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FGFR2 fibroblast growth factor receptor 2 [ Homo sapiens (human) ]

Gene ID: 2263, updated on 14-Nov-2024

Summary

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Official Symbol: FGFR2provided by HGNC
Official Full Name: fibroblast growth factor receptor 2provided by HGNC
Primary source: HGNC:HGNC:3689
See related: Ensembl:ENSG00000066468 MIM:176943; AllianceGenome:HGNC:3689
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: BEK; JWS; BBDS; CEK3; CFD1; ECT1; KGFR; TK14; TK25; BFR-1; CD332; K-SAM
Summary: The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009]
Expression: Broad expression in skin (RPKM 22.1), thyroid (RPKM 14.8) and 20 other tissues See more
Orthologs: mouse all
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Genomic context

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See FGFR2 in Genome Data Viewer

Location:: 10q26.13

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	10	NC_000010.11 (121478330..121598458, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	10	NC_060934.1 (122374405..122494614, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	10	NC_000010.10 (123237844..123357958, complement)

Chromosome 10 - NC_000010.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Expression of fibroblast growth factor receptor 2 (FGFR2) in combined hepatocellular-cholangiocarcinoma and intrahepatic cholangiocarcinoma: clinicopathological study.
Title: Expression of fibroblast growth factor receptor 2 (FGFR2) in combined hepatocellular-cholangiocarcinoma and intrahepatic cholangiocarcinoma: clinicopathological study.
Perinatal imaging findings of a fetus with Pfeiffer syndrome and a heterozygous c.1019A>G, p.Tyr340Cys (Y340C) mutation in FGFR2 presenting a cloverleaf skull, craniosynostosis and short limbs on prenatal ultrasound mimicking thanatophoric dysplasia type II.
Title: Perinatal imaging findings of a fetus with Pfeiffer syndrome and a heterozygous c.1019A>G, p.Tyr340Cys (Y340C) mutation in FGFR2 presenting a cloverleaf skull, craniosynostosis and short limbs on prenatal ultrasound mimicking thanatophoric dysplasia type II.
Elucidating the Role of Wildtype and Variant FGFR2 Structural Dynamics in (Dys)Function and Disorder.
Title: Elucidating the Role of Wildtype and Variant FGFR2 Structural Dynamics in (Dys)Function and Disorder.
Superficial acral calcified chondroid mesenchymal neoplasm harboring an FN1::FGFR2 fusion and review of the literature.
Title: Superficial acral calcified chondroid mesenchymal neoplasm harboring an FN1::FGFR2 fusion and review of the literature.
Genetic insights into the 'sandwich fusion' subtype of Klippel-Feil syndrome: novel FGFR2 mutations identified by 21 cases of whole-exome sequencing.
Title: Genetic insights into the 'sandwich fusion' subtype of Klippel-Feil syndrome: novel FGFR2 mutations identified by 21 cases of whole-exome sequencing.
Expansion of the complex genotypic and phenotypic spectrum of FGFR2-associated neurocutaneous syndromes.
Title: Expansion of the complex genotypic and phenotypic spectrum of FGFR2-associated neurocutaneous syndromes.
Investigating FGFR2 gene as a blood-based epigenetic biomarker in gastric cancer.
Title: Investigating FGFR2 gene as a blood-based epigenetic biomarker in gastric cancer.
FGFR2 genetic variants in women with breast cancer.
Title: FGFR2 genetic variants in women with breast cancer.
Facial skeleton dysmorphology in syndromic craniosynostosis: differences between FGFR2 and no-FGFR2-related syndromes and relationship with skull base and facial sutural patterns.
Title: Facial skeleton dysmorphology in syndromic craniosynostosis: differences between FGFR2 and no-FGFR2-related syndromes and relationship with skull base and facial sutural patterns.
miRNA-381-3p Functions as a Tumor Suppressor to Inhibit Gastric Cancer by Targeting Fibroblast Growth Factor Receptor-2.
Title: miRNA-381-3p Functions as a Tumor Suppressor to Inhibit Gastric Cancer by Targeting Fibroblast Growth Factor Receptor-2.

