C18B12.4 RING-type domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: C18B12.4
Official Full Name: RING-type domain-containing protein
Primary source: WormBase:WBGene00007666
Locus tag: CELE_C18B12.4
See related: AllianceGenome:WB:WBGene00007666
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in ubiquitin-dependent protein catabolic process. Predicted to be located in membrane. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 73. Orthologous to human RNF13 (ring finger protein 13); RNF167 (ring finger protein 167); and ZNRF4 (zinc and ring finger 4). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See C18B12.4 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 9

Sequence:: Chromosome: X; NC_003284.9 (15036710..15040602, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C18B12B.2 (e-PCR)
- UniSTS:313714

C18B12.4 (e-PCR)
- UniSTS:317889

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: RING-type domain-containing protein

NP_510498.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

15036710..15040602 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_078097.6 → NP_510498.1 RING-type domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_510498.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9XX98

Conserved Domains (3) summary

COG5243
Location:223 → 335

HRD1; HRD ubiquitin ligase complex, ER membrane component [Posttranslational modification, protein turnover, chaperones]

cd16473
Location:246 → 291

RING-H2_RNF103; RING finger, H2 subclass, found in RING finger protein 103 (RNF103) and similar proteins

cl28883
Location:74 → 176

PA; Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain. At ...