rab-6.2 Ras-related protein rab-6.2 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: rab-6.2
Official Full Name: Ras-related protein rab-6.2
Primary source: WormBase:WBGene00004270
Locus tag: CELE_T25G12.4
See related: AllianceGenome:WB:WBGene00004270
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables GTP binding activity. Involved in several processes, including early endosome to Golgi transport; positive regulation of feeding behavior; and protein stabilization. Located in Golgi trans cisterna. Is expressed in several structures, including alimentary muscle; hypodermis; nervous system; pharynx; and reproductive system. Orthologous to several human genes including RAB6A (RAB6A, member RAS oncogene family) and RAB6B (RAB6B, member RAS oncogene family). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See rab-6.2 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 6

Sequence:: Chromosome: X; NC_003284.9 (17222475..17224465)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RAB-6.2 and LIN-10 recycle AMPARs along a retrograde transport pathway in neurons so as to maintain synaptic strength.
Title: RAB-6.2 and the retromer regulate glutamate receptor recycling through a retrograde pathway.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T25G12.4 (e-PCR)
- UniSTS:319682

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTP binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in adult locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cuticle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in early endosome to Golgi transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intra-Golgi vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in mechanosensory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of feeding behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to postsynaptic membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein stabilization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of AMPA receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in retrograde transport, endosome to Golgi	IBA Inferred from Biological aspect of Ancestor more info
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	IMP Inferred from Mutant Phenotype more info	PubMed
located_in Golgi cisterna	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi trans cisterna	IDA Inferred from Direct Assay more info	PubMed
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
is_active_in endomembrane system	IBA Inferred from Biological aspect of Ancestor more info
located_in perikaryon	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Ras-related protein rab-6.2

NP_510790.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

17222475..17224465

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_078389.7 → NP_510790.1 Ras-related protein rab-6.2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_510790.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q22782

UniProtKB/TrEMBL

I7FW36

Conserved Domains (2) summary

smart00175
Location:11 → 168

RAB; Rab subfamily of small GTPases

cd01861
Location:11 → 171

Rab6; Rab GTPase family 6 (Rab6)