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    PRKX protein kinase cAMP-dependent X-linked catalytic subunit [ Homo sapiens (human) ]

    Gene ID: 5613, updated on 14-Nov-2024

    Summary

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    Official Symbol
    PRKXprovided by HGNC
    Official Full Name
    protein kinase cAMP-dependent X-linked catalytic subunitprovided by HGNC
    Primary source
    HGNC:HGNC:9441
    See related
    Ensembl:ENSG00000183943 MIM:300083; AllianceGenome:HGNC:9441
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PKX1
    Summary
    This gene encodes a serine threonine protein kinase that has similarity to the catalytic subunit of cyclic AMP dependent protein kinases. The encoded protein is developmentally regulated and may be involved in renal epithelial morphogenesis. This protein may also be involved in macrophage and granulocyte maturation. Abnormal recombination between this gene and a related pseudogene on chromosome Y is a frequent cause of sex reversal disorder in XX males and XY females. Pseudogenes of this gene are found on chromosomes X, 15 and Y. [provided by RefSeq, Feb 2010]
    Expression
    Broad expression in thyroid (RPKM 22.9), kidney (RPKM 7.3) and 20 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See PRKX in Genome Data Viewer
    Location:
    Xp22.33
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (3604340..3713649, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (3218669..3333048, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (3522381..3631690, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA, H/ACA box 48B Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chrX:3470673-3471624 Neighboring gene RNA, U6 small nuclear 114, pseudogene Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:3509707-3510638 Neighboring gene RNA, U6 small nuclear 146, pseudogene Neighboring gene PRKX antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 13686 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29374 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chrX:3620023-3620624 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:3629037-3629558 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29375 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29376 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20640 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20641 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20642 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:3632955-3633602 Neighboring gene RPS27A pseudogene 20 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chrX:3650386-3651585 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20643 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20644 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29377 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20645 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20646 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20647 Neighboring gene uncharacterized LOC124900487 Neighboring gene zinc finger protein 839 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. PRKX, a Novel cAMP-Dependent Protein Kinase Member, Plays an Important Role in Development. Huang S, et al. J Cell Biochem, 2016 Mar. PMID 26252946
    2. PRKX, a phylogenetically and functionally distinct cAMP-dependent protein kinase, activates renal epithelial cell migration and morphogenesis. Li X, et al. Proc Natl Acad Sci U S A, 2002 Jul 9. PMID 12082174, Free PMC Article
    3. Gene conversion between the X chromosome and the male-specific region of the Y chromosome at a translocation hotspot. Rosser ZH, et al. Am J Hum Genet, 2009 Jul. PMID 19576564, Free PMC Article
    4. The human protein kinase gene PKX1 on Xp22.3 displays Xp/Yp homology and is a site of chromosomal instability. Klink A, et al. Hum Mol Genet, 1995 May. PMID 7633447
    5. Abnormal XY interchange between a novel isolated protein kinase gene, PRKY, and its homologue, PRKX, accounts for one third of all (Y+)XX males and (Y-)XY females. Schiebel K, et al. Hum Mol Genet, 1997 Oct. PMID 9302280

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PRKX, WNT3 and WNT16 genes, belonging to the WNT signaling pathway, are involved in the tumorigenic process of nodular basal cell carcinoma
      Title: Altered Expression of PRKX, WNT3 and WNT16 in Human Nodular Basal Cell Carcinoma.
    2. The characteristics and developmental functions of PRKX. [review]
      Title: PRKX, a Novel cAMP-Dependent Protein Kinase Member, Plays an Important Role in Development.
    3. findings reveals a major role of PRKX, TTBK2 and RSK4 in triggering Sunitinib resistance formation; data suggest transcriptional regulation of these kinases together with other proteins might play an important role in formation of Sunitinib resistance by affecting transcription factors
      Title: PRKX, TTBK2 and RSK4 expression causes Sunitinib resistance in kidney carcinoma- and melanoma-cell lines.
    4. MBD 4--a potential substrate for protein kinase X
      Title: MBD 4--a potential substrate for protein kinase X.
    5. The interaction of PRKX with Pin-1, Magi-1 and Bag-3 could contribute to the stimulating role of PRKX in angiogenesis.
      Title: PRKX critically regulates endothelial cell proliferation, migration, and vascular-like structure formation.
    6. PRKX can restore normal function to PKD1-deficient kidneys and have implications for the development of preventative therapy for autosomal dominant polycystic kidney disease
      Title: Protein kinase X (PRKX) can rescue the effects of polycystic kidney disease-1 gene (PKD1) deficiency.
    7. PRKX kinase may regulate epithelial morphogenesis during mammalian kidney development.
      Title: PRKX, a phylogenetically and functionally distinct cAMP-dependent protein kinase, activates renal epithelial cell migration and morphogenesis.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of protein kinase, X-linked (PRKX) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cAMP-dependent protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cAMP-dependent protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell-substrate adhesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endothelial cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endothelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in epithelial tube morphogenesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in kidney morphogenesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in myeloid cell differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of cell adhesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of cell migration IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of epithelial cell differentiation involved in kidney development IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of cAMP-dependent protein kinase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cAMP-dependent protein kinase catalytic subunit PRKX
    Names
    protein kinase PKX1
    protein kinase X
    protein kinase X-linked
    serine/threonine-protein kinase PRKX
    NP_005035.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016716.1 RefSeqGene

      Range
      4986..114295
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_005044.5 → NP_005035.1  cAMP-dependent protein kinase catalytic subunit PRKX

      See identical proteins and their annotated locations for NP_005035.1

      Status: REVIEWED

      Source sequence(s)
      AC007685, BC041073, BE675757, DN997580
      Consensus CDS
      CCDS14125.1
      UniProtKB/Swiss-Prot
      P51817
      Related
      ENSP00000262848.5, ENST00000262848.6
      Conserved Domains (2) summary
      PTZ00263
      Location:39 → 358
      PTZ00263; protein kinase A catalytic subunit; Provisional
      cd05612
      Location:47 → 338
      STKc_PRKX_like; Catalytic domain of PRKX-like Protein Serine/Threonine Kinases

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      3604340..3713649 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      3218669..3333048 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P51817.1 GenPept UniProtKB/Swiss-Prot:P51817

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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