eps-8 SAM domain-containing protein;SH3 domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: eps-8
Official Full Name: SAM domain-containing protein;SH3 domain-containing protein
Primary source: WormBase:WBGene00001330
Locus tag: CELE_Y57G11C.24
See related: AllianceGenome:WB:WBGene00001330
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables actin filament binding activity. Involved in several processes, including barbed-end actin filament capping; cytoskeleton organization; and epidermis morphogenesis. Located in apical part of cell; brush border; and hemidesmosome. Is expressed in several structures, including P3.p hermaphrodite; P4.p hermaphrodite; P5.p hermaphrodite; hypodermis; and nervous system. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 102; autosomal recessive nonsyndromic deafness 106; and hypotrichosis 5. Orthologous to several human genes including EPS8L1 (EPS8 signaling adaptor L1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See eps-8 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 18

Sequence:: Chromosome: IV; NC_003282.8 (14879484..14900653)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

only one orthologue of the EPS8 gene exists, which gives rise to two alternatively spliced isoforms, EPS-8A and EPS-8B, differing at their carboxyl termini
Title: A novel actin barbed-end-capping activity in EPS-8 regulates apical morphogenesis in intestinal cells of Caenorhabditis elegans.
Results identify EGF receptor(EGFR) Let-23 substrate protein-8 (EPS-8) as a novel component of the EGFR localization complex that links receptor trafficking to cell fate specification.
Title: Cell fate-specific regulation of EGF receptor trafficking during Caenorhabditis elegans vulval development.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y57G11C.24 (e-PCR)
- UniSTS:318908

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables actin binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	IDA Inferred from Direct Assay more info	PubMed
enables cytoskeletal protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Rho protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin filament bundle assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in barbed-end actin filament capping	IDA Inferred from Direct Assay more info	PubMed
involved_in digestive tract morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in embryonic morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epidermis morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intermediate filament organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in maintenance of protein location	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nematode larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of Rho protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in apical part of cell	IDA Inferred from Direct Assay more info	PubMed
located_in brush border	IDA Inferred from Direct Assay more info	PubMed
located_in hemidesmosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: SAM domain-containing protein;SH3 domain-containing protein

NP_001023521.2

Confirmed by transcript evidence

NP_001023522.2

Confirmed by transcript evidence

NP_001041047.1

Confirmed by transcript evidence

NP_001041048.1

Confirmed by transcript evidence

NP_001293927.1

Confirmed by transcript evidence

NP_001293928.1

Confirmed by transcript evidence

NP_001293929.1

Confirmed by transcript evidence

NP_001293930.1

Confirmed by transcript evidence

NP_001293931.1

Confirmed by transcript evidence

NP_001360610.1

Confirmed by transcript evidence

NP_001360611.1

Confirmed by transcript evidence

NP_502803.3

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

14879484..14900653

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001047582.6 → NP_001041047.1 SH3 domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001041047.1

Status: REVIEWED

UniProtKB/TrEMBL

G5ED33

Conserved Domains (4) summary

cd11764
Location:608 → 661

SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins

cd01210
Location:99 → 230

PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

pfam11600
Location:485 → 549

CAF-1_p150; Chromatin assembly factor 1 complex p150 subunit, N-terminal

pfam18016
Location:812 → 871

SAM_3; SAM domain (Sterile alpha motif)
NM_001047583.7 → NP_001041048.1 SH3 domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001041048.1

Status: REVIEWED

UniProtKB/TrEMBL

G5EFE0

Conserved Domains (3) summary

cd11764
Location:633 → 686

SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins

cd01210
Location:99 → 230

PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

pfam11600
Location:525 → 574

CAF-1_p150; Chromatin assembly factor 1 complex p150 subunit, N-terminal
NM_001306998.2 → NP_001293927.1 SH3 domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001293927.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A061ACP8

