kin-10 Casein kinase II subunit beta [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: kin-10
Official Full Name: Casein kinase II subunit beta
Primary source: WormBase:WBGene00002196
Locus tag: CELE_T01G9.6
See related: AllianceGenome:WB:WBGene00002196
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable protein kinase regulator activity. Involved in response to hermaphrodite contact and vulval location. Located in several cellular components, including dendrite; neuronal cell body; and non-motile cilium. Part of protein kinase CK2 complex. Is expressed in several structures, including germ cell; germ line; gonad; intestine; and vulva. Orthologous to human CSNK2B (casein kinase 2 beta). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See kin-10 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 6

Sequence:: Chromosome: I; NC_003279.8 (8288959..8291005, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Knockdown of kin-10 (casein kinase II subunit beta CK2beta) led to a short lifespan phenotype and induced age-related biomarkers, including retardation of locomotion, decreased pharyngeal pumping rate, increased lipofuscin accumulation.
Title: Downregulation of protein kinase CK2 activity induces age-related biomarkers in C. elegans.
Data show that DEAD-box RNA helicase, CGH-1/DDX6, as a key casein kinase II (CK2) substrate and phosphorylation of a conserved N-terminal serine is required for CGH-1 function in the microRNA (miRNA) pathway.
Title: Casein kinase II promotes target silencing by miRISC through direct phosphorylation of the DEAD-box RNA helicase CGH-1.
kin-10, which encodes the beta subunit of protein kinase CK2, is a novel factor regulating stem cell proliferation in the C. elegans germ line.
Title: Protein kinase CK2 both promotes robust proliferation and inhibits the proliferative fate in the C. elegans germ line.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T01G9.6 (e-PCR)
- UniSTS:318899

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase regulator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in behavior	IEA Inferred from Electronic Annotation more info
involved_in response to hermaphrodite contact	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vulval location	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in axon	IEA Inferred from Electronic Annotation more info
located_in cilium	IDA Inferred from Direct Assay more info	PubMed
located_in cilium	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in non-motile cilium	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	HDA more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in perikaryon	IEA Inferred from Electronic Annotation more info
part_of protein kinase CK2 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of protein kinase CK2 complex	IDA Inferred from Direct Assay more info	PubMed
part_of protein kinase CK2 complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Casein kinase II subunit beta

NP_001379151.1

Confirmed by transcript evidence

NP_001379152.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

8288959..8291005 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001392666.1 → NP_001379151.1 Casein kinase II subunit beta [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (1) summary

smart01085
Location:8 → 191

CK_II_beta; Casein kinase II regulatory subunit
NM_001392665.1 → NP_001379152.1 Casein kinase II subunit beta [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

O62352, P28548, Q22077

Conserved Domains (1) summary

smart01085
Location:8 → 190

CK_II_beta; Casein kinase II regulatory subunit