Submit: New GeneRIF Correction See all GeneRIFs (530)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Acrocephalosyndactyly type I MedGen: C0001193 OMIM: 101200 GeneReviews: FGFR Craniosynostosis Syndromes Overview, Apert Syndrome	not available
Antley-Bixler syndrome without genital anomalies or disordered steroidogenesis MedGen: C2936791 OMIM: 207410 GeneReviews: Cytochrome P450 Oxidoreductase Deficiency	not available
Beare-Stevenson cutis gyrata syndrome MedGen: C1852406 OMIM: 123790 GeneReviews: FGFR Craniosynostosis Syndromes Overview	not available
Bent bone dysplasia syndrome 1 MedGen: C3281247 OMIM: 614592 GeneReviews: FGFR Craniosynostosis Syndromes Overview	not available
Crouzon syndrome MedGen: C0010273 OMIM: 123500 GeneReviews: FGFR Craniosynostosis Syndromes Overview	not available
Familial scaphocephaly syndrome, McGillivray type MedGen: C1865070 OMIM: 609579 GeneReviews: Not available	not available
Gastric cancer MedGen: C0024623 OMIM: 613659 GeneReviews: Not available	not available
Isolated coronal synostosis MedGen: CN043619 GeneReviews: FGFR Craniosynostosis Syndromes Overview	not available
Jackson-Weiss syndrome MedGen: C0795998 OMIM: 123150 GeneReviews: FGFR Craniosynostosis Syndromes Overview	not available
LADD syndrome 1 MedGen: C5774323 OMIM: 149730 GeneReviews: Not available	not available
Pemigatinib response MedGen: CN297576 GeneReviews: Not available	not available
Pfeiffer syndrome MedGen: C0220658 OMIM: 101600 GeneReviews: FGFR Craniosynostosis Syndromes Overview	not available
Saethre-Chotzen syndrome MedGen: C0175699 OMIM: 101400 GeneReviews: Saethre-Chotzen Syndrome	not available

EBI GWAS Catalog

Description
A combined analysis of genome-wide association studies in breast cancer. EBI GWAS Catalog EBI GWAS CatalogPubMed
A genome-wide association study identifies a genetic variant in the SIAH2 locus associated with hormonal receptor-positive breast cancer in Japanese. EBI GWAS Catalog EBI GWAS CatalogPubMed
A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer. EBI GWAS Catalog EBI GWAS CatalogPubMed
A genome-wide association study of early-onset breast cancer identifies PFKM as a novel breast cancer gene and supports a common genetic spectrum for breast cancer at any age. EBI GWAS Catalog EBI GWAS CatalogPubMed
A meta-analysis of genome-wide association studies for adiponectin levels in East Asians identifies a novel locus near WDR11-FGFR2. EBI GWAS Catalog EBI GWAS CatalogPubMed
A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1). EBI GWAS Catalog EBI GWAS CatalogPubMed
Common genetic variants and modification of penetrance of BRCA2-associated breast cancer. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genetic correction of PSA values using sequence variants associated with PSA levels. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genetic variants associated with breast cancer risk for Ashkenazi Jewish women with strong family histories but no identifiable BRCA1/2 mutation. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study identifies five new breast cancer susceptibility loci. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study identifies novel breast cancer susceptibility loci. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study of breast cancer in the Japanese population. EBI GWAS Catalog EBI GWAS CatalogPubMed
Large-scale genotyping identifies 41 new loci associated with breast cancer risk. EBI GWAS Catalog EBI GWAS CatalogPubMed
Novel breast cancer susceptibility locus at 9q31.2: results of a genome-wide association study. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See Variation Viewer (GRCh37.p13)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC20217P1 (e-PCR)
- UniSTS:271885