Conserved Domains (4) summary

cd11764
Location:633 → 686

SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins

cd01210
Location:99 → 230

PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

pfam11600
Location:525 → 574

CAF-1_p150; Chromatin assembly factor 1 complex p150 subunit, N-terminal

pfam18016
Location:837 → 896

SAM_3; SAM domain (Sterile alpha motif)
NM_001372963.2 → NP_001360610.1 SH3 domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A4V6M3U0

Conserved Domains (4) summary

cd11764
Location:634 → 687

SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins

cd01210
Location:100 → 231

PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

pfam11600
Location:526 → 575

CAF-1_p150; Chromatin assembly factor 1 complex p150 subunit, N-terminal

pfam18016
Location:838 → 897

SAM_3; SAM domain (Sterile alpha motif)
NM_001372964.2 → NP_001360611.1 SH3 domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A4V0IJW4

Conserved Domains (4) summary

cd11764
Location:609 → 662

SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins

cd01210
Location:100 → 231

PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

pfam11600
Location:486 → 550

CAF-1_p150; Chromatin assembly factor 1 complex p150 subunit, N-terminal

pfam18016
Location:813 → 872

SAM_3; SAM domain (Sterile alpha motif)
NM_070402.6 → NP_502803.3 SH3 domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_502803.3

Status: REVIEWED

UniProtKB/TrEMBL

O18250

Conserved Domains (4) summary

cd11764
Location:553 → 606

SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins

cd01210
Location:44 → 175

PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

pfam11600
Location:430 → 494

CAF-1_p150; Chromatin assembly factor 1 complex p150 subunit, N-terminal

pfam18016
Location:757 → 816

SAM_3; SAM domain (Sterile alpha motif)
NM_001306999.3 → NP_001293928.1 SH3 domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001293928.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A061ADW6

Conserved Domains (4) summary

cd11764
Location:578 → 631

SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins

cd01210
Location:44 → 175

PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

pfam11600
Location:470 → 519

CAF-1_p150; Chromatin assembly factor 1 complex p150 subunit, N-terminal

pfam18016
Location:782 → 841

SAM_3; SAM domain (Sterile alpha motif)
NM_001307000.3 → NP_001293929.1 SH3 domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001293929.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A061ACM2

Conserved Domains (4) summary

cd11764
Location:561 → 614

SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins

cd01210
Location:27 → 158

PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

pfam11600
Location:453 → 502

CAF-1_p150; Chromatin assembly factor 1 complex p150 subunit, N-terminal

pfam18016
Location:765 → 824

SAM_3; SAM domain (Sterile alpha motif)
NM_001028350.6 → NP_001023521.2 SH3 domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001023521.2

Status: REVIEWED

UniProtKB/TrEMBL

Q7YTG1

Conserved Domains (4) summary

cd11764
Location:536 → 589

SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins

cd01210
Location:27 → 158

PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

pfam11600
Location:413 → 477

CAF-1_p150; Chromatin assembly factor 1 complex p150 subunit, N-terminal

pfam18016
Location:740 → 799

SAM_3; SAM domain (Sterile alpha motif)
NM_001028351.5 → NP_001023522.2 SH3 domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001023522.2

Status: REVIEWED

UniProtKB/TrEMBL

Q7YTG2

Conserved Domains (3) summary

cd11764
Location:356 → 409

SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins

pfam11600
Location:233 → 297

CAF-1_p150; Chromatin assembly factor 1 complex p150 subunit, N-terminal

pfam18016
Location:560 → 619

SAM_3; SAM domain (Sterile alpha motif)
NM_001307001.3 → NP_001293930.1 SH3 domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001293930.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A061AJ42

Conserved Domains (3) summary

cd11764
Location:381 → 434

SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins

pfam11600
Location:273 → 322

CAF-1_p150; Chromatin assembly factor 1 complex p150 subunit, N-terminal

pfam18016
Location:585 → 644

SAM_3; SAM domain (Sterile alpha motif)
NM_001307002.3 → NP_001293931.1 SAM domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001293931.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A061AKT4

Conserved Domains (1) summary

pfam18016
Location:74 → 133

SAM_3; SAM domain (Sterile alpha motif)