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    GIT2 GIT ArfGAP 2 [ Homo sapiens (human) ]

    Gene ID: 9815, updated on 2-Nov-2024

    Summary

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    Official Symbol
    GIT2provided by HGNC
    Official Full Name
    GIT ArfGAP 2provided by HGNC
    Primary source
    HGNC:HGNC:4273
    See related
    Ensembl:ENSG00000139436 MIM:608564; AllianceGenome:HGNC:4273
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PKL; CAT2; CAT-2
    Summary
    This gene encodes a member of the GIT protein family, which interact with G protein-coupled receptor kinases and possess ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity. GIT proteins traffic between cytoplasmic complexes, focal adhesions, and the cell periphery, and interact with Pak interacting exchange factor beta (PIX) to form large oligomeric complexes that transiently recruit other proteins. GIT proteins regulate cytoskeletal dynamics and participate in receptor internalization and membrane trafficking. This gene has been shown to repress lamellipodial extension and focal adhesion turnover, and is thought to regulate cell motility. This gene undergoes extensive alternative splicing to generate multiple isoforms, but the full-length nature of some of these variants has not been determined. The various isoforms have functional differences, with respect to ARF GAP activity and to G protein-coupled receptor kinase 2 binding. [provided by RefSeq, Sep 2008]
    Expression
    Ubiquitous expression in spleen (RPKM 15.0), lymph node (RPKM 13.1) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See GIT2 in Genome Data Viewer
    Location:
    12q24.11
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (109929804..110000164, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (109905496..109975853, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (110367609..110434173, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 441, pseudogene Neighboring gene glycolipid transfer protein Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4845 Neighboring gene uncharacterized LOC124903012 Neighboring gene NANOG hESC enhancer GRCh37_chr12:110318928-110319429 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4846 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4847 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:110337802-110338642 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr12:110338643-110339483 Neighboring gene trichoplein keratin filament binding Neighboring gene ReSE screen-validated silencer GRCh37_chr12:110353916-110354160 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:110358257-110358757 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:110361416-110362271 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:110362776-110363756 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:110363757-110364736 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr12:110370433-110371632 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:110384533-110385204 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:110385205-110385876 Neighboring gene uncharacterized LOC124903013 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6987 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4849 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6988 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6989 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4850 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4851 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6990 Neighboring gene Sharpr-MPRA regulatory region 2512 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6991 Neighboring gene ankyrin repeat domain 13A Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:110460576-110461076 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6992 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr12:110465819-110467018 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:110480304-110480817 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4852 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6993 Neighboring gene chromosome 12 open reading frame 76 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6994 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6995 Neighboring gene CRISPRi-validated cis-regulatory element chr12.3588 Neighboring gene uncharacterized LOC105369976 Neighboring gene Sharpr-MPRA regulatory region 13461

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. GIT2 deficiency attenuates inflammation-induced expression of pro-labor mediators in human amnion and myometrial cells†. Lim R, et al. Biol Reprod, 2019 Jun 1. PMID 30915469
    2. GIT proteins, A novel family of phosphatidylinositol 3,4, 5-trisphosphate-stimulated GTPase-activating proteins for ARF6. Vitale N, et al. J Biol Chem, 2000 May 5. PMID 10788515
    3. Angiotensin converting enzyme inhibitors attenuated the expression of G-protein coupled receptor kinases in heart failure patients. Oyama N, et al. Circ J, 2006 Mar. PMID 16501306
    4. The multifunctional GIT family of proteins. Hoefen RJ, et al. J Cell Sci, 2006 Apr 15. PMID 16598076
    5. An ADP-ribosylation factor GTPase-activating protein Git2-short/KIAA0148 is involved in subcellular localization of paxillin and actin cytoskeletal organization. Mazaki Y, et al. Mol Biol Cell, 2001 Mar. PMID 11251077, Free PMC Article

