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    sec-61.B Protein transport protein Sec61 subunit beta [ Caenorhabditis elegans ]

    Gene ID: 177027, updated on 2-Nov-2024

    Summary

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    Official Symbol
    sec-61.B
    Official Full Name
    Protein transport protein Sec61 subunit beta
    Primary source
    WormBase:WBGene00021427
    Locus tag
    CELE_Y38F2AR.9
    See related
    AllianceGenome:WB:WBGene00021427
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in SRP-dependent cotranslational protein targeting to membrane, translocation and post-translational protein targeting to membrane, translocation. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of Sec61 translocon complex. Predicted to be active in membrane. Orthologous to human SEC61B (SEC61 translocon subunit beta). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See sec-61.B in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    2
    Sequence:
    Chromosome: IV; NC_003282.8 (2388185..2388675, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Transcription Factor ThreeC subunit (GTF3C homolog) Neighboring gene Complex I assembly factor TIMMDC1, mitochondrial;Transmembrane protein;Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Translocon-associated protein subunit gamma

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sec61β facilitates the maintenance of endoplasmic reticulum homeostasis by associating microtubules. Zhu Y, et al. Protein Cell, 2018 Jul. PMID 29168059, Free PMC Article
    2. Alternative redox forms of ASNA-1 separate insulin signaling from tail-anchored protein targeting and cisplatin resistance in C. elegans. Raj D, et al. Sci Rep, 2021 Apr 21. PMID 33883621, Free PMC Article
    3. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
    4. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    5. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in SRP-dependent cotranslational protein targeting to membrane, translocation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in post-translational protein targeting to membrane, translocation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Sec61 translocon complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Sec61 translocon complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Protein transport protein Sec61 subunit beta
    NP_500197.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      2388185..2388675 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067796.9 → NP_500197.1  Protein transport protein Sec61 subunit beta [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_500197.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95XS2
      Conserved Domains (1) summary
      pfam03911
      Location:36 → 73
      Sec61_beta; Sec61beta family
    Nucleotide Protein
    Heading Accession and Version

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