2B, metallophosphatase domain
    3. NM_001380448.1NP_001367052.1  Serine/threonine-protein phosphatase 2B catalytic subunit [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      cd07416
      Location:66370
      MPP_PP2B; PP2B, metallophosphatase domain