    See all (74) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Genetic architecture of the inflammatory bowel diseases across East Asian and European ancestries.
      Title: Genetic architecture of the inflammatory bowel diseases across East Asian and European ancestries.
    2. Long non-coding RNA MALAT1 promotes odontogenic differentiation of human dental pulp stem cells by impairing microRNA-140-5p-dependent downregulation of GIT2.
      Title: Long non-coding RNA MALAT1 promotes odontogenic differentiation of human dental pulp stem cells by impairing microRNA-140-5p-dependent downregulation of GIT2.
    3. GIT2 deficiency attenuates inflammation-induced expression of pro-labor mediators in human amnion and myometrial cellsdagger.
      Title: GIT2 deficiency attenuates inflammation-induced expression of pro-labor mediators in human amnion and myometrial cells†.
    4. our work identifies DOCK5 as a key regulator of epithelial invasion and metastasis, and demonstrates that suppression of DOCK5 by GIT2 represents a previously unappreciated mechanism for coordination of Rho and Rac GTPases.
      Title: The focal adhesion-associated proteins DOCK5 and GIT2 comprise a rheostat in control of epithelial invasion.
    5. we discuss recent findings in key physiological systems that exemplify current understanding of the function of this important regulatory complex. Further, we draw attention to gaps in crucial information that remain to be filled to allow a better understanding of the many roles of the GIT-PIX complex in health and disease
      Title: Expanding functions of GIT Arf GTPase-activating proteins, PIX Rho guanine nucleotide exchange factors and GIT-PIX complexes.
    6. Short-term EGF stimulation if of lung tumor cells can increase the interaction between RUSC2 and GIT2, prolonged stimulation leads to a decrease of their interaction through activating Rab35.
      Title: EGF-stimulated activation of Rab35 regulates RUSC2-GIT2 complex formation to stabilize GIT2 during directional lung cancer cell migration.
    7. GIT2 plays an important role in MRE11/ATM/H2AX-mediated DNA damage responses.
      Title: Nuclear GIT2 is an ATM substrate and promotes DNA repair.
    8. ADMA and L-arginine are substrates of human CAT2A, CAT2B, OCT2 and MATE1. Transport kinetics of CAT2A, CAT2B, and OCT2 indicate a low affinity, high capacity transport, which may be relevant for renal and hepatic elimination of ADMA or L-arginine
      Title: Transport of asymmetric dimethylarginine (ADMA) by cationic amino acid transporter 2 (CAT2), organic cation transporter 2 (OCT2) and multidrug and toxin extrusion protein 1 (MATE1).
    9. Zeb1 is regulated by the Arf GTPase-activating protein (GAP) Git2.
      Title: Loss of Git2 induces epithelial-mesenchymal transition by miR146a-Cnot6L-controlled expression of Zeb1.
    10. The expression level of lymphocyte GRK might show the severity of CHF, and ACEI treatment could reduce the level of GRK in CHF patients.
      Title: Angiotensin converting enzyme inhibitors attenuated the expression of G-protein coupled receptor kinases in heart failure patients.
    Submit: New GeneRIF Correction See all GeneRIFs (14)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide association study of the metabolic syndrome in Indian Asian men.
    EBI GWAS Catalog
    Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC760, KIAA0148, DKFZp686G01261

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in brain development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of ARF protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synaptic vesicle recycling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in focal adhesion HDA PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in presynapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ARF GTPase-activating protein GIT2
    Names
    ARF GAP GIT2
    G protein-coupled receptor kinase interacting ArfGAP 2
    G protein-coupled receptor kinase-interactor 2
    GRK-interacting protein 2
    Paxillin kinase linker
    cool-associated, tyrosine phosphorylated protein 2
    cool-interacting tyrosine-phosphorylated protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029885.1 RefSeqGene

      Range
      5022..71586
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001135213.3 → NP_001128685.1  ARF GTPase-activating protein GIT2 isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks two in-frame exons in the 3' coding region and includes an additional short in-frame exon in the central coding region, compared to isoform 1. The resulting isoform (6) is missing two internal fragments and includes a 2 residue insertion, compared to isoform 1.
      Source sequence(s)
      AA813937, BP871813, D63482
      Consensus CDS
      CCDS55884.1
      UniProtKB/TrEMBL
      R4GNG3
      Related
      ENSP00000391813.2, ENST00000457474.6
      Conserved Domains (5) summary
      sd00045
      Location:137 → 165
      ANK; ANK repeat [structural motif]
      cd08847
      Location:1 → 111
      ArfGap_GIT2; GIT2 GTPase activating protein for Arf
      pfam08518
      Location:268 → 296
      GIT_SHD; Spa2 homology domain (SHD) of GIT
      pfam12205
      Location:563 → 674
      GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
      pfam12796
      Location:137 → 229
      Ank_2; Ankyrin repeats (3 copies)