G15912 (e-PCR)
- UniSTS:12306

WI-16392 (e-PCR)
- UniSTS:63005

Fgfr2 (e-PCR), detects polymorphism
- UniSTS:464672

D10S1483 (e-PCR), detects polymorphism
- UniSTS:23589

GDB:435442 (e-PCR)
- UniSTS:157226

FGFR2 (e-PCR)
- UniSTS:480054

Fgfr2 (e-PCR), detects polymorphism
- UniSTS:547904

RH66427 (e-PCR)
- UniSTS:82513

RH11106 (e-PCR)
- UniSTS:7252

G17445 (e-PCR)
- UniSTS:11093

FGFR2_647.2 (e-PCR)
- UniSTS:468057

RH123626 (e-PCR)
- UniSTS:136045

D1S1425 (e-PCR)
- UniSTS:149621

GDB:193861 (e-PCR)
- UniSTS:155769

Fgfr2 (e-PCR), detects polymorphism
- UniSTS:464790

GDB:335751 (e-PCR)
- UniSTS:156601

L29953 (e-PCR)
- UniSTS:52164

D10S2163 (e-PCR)
- UniSTS:18638

RH17739 (e-PCR)
- UniSTS:72918

GDB:554771 (e-PCR)
- UniSTS:157658

GDB:554776 (e-PCR)
- UniSTS:157659

SHGC-16531 (e-PCR)
- UniSTS:18158

D10S2143 (e-PCR)
- UniSTS:3056

Fgfr2 (e-PCR), detects polymorphism
- UniSTS:547827

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables GPI-linked ephrin receptor activity	IEA Inferred from Electronic Annotation more info
enables boss receptor activity	IEA Inferred from Electronic Annotation more info
enables brain-derived neurotrophic factor receptor activity	IEA Inferred from Electronic Annotation more info
enables epidermal growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables fibroblast growth factor binding	IBA Inferred from Biological aspect of Ancestor more info
enables fibroblast growth factor binding	IDA Inferred from Direct Assay more info	PubMed
enables fibroblast growth factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables fibroblast growth factor receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables fibroblast growth factor receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables fibroblast growth factor receptor activity	IGI Inferred from Genetic Interaction more info	PubMed
enables fibroblast growth factor receptor activity	NAS Non-traceable Author Statement more info	PubMed
enables heparin binding	IEA Inferred from Electronic Annotation more info
enables hepatocyte growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXY142 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3Y41 kinase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables insulin receptor activity	IEA Inferred from Electronic Annotation more info
enables insulin-like growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables macrophage colony-stimulating factor receptor activity	IEA Inferred from Electronic Annotation more info
enables placental growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables platelet-derived growth factor alpha-receptor activity	IEA Inferred from Electronic Annotation more info
enables platelet-derived growth factor beta-receptor activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables protein tyrosine kinase activity	NAS Non-traceable Author Statement more info	PubMed
enables protein tyrosine kinase collagen receptor activity	IEA Inferred from Electronic Annotation more info
enables stem cell factor receptor activity	IEA Inferred from Electronic Annotation more info
enables transmembrane-ephrin receptor activity	IEA Inferred from Electronic Annotation more info
enables vascular endothelial growth factor receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Kit signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in angiogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in animal organ morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in axonogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in bone development	ISS Inferred from Sequence or Structural Similarity more info
involved_in bone mineralization	ISS Inferred from Sequence or Structural Similarity more info
involved_in bone morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in brain-derived neurotrophic factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in branch elongation involved in salivary gland morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in branching involved in labyrinthine layer morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in branching involved in prostate gland morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in branching involved in salivary gland morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in branching morphogenesis of a nerve	ISS Inferred from Sequence or Structural Similarity more info
involved_in bud elongation involved in lung branching	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell fate commitment	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to hypoxia	IEA Inferred from Electronic Annotation more info
involved_in cellular response to retinoic acid	IEA Inferred from Electronic Annotation more info
involved_in cellular response to transforming growth factor beta stimulus	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in collagen-activated tyrosine kinase receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in digestive tract development	ISS Inferred from Sequence or Structural Similarity more info
involved_in embryonic cranial skeleton morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic digestive tract morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in embryonic organ development	ISS Inferred from Sequence or Structural Similarity more info
involved_in embryonic organ morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in embryonic pattern specification	ISS Inferred from Sequence or Structural Similarity more info
involved_in endochondral bone growth	IEA Inferred from Electronic Annotation more info
involved_in ephrin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in epidermal growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in epidermis morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in epithelial cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in epithelial cell proliferation involved in salivary gland morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in epithelial to mesenchymal transition	IEA Inferred from Electronic Annotation more info
involved_in fibroblast growth factor receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway	IPI Inferred from Physical Interaction more info	PubMed
involved_in fibroblast growth factor receptor signaling pathway involved in hemopoiesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in fibroblast growth factor receptor signaling pathway involved in mammary gland specification	ISS Inferred from Sequence or Structural Similarity more info
