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    erfa-1 Eukaryotic peptide chain release factor subunit 1 [ Caenorhabditis elegans ]

    Gene ID: 179028, updated on 2-Nov-2024

    Summary

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    Official Symbol
    erfa-1
    Official Full Name
    Eukaryotic peptide chain release factor subunit 1
    Primary source
    WormBase:WBGene00020269
    Locus tag
    CELE_T05H4.6
    See related
    AllianceGenome:WB:WBGene00020269
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable sequence-specific mRNA binding activity and translation release factor activity, codon specific. Predicted to be involved in cytoplasmic translational termination. Predicted to be located in cytoplasm. Predicted to be part of translation release factor complex. Predicted to be active in cytosol. Orthologous to human ETF1 (eukaryotic translation termination factor 1). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See erfa-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    6
    Sequence:
    Chromosome: V; NC_003283.11 (6434130..6436402)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Aldehyde dehydrogenase Neighboring gene Gastrulation defective protein 1 Neighboring gene NADH-cytochrome b5 reductase Neighboring gene NADH-cytochrome b5 reductase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Proteomic analysis of Caenorhabditis elegans. Jeong PY, et al. Methods Mol Biol, 2009. PMID 19381582
    2. A genomewide RNAi screen for genes that affect the stability, distribution and function of P granules in Caenorhabditis elegans. Updike DL, et al. Genetics, 2009 Dec. PMID 19805813, Free PMC Article
    3. ABCE1 is a highly conserved RNA silencing suppressor. Kärblane K, et al. PLoS One, 2015. PMID 25659154, Free PMC Article
    4. CCAR-1 works together with the U2AF large subunit UAF-1 to regulate alternative splicing. Lugano DI, et al. RNA Biol, 2024 Jan. PMID 38126797, Free PMC Article
    5. SH3 interactome conserves general function over specific form. Xin X, et al. Mol Syst Biol, 2013. PMID 23549480, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables sequence-specific mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation release factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation release factor activity, codon specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoplasmic translational termination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translational termination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of translation release factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Eukaryotic peptide chain release factor subunit 1
    NP_001343671.1
    • Confirmed by transcript evidence
    NP_001380133.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      6434130..6436402
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001356664.2 → NP_001343671.1  Eukaryotic peptide chain release factor subunit 1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O16520, S6EZT6
      Conserved Domains (1) summary
      COG1503
      Location:19 → 426
      eRF1; Peptide chain release factor 1 (eRF1) [Translation, ribosomal structure and biogenesis]

    2. NM_001392531.1 → NP_001380133.1  Eukaryotic peptide chain release factor subunit 1 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      COG1503
      Location:19 → 426
      eRF1; Peptide chain release factor 1 (eRF1) [Translation, ribosomal structure and biogenesis]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O16520.3

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