    2. NM_001135214.3 → NP_001128686.1  ARF GTPase-activating protein GIT2 isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks one in-frame exon in the 3' coding region, compared to variant 1. The resulting isoform (5) is missing one fragment but has the same N- and C-termini as isoform 1.
      Source sequence(s)
      AA813937, AF124491, BP871813, CR749340, D63482
      Consensus CDS
      CCDS44968.1
      UniProtKB/TrEMBL
      R4GNG3
      Related
      ENSP00000354282.5, ENST00000361006.9
      Conserved Domains (7) summary
      smart00105
      Location:2 → 124
      ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
      cd00204
      Location:109 → 220
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam08518
      Location:266 → 294
      GIT_SHD; Spa2 homology domain (SHD) of GIT
      pfam12205
      Location:608 → 722
      GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
      pfam12796
      Location:137 → 229
      Ank_2; Ankyrin repeats (3 copies)
      pfam16559
      Location:414 → 478
      GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor
      sd00045
      Location:137 → 165
      ANK; ANK repeat [structural motif]

    3. NM_001330153.2 → NP_001317082.1  ARF GTPase-activating protein GIT2 isoform 7

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) uses an alternate in-frame splice site and lacks an alternate in-frame exon in the 5' coding region compared to variant 1. The resulting isoform (7) is shorter but has the same N- and C-termini as isoform 1.
      Source sequence(s)
      AA813937, AF124491, BE646544, BP871813, CR980157, D63482
      Consensus CDS
      CCDS81736.1
      UniProtKB/TrEMBL
      F8VXI9, R4GNG3
      Related
      ENSP00000448832.1, ENST00000551209.5
      Conserved Domains (6) summary
      smart00105
      Location:2 → 124
      ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
      cd00204
      Location:109 → 220
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam08518
      Location:265 → 293
      GIT_SHD; Spa2 homology domain (SHD) of GIT
      pfam12205
      Location:587 → 701
      GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
      pfam12796
      Location:137 → 229
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:137 → 165
      ANK; ANK repeat [structural motif]

    4. NM_001330154.2 → NP_001317083.1  ARF GTPase-activating protein GIT2 isoform 8

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) lacks most 3' exons and has an alternate exon at the 3' end, as compared to variant 1. Isoform 8 is much shorter and has a different C-terminus than isoform 1.
      Source sequence(s)
      AC084876, AK222736, BM557270, BP871813
      Consensus CDS
      CCDS81737.1
      UniProtKB/TrEMBL
      B4E2E7, F8W822
      Related
      ENSP00000323833.9, ENST00000320063.10
      Conserved Domains (4) summary
      smart00105
      Location:2 → 124
      ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
      cd00204
      Location:109 → 220
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:137 → 165
      ANK; ANK repeat [structural motif]
      pfam08518
      Location:266 → 293
      GIT_SHD; Spa2 homology domain (SHD) of GIT

    5. NM_014776.5 → NP_055591.2  ARF GTPase-activating protein GIT2 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks two exons in the coding region, as compared to variant 1. Isoform 3 is missing two fragments but has the same N- and C-termini as isoform 1.
      Source sequence(s)
      AA813937, AF124491, BP871813, D63482
      UniProtKB/TrEMBL
      R4GNG3
      Conserved Domains (6) summary
      smart00105
      Location:2 → 124
      ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
      cd00204
      Location:109 → 220
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam08518
      Location:266 → 294
      GIT_SHD; Spa2 homology domain (SHD) of GIT
      pfam12205
      Location:558 → 672
      GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
      pfam12796
      Location:137 → 229
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:137 → 165
      ANK; ANK repeat [structural motif]

    6. NM_057169.5 → NP_476510.1  ARF GTPase-activating protein GIT2 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AA813937, AF124491, BP871813, D63482
      Consensus CDS
      CCDS9138.1
      UniProtKB/Swiss-Prot
      Q14161, Q86U59, Q96CI2, Q9BV91, Q9Y5V2
      UniProtKB/TrEMBL
      R4GNG3
      Related
      ENSP00000347464.3, ENST00000355312.8
      Conserved Domains (7) summary
      smart00105
      Location:2 → 124
      ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
      cd00204
      Location:109 → 220
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam08518
      Location:266 → 294
      GIT_SHD; Spa2 homology domain (SHD) of GIT
      pfam12205
      Location:638 → 752
      GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
      pfam12796
      Location:137 → 229
      Ank_2; Ankyrin repeats (3 copies)
      pfam16559
      Location:414 → 478
      GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor
      sd00045
      Location:137 → 165
      ANK; ANK repeat [structural motif]