involved_in fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow cell	ISS Inferred from Sequence or Structural Similarity more info
involved_in fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development	ISS Inferred from Sequence or Structural Similarity more info
involved_in fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow	ISS Inferred from Sequence or Structural Similarity more info
involved_in gland morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in hair follicle morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in hepatocyte growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in in utero embryonic development	ISS Inferred from Sequence or Structural Similarity more info
involved_in inner ear morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in insulin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in insulin-like growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in lacrimal gland development	ISS Inferred from Sequence or Structural Similarity more info
involved_in lateral sprouting from an epithelium	ISS Inferred from Sequence or Structural Similarity more info
involved_in limb bud formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in lung alveolus development	ISS Inferred from Sequence or Structural Similarity more info
involved_in lung development	ISS Inferred from Sequence or Structural Similarity more info
involved_in lung lobe morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in lung-associated mesenchyme development	ISS Inferred from Sequence or Structural Similarity more info
involved_in macrophage colony-stimulating factor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in mammary gland bud formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in membranous septum morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in mesenchymal cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in mesenchymal cell differentiation involved in lung development	ISS Inferred from Sequence or Structural Similarity more info
involved_in mesenchymal cell proliferation involved in lung development	ISS Inferred from Sequence or Structural Similarity more info
involved_in mesodermal cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in midbrain development	ISS Inferred from Sequence or Structural Similarity more info
involved_in morphogenesis of embryonic epithelium	ISS Inferred from Sequence or Structural Similarity more info
involved_in multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of keratinocyte proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in odontogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in orbitofrontal cortex development	ISS Inferred from Sequence or Structural Similarity more info
involved_in organ growth	ISS Inferred from Sequence or Structural Similarity more info
involved_in otic vesicle formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in outflow tract septum morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in platelet-derived growth factor receptor-alpha signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in platelet-derived growth factor receptor-beta signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of Wnt signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of canonical Wnt signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cardiac muscle cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell cycle	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell division	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of cell population proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of epithelial cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of epithelial cell proliferation involved in lung morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of mesenchymal cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of phospholipase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of vascular associated smooth muscle cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in post-embryonic development	ISS Inferred from Sequence or Structural Similarity more info
involved_in prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in prostate epithelial cord elongation	ISS Inferred from Sequence or Structural Similarity more info
involved_in prostate gland morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in pyramidal neuron development	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of ERK1 and ERK2 cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of morphogenesis of a branching structure	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of osteoblast differentiation	TAS Traceable Author Statement more info	PubMed
involved_in regulation of osteoblast proliferation	TAS Traceable Author Statement more info	PubMed
involved_in regulation of smooth muscle cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of smoothened signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in reproductive structure development	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to ethanol	IEA Inferred from Electronic Annotation more info
involved_in response to lipopolysaccharide	IEA Inferred from Electronic Annotation more info
involved_in skeletal system morphogenesis	TAS Traceable Author Statement more info	PubMed
involved_in squamous basal epithelial stem cell differentiation involved in prostate gland acinus development	ISS Inferred from Sequence or Structural Similarity more info
involved_in ureteric bud development	ISS Inferred from Sequence or Structural Similarity more info
involved_in vascular endothelial growth factor receptor-1 signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in vascular endothelial growth factor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in ventricular cardiac muscle tissue morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in ventricular zone neuroblast division	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with collagen-containing extracellular matrix	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in excitatory synapse	ISS Inferred from Sequence or Structural Similarity more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in membrane	NAS Non-traceable Author Statement more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: fibroblast growth factor receptor 2

Names: BEK fibroblast growth factor receptor; bacteria-expressed kinase; keratinocyte growth factor receptor; protein tyrosine kinase, receptor like 14

