lov-1 Location of vulva defective 1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: lov-1
Official Full Name: Location of vulva defective 1
Primary source: WormBase:WBGene00003058
Locus tag: CELE_ZK945.9
See related: AllianceGenome:WB:WBGene00003058
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables protein domain specific binding activity. Involved in response to hermaphrodite contact and vulval location. Located in neuronal cell body and non-motile cilium. Is expressed in male. Used to study autosomal dominant polycystic kidney disease. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See lov-1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 32

Sequence:: Chromosome: II; NC_003280.10 (10109100..10121825, complement)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tracking N- and C-termini of C. elegans polycystin-1 reveals their distinct targeting requirements and functions in cilia and extracellular vesicles.
Title: Tracking N- and C-termini of C. elegans polycystin-1 reveals their distinct targeting requirements and functions in cilia and extracellular vesicles.
expressed in male-specific neurons, required for mating
Title: Polycystic Kidney Disease: Lessons Learned from Caenorhabditis elegans Mating Behavior.
These data reveal that the STAM-Hrs complex, which down-regulates ligand-activated growth factor receptors from the cell surface of yeast and mammalian cells, also regulates the localization and signaling of a ciliary PC1 receptor-TRPP2 complex.
Title: STAM and Hrs down-regulate ciliary TRP receptors.
lov-1 is required for two male sensory behaviors: response and vulva location. It is a close homolog of human PKD1 and is localized in the same neurons as worm PKD-2, suggesting a common pathway.
Title: A polycystic kidney-disease gene homologue required for male mating behaviour in C. elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ZK945.10 (e-PCR)
- UniSTS:311651

ZK945.9 (e-PCR)
- UniSTS:308335

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables calcium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in behavior	IEA Inferred from Electronic Annotation more info
involved_in calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in detection of mechanical stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in male mating behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mating behavior	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mating behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to hermaphrodite contact	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vulval location	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cilium	IDA Inferred from Direct Assay more info	PubMed
located_in cilium	IEA Inferred from Electronic Annotation more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in non-motile cilium	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Location of vulva defective 1

NP_496184.3

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

10109100..10121825 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_063783.4 → NP_496184.3 Location of vulva defective 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_496184.3

Status: REVIEWED

UniProtKB/Swiss-Prot

Q09624, Q09625, Q969D4

Conserved Domains (3) summary

smart00303
Location:2177 → 2226

GPS; G-protein-coupled receptor proteolytic site domain

cd01752
Location:2288 → 2413

PLAT_polycystin; PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological ...

pfam08016
Location:2723 → 3175

PKD_channel; Polycystin cation channel