    7. NM_057170.5 → NP_476511.1  ARF GTPase-activating protein GIT2 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks two exons and a portion of a third exon in the coding region, as compared to variant 1. The reading frame is maintained. Isoform 2 is missing internal 128 aa but has the same N- and C-termini as isoform 1.
      Source sequence(s)
      AA813937, AK308304, BC014223, BP871813, D63482
      Consensus CDS
      CCDS44969.1
      UniProtKB/TrEMBL
      R4GNG3
      Related
      ENSP00000447465.1, ENST00000553118.5
      Conserved Domains (6) summary
      smart00105
      Location:2 → 124
      ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
      cd00204
      Location:109 → 220
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:137 → 165
      ANK; ANK repeat [structural motif]
      pfam08518
      Location:266 → 293
      GIT_SHD; Spa2 homology domain (SHD) of GIT
      pfam12205
      Location:510 → 624
      GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
      pfam16559
      Location:414 → 450
      GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor

    8. NM_139201.3 → NP_631940.2  ARF GTPase-activating protein GIT2 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks most 3' exons and has an alternate exon at the 3' end, as compared to variant 1. Isoform 4 is much shorter and has a different C-terminus than isoform 1.
      Source sequence(s)
      AC084876, AK222736, BM557270, BP871813
      Consensus CDS
      CCDS9139.1
      UniProtKB/TrEMBL
      B5BU58, Q6FI58
      Related
      ENSP00000450348.1, ENST00000547815.5
      Conserved Domains (6) summary
      sd00045
      Location:137 → 165
      ANK; ANK repeat [structural motif]
      cd08847
      Location:1 → 111
      ArfGap_GIT2; GIT2 GTPase activating protein for Arf
      pfam08518
      Location:266 → 294
      GIT_SHD; Spa2 homology domain (SHD) of GIT
      pfam12796
      Location:137 → 229
      Ank_2; Ankyrin repeats (3 copies)
      pfam16559
      Location:414 → 465
      GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor
      pfam14203
      Location:246 → 284
      TTRAP; Putative tranposon-transfer assisting protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      109929804..110000164 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047429924.1 → XP_047285880.1  ARF GTPase-activating protein GIT2 isoform X8

    2. XM_047429926.1 → XP_047285882.1  ARF GTPase-activating protein GIT2 isoform X10

    3. XM_047429925.1 → XP_047285881.1  ARF GTPase-activating protein GIT2 isoform X9

    4. XM_017020258.3 → XP_016875747.1  ARF GTPase-activating protein GIT2 isoform X6

      UniProtKB/TrEMBL
      R4GNG3

    5. XM_047429922.1 → XP_047285878.1  ARF GTPase-activating protein GIT2 isoform X3

    6. XM_047429923.1 → XP_047285879.1  ARF GTPase-activating protein GIT2 isoform X4

    7. XM_005253997.5 → XP_005254054.1  ARF GTPase-activating protein GIT2 isoform X1

      UniProtKB/TrEMBL
      R4GNG3
      Conserved Domains (7) summary
      smart00105
      Location:2 → 124
      ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
      cd00204
      Location:109 → 220
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam08518
      Location:265 → 293
      GIT_SHD; Spa2 homology domain (SHD) of GIT
      pfam12205
      Location:637 → 751
      GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
      pfam12796
      Location:137 → 229
      Ank_2; Ankyrin repeats (3 copies)
      pfam16559
      Location:413 → 477
      GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor
      sd00045
      Location:137 → 165
      ANK; ANK repeat [structural motif]

    8. XM_006719712.5 → XP_006719775.1  ARF GTPase-activating protein GIT2 isoform X11

      Conserved Domains (6) summary
      smart00105
      Location:2 → 124
      ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
      cd00204
      Location:109 → 220
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam08518
      Location:266 → 294
      GIT_SHD; Spa2 homology domain (SHD) of GIT
      pfam12205
      Location:475 → 589
      GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
      pfam12796
      Location:137 → 229
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:137 → 165
      ANK; ANK repeat [structural motif]

    9. XM_006719709.5 → XP_006719772.1  ARF GTPase-activating protein GIT2 isoform X7

      UniProtKB/TrEMBL
      R4GNG3
      Conserved Domains (6) summary
      smart00105
      Location:2 → 124
      ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
      cd00204
      Location:109 → 220
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam08518
      Location:266 → 294
      GIT_SHD; Spa2 homology domain (SHD) of GIT
      pfam12205
      Location:588 → 702
      GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
      pfam12796
      Location:137 → 229
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:137 → 165
      ANK; ANK repeat [structural motif]