NP_000132.3

EC 2.7.10.1

NP_001138385.1

EC 2.7.10.1

NP_001138386.1

EC 2.7.10.1

NP_001138387.1

EC 2.7.10.1

NP_001138388.1

EC 2.7.10.1

NP_001138389.1

EC 2.7.10.1

NP_001138390.1

EC 2.7.10.1

NP_001138391.1

EC 2.7.10.1

NP_001307583.1

EC 2.7.10.1

NP_001307587.1

EC 2.7.10.1

NP_075259.4

EC 2.7.10.1

NP_075418.1

EC 2.7.10.1

XP_006717771.1

EC 2.7.10.1

XP_006717773.1

EC 2.7.10.1

XP_016871409.1

EC 2.7.10.1

XP_016871410.1

EC 2.7.10.1

XP_016871413.1

EC 2.7.10.1

XP_016871414.1

EC 2.7.10.1

XP_024303655.1

EC 2.7.10.1

XP_024303656.1

EC 2.7.10.1

XP_024303657.1

EC 2.7.10.1

XP_024303658.1

EC 2.7.10.1

XP_024303659.1

EC 2.7.10.1

XP_054221139.1

EC 2.7.10.1

XP_054221140.1

EC 2.7.10.1

XP_054221141.1

EC 2.7.10.1

XP_054221142.1

EC 2.7.10.1

XP_054221143.1

EC 2.7.10.1

XP_054221144.1

EC 2.7.10.1

XP_054221145.1

EC 2.7.10.1

XP_054221146.1

EC 2.7.10.1

XP_054221147.1

EC 2.7.10.1

XP_054221148.1

EC 2.7.10.1

XP_054221149.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_012449.2 RefSeqGene

Range

5001..125129

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_994

mRNA and Protein(s)

NM_000141.5 → NP_000132.3 fibroblast growth factor receptor 2 isoform 1 precursor

See identical proteins and their annotated locations for NP_000132.3

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes isoform 1, also referred to as isoform BEK and K-sam.

Source sequence(s)

BC037338, BC039243, CB305736, CN345547, CX873387, M87770

Consensus CDS

CCDS31298.1

UniProtKB/Swiss-Prot

B4DFC2, E7EVR6, E9PCR0, P18443, P21802, Q01742, Q12922, Q14300, Q14301, Q14302, Q14303, Q14304, Q14305, Q14672, Q14718, Q14719, Q1KHY5, Q86YI4, Q8IXC7, Q96KL9, Q96KM0, Q96KM1, Q96KM2, Q9NZU2, Q9NZU3, Q9UD01, Q9UD02, Q9UIH3, Q9UIH4, Q9UIH5, Q9UIH6, Q9UIH7, Q9UIH8, Q9UM87, Q9UMC6, Q9UNS7, Q9UQH7, Q9UQH8, Q9UQH9, Q9UQI0

UniProtKB/TrEMBL

A0A0A0MR25

Related

ENSP00000351276.6, ENST00000358487.10

Conserved Domains (7) summary

cd04973
Location:47 → 124

Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)

cd05857
Location:164 → 248

Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor

cd05858
Location:271 → 360

Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)

smart00409
Location:174 → 248

IG; Immunoglobulin

smart00410
Location:263 → 359

IG_like; Immunoglobulin like

cd05101
Location:456 → 768

PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2

pfam07714
Location:481 → 757

Pkinase_Tyr; Protein tyrosine kinase
NM_001144913.1 → NP_001138385.1 fibroblast growth factor receptor 2 isoform 3 precursor

See identical proteins and their annotated locations for NP_001138385.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) uses an alternate internal in-frame coding exon (as in variant 2), and an alternate 3' terminal exon, compared to transcript variant 1. This results in an isoform (3) with a different, 1 aa longer protein segment in the mid-region, and a novel shorter C-terminus, compared to isoform 1.

Source sequence(s)

AC009988, AK026508, M97193, U11814, X56191

Consensus CDS

CCDS44489.1

UniProtKB/TrEMBL

A0A5S6RJB7

Related

ENSP00000358052.1, ENST00000369056.5

Conserved Domains (6) summary

cd04973
Location:47 → 124

Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)

cd04974
Location:271 → 358

Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)

cd05857
Location:164 → 248

Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor

smart00410
Location:263 → 357

IG_like; Immunoglobulin like

cd05101
Location:457 → 768

PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2

pfam07714
Location:482 → 758

Pkinase_Tyr; Protein tyrosine kinase
NM_001144914.1 → NP_001138386.1 fibroblast growth factor receptor 2 isoform 4 precursor

See identical proteins and their annotated locations for NP_001138386.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) is missing two consecutive in-frame coding exons compared to transcript variant 1. This results in a shorter isoform (4) lacking an internal protein segment compared to isoform 1.

