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    mcm-7 DNA replication licensing factor MCM7 [ Caenorhabditis elegans ]

    Gene ID: 178831, updated on 2-Nov-2024

    Summary

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    Official Symbol
    mcm-7
    Official Full Name
    DNA replication licensing factor MCM7
    Primary source
    WormBase:WBGene00003159
    Locus tag
    CELE_F32D1.10
    See related
    AllianceGenome:WB:WBGene00003159
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable single-stranded DNA binding activity. Predicted to contribute to single-stranded DNA helicase activity. Involved in MCM complex assembly; embryo development; and mitotic sister chromatid segregation. Predicted to be part of MCM complex. Predicted to be active in nucleus. Is expressed in several structures, including anchor cell; intestine; pharynx; tail; and vulval precursor cell. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human MCM7 (minichromosome maintenance complex component 7). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See mcm-7 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    4
    Sequence:
    Chromosome: V; NC_003283.11 (4347166..4349768)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene AAA domain-containing protein;Fidgetin-like protein 1;Spastin/Vps4 C-terminal domain-containing protein Neighboring gene ATP synthase subunit epsilon, mitochondrial Neighboring gene TPR_REGION domain-containing protein;dolichyl-phosphate-mannose--protein mannosyltransferase Neighboring gene ncRNA Neighboring gene Ground-like domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Excess Mcm2-7 license dormant origins of replication that can be used under conditions of replicative stress. Woodward AM, et al. J Cell Biol, 2006 Jun 5. PMID 16754955, Free PMC Article
    2. TIMELESS-TIPIN and UBXN-3 promote replisome disassembly during DNA replication termination in Caenorhabditis elegans. Xia Y, et al. EMBO J, 2021 Sep 1. PMID 34269473, Free PMC Article
    3. Minichromosome maintenance protein 5 homologue in Caenorhabditis elegans plays essential role for postembryonic development. Wang X, et al. Biochem Biophys Res Commun, 2007 Aug 10. PMID 17568563
    4. Http://C. elegans: mining the functional genomic landscape. Kim SK. Nat Rev Genet, 2001 Sep. PMID 11533717
    5. The dynamics of replication licensing in live Caenorhabditis elegans embryos. Sonneville R, et al. J Cell Biol, 2012 Jan 23. PMID 22249291, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables single-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to single-stranded DNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA duplex unwinding IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA replication initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA replication initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA strand elongation involved in DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA unwinding involved in DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in MCM complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in double-strand break repair via break-induced replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in embryo development ending in birth or egg hatching IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mitotic sister chromatid segregation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of MCM complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of MCM complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of MCM complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in intracellular organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DNA replication licensing factor MCM7
    NP_504199.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      4347166..4349768
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_071798.9 → NP_504199.1  DNA replication licensing factor MCM7 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_504199.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O16297
      Conserved Domains (4) summary
      smart00350
      Location:162 → 651
      MCM; minichromosome maintenance proteins
      pfam14551
      Location:16 → 178
      MCM_N; MCM N-terminal domain
      cl00588
      Location:619 → 715
      CarD_CdnL_TRCF; CarD-like/TRCF domain
      cl21455
      Location:385 → 524
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein
    Heading Accession and Version

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