    10. XM_006719708.5 → XP_006719771.1  ARF GTPase-activating protein GIT2 isoform X5

      UniProtKB/TrEMBL
      R4GNG3
      Conserved Domains (7) summary
      smart00105
      Location:2 → 124
      ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
      cd00204
      Location:109 → 220
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam08518
      Location:266 → 294
      GIT_SHD; Spa2 homology domain (SHD) of GIT
      pfam12205
      Location:593 → 707
      GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
      pfam12796
      Location:137 → 229
      Ank_2; Ankyrin repeats (3 copies)
      pfam16559
      Location:414 → 463
      GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor
      sd00045
      Location:137 → 165
      ANK; ANK repeat [structural motif]

    11. XM_006719707.5 → XP_006719770.1  ARF GTPase-activating protein GIT2 isoform X2

      UniProtKB/TrEMBL
      R4GNG3
      Conserved Domains (7) summary
      smart00105
      Location:2 → 124
      ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
      cd00204
      Location:109 → 220
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam08518
      Location:266 → 294
      GIT_SHD; Spa2 homology domain (SHD) of GIT
      pfam12205
      Location:623 → 737
      GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
      pfam12796
      Location:137 → 229
      Ank_2; Ankyrin repeats (3 copies)
      pfam16559
      Location:414 → 463
      GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor
      sd00045
      Location:137 → 165
      ANK; ANK repeat [structural motif]

    12. XM_047429928.1 → XP_047285884.1  ARF GTPase-activating protein GIT2 isoform X15

    13. XM_047429927.1 → XP_047285883.1  ARF GTPase-activating protein GIT2 isoform X14

    14. XM_017020261.3 → XP_016875750.1  ARF GTPase-activating protein GIT2 isoform X12

      UniProtKB/TrEMBL
      B5BU58

    15. XM_006719713.5 → XP_006719776.1  ARF GTPase-activating protein GIT2 isoform X13

      UniProtKB/TrEMBL
      B5BU58
      Conserved Domains (6) summary
      smart00105
      Location:2 → 124
      ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
      cd00204
      Location:109 → 220
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam08518
      Location:266 → 294
      GIT_SHD; Spa2 homology domain (SHD) of GIT
      pfam12796
      Location:137 → 229
      Ank_2; Ankyrin repeats (3 copies)
      pfam16559
      Location:414 → 449
      GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor
      sd00045
      Location:137 → 165
      ANK; ANK repeat [structural motif]

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      109905496..109975853 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054373915.1 → XP_054229890.1  ARF GTPase-activating protein GIT2 isoform X8

    2. XM_054373917.1 → XP_054229892.1  ARF GTPase-activating protein GIT2 isoform X10

    3. XM_054373916.1 → XP_054229891.1  ARF GTPase-activating protein GIT2 isoform X9

    4. XM_054373913.1 → XP_054229888.1  ARF GTPase-activating protein GIT2 isoform X6

    5. XM_054373910.1 → XP_054229885.1  ARF GTPase-activating protein GIT2 isoform X3

    6. XM_054373911.1 → XP_054229886.1  ARF GTPase-activating protein GIT2 isoform X4

    7. XM_054373908.1 → XP_054229883.1  ARF GTPase-activating protein GIT2 isoform X1

    8. XM_054373918.1 → XP_054229893.1  ARF GTPase-activating protein GIT2 isoform X11

    9. XM_054373914.1 → XP_054229889.1  ARF GTPase-activating protein GIT2 isoform X7

    10. XM_054373912.1 → XP_054229887.1  ARF GTPase-activating protein GIT2 isoform X5

    11. XM_054373909.1 → XP_054229884.1  ARF GTPase-activating protein GIT2 isoform X2

    12. XM_054373922.1 → XP_054229897.1  ARF GTPase-activating protein GIT2 isoform X15

    13. XM_054373921.1 → XP_054229896.1  ARF GTPase-activating protein GIT2 isoform X14

    14. XM_054373919.1 → XP_054229894.1  ARF GTPase-activating protein GIT2 isoform X12

    15. XM_054373920.1 → XP_054229895.1  ARF GTPase-activating protein GIT2 isoform X13

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q14161.2 GenPept UniProtKB/Swiss-Prot:Q14161

    Gene LinkOut

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