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    unc-58 Potassium channel domain-containing protein;Uncoordinated protein 58 [ Caenorhabditis elegans ]

    Gene ID: 181224, updated on 2-Nov-2024

    Summary

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    Official Symbol
    unc-58
    Official Full Name
    Potassium channel domain-containing protein;Uncoordinated protein 58
    Primary source
    WormBase:WBGene00006792
    Locus tag
    CELE_T06H11.1
    See related
    AllianceGenome:WB:WBGene00006792
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables outward rectifier potassium channel activity. Involved in several processes, including muscle contraction; parturition; and regulation of muscle contraction. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in interneuron and motor neurons. Orthologous to human KCNK17 (potassium two pore domain channel subfamily K member 17) and KCNK5 (potassium two pore domain channel subfamily K member 5). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See unc-58 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    22
    Sequence:
    Chromosome: X; NC_003284.9 (10104610..10133182, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene glutamate synthase (NADH) Neighboring gene SPREPIRF-amide Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tRNA-Ser Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tRNA-Arg Neighboring gene ncRNA Neighboring gene tRNA-Arg Neighboring gene MoaB/Mog domain-containing protein Neighboring gene Nose resistant-to-fluoxetine protein N-terminal domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Clozapine, nimodipine and endosulfan differentially suppress behavioral defects caused by gain-of-function mutations in a two-pore domain K(+) channel (UNC-58). Kasap M, et al. Neurosci Res, 2021 Sep. PMID 32681854
    2. Radiation-induced genomic instability in Caenorhabditis elegans. Huumonen K, et al. Mutat Res, 2012 Oct 9. PMID 22796420
    3. Confounds of using the unc-58 selection marker highlights the importance of genotyping co-CRISPR genes. Rawsthorne-Manning H, et al. PLoS One, 2022. PMID 35041685, Free PMC Article
    4. Mutants of a temperature-sensitive two-P domain potassium channel. Kunkel MT, et al. J Neurosci, 2000 Oct 15. PMID 11027209, Free PMC Article
    5. Isolation of null alleles of the Caenorhabditis elegans gly-12, gly-13 and gly-14 genes, all of which encode UDP-GlcNAc: alpha-3-D-mannoside beta1,2-N-acetylglucosaminyltransferase I activity. Chen S, et al. Biochimie, 2003 Mar-Apr. PMID 12770777

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables outward rectifier potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables outward rectifier potassium channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables potassium ion leak channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in locomotion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in muscle contraction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in parturition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of muscle contraction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Potassium channel domain-containing protein;Uncoordinated protein 58
    NP_001360790.1
    • Confirmed by transcript evidence
    NP_001360791.1
    • Partially confirmed by transcript evidence
    NP_001360792.1
    • Partially confirmed by transcript evidence
    NP_001360793.1
    • Partially confirmed by transcript evidence
    NP_001360794.1
    • Confirmed by transcript evidence
    NP_741880.1
    • Confirmed by transcript evidence
    NP_741881.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      10104610..10133182 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_171759.6 → NP_741881.1  Uncoordinated protein 58 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741881.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q22271, Q8MPX9
      Conserved Domains (1) summary
      pfam07885
      Location:284 → 344
      Ion_trans_2; Ion channel

    2. NM_001373458.4 → NP_001360790.1  Potassium channel domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4V0IKM3
      Conserved Domains (1) summary
      pfam07885
      Location:211 → 267
      Ion_trans_2; Ion channel

    3. NM_001373459.2 → NP_001360794.1  Potassium channel domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4V0INP7
      Conserved Domains (1) summary
      pfam07885
      Location:207 → 263
      Ion_trans_2; Ion channel

    4. NM_001373460.3 → NP_001360792.1  Potassium channel domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4V0IL39
      Conserved Domains (1) summary
      pfam07885
      Location:184 → 240
      Ion_trans_2; Ion channel

    5. NM_001373456.2 → NP_001360793.1  Potassium channel domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4V0INX3
      Conserved Domains (1) summary
      pfam07885
      Location:299 → 355
      Ion_trans_2; Ion channel

    6. NM_171758.5 → NP_741880.1  Uncoordinated protein 58 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741880.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q22271
      Conserved Domains (1) summary
      pfam07885
      Location:246 → 306
      Ion_trans_2; Ion channel

    7. NM_001373457.2 → NP_001360791.1  Potassium channel domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4V0IKI8
      Conserved Domains (1) summary
      pfam07885
      Location:259 → 315
      Ion_trans_2; Ion channel
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q22271.2

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