Source sequence(s)

AB084153, BC037338, CB305736, M97193, U11814

Consensus CDS

CCDS44486.1

UniProtKB/TrEMBL

A0A0A0MR25

Related

ENSP00000358057.4, ENST00000369061.8

Conserved Domains (5) summary

cd04973
Location:47 → 124

Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)

cd05857
Location:164 → 248

Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor

smart00410
Location:47 → 124

IG_like; Immunoglobulin like

cd05101
Location:344 → 656

PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2

pfam07714
Location:369 → 645

Pkinase_Tyr; Protein tyrosine kinase
NM_001144915.2 → NP_001138387.1 fibroblast growth factor receptor 2 isoform 5 precursor

See identical proteins and their annotated locations for NP_001138387.1

Status: REVIEWED

Description

Transcript Variant: This variant (5) uses an alternate 5' terminal non-coding exon, and is missing an internal in-frame coding exon, compared to transcript variant 1. This results in a shorter isoform (5) lacking an internal protein segment compared to isoform 1.

Source sequence(s)

AK294026, BC037338, CB305736, M87770

Consensus CDS

CCDS53584.1

UniProtKB/TrEMBL

A0A141AXF4

Related

ENSP00000350166.5, ENST00000357555.9

Conserved Domains (6) summary

cd05857
Location:75 → 159

Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor

cd05858
Location:182 → 271

Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)

smart00409
Location:85 → 159

IG; Immunoglobulin

smart00410
Location:174 → 270

IG_like; Immunoglobulin like

cd05101
Location:367 → 679

PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2

pfam07714
Location:392 → 668

Pkinase_Tyr; Protein tyrosine kinase
NM_001144916.2 → NP_001138388.1 fibroblast growth factor receptor 2 isoform 6 precursor

See identical proteins and their annotated locations for NP_001138388.1

Status: REVIEWED

Description

Transcript Variant: This variant (6) uses an alternate 5' terminal exon, and is missing two consecutive in-frame coding exons, compared to transcript variant 1. This results in a shorter isoform (6) lacking an internal protein segment compared to isoform 1.

Source sequence(s)

AK308621, BC037338, CB305736, M97193

UniProtKB/TrEMBL

E7EVR7

Conserved Domains (6) summary

cd05857
Location:49 → 133

Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor

cd05858
Location:156 → 245

Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)

smart00409
Location:59 → 133

IG; Immunoglobulin

smart00410
Location:148 → 244

IG_like; Immunoglobulin like

cd05101
Location:341 → 653

PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2

pfam07714
Location:366 → 642

Pkinase_Tyr; Protein tyrosine kinase
NM_001144917.2 → NP_001138389.1 fibroblast growth factor receptor 2 isoform 7 precursor

See identical proteins and their annotated locations for NP_001138389.1

Status: REVIEWED

Description

Transcript Variant: This variant (7) is missing two consecutive in-frame coding exons compared to transcript variant 1. This results in a shorter isoform (7) lacking an internal protein segment compared to isoform 1.

Source sequence(s)

BC037338, BC039243, CB305736, CN345547, M87771, U11814

Consensus CDS

CCDS44487.1

UniProtKB/TrEMBL

A0A0A0MR25

Related

ENSP00000358056.4, ENST00000369060.8

Conserved Domains (6) summary

cd04973
Location:47 → 124

Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)

cd05857
Location:164 → 248

Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor

smart00410
Location:47 → 124

IG_like; Immunoglobulin like

cd05101
Location:340 → 652

PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2

pfam07714
Location:365 → 641

Pkinase_Tyr; Protein tyrosine kinase

cl11960
Location:271 → 363

Ig; Immunoglobulin domain
NM_001144918.2 → NP_001138390.1 fibroblast growth factor receptor 2 isoform 8 precursor

See identical proteins and their annotated locations for NP_001138390.1

Status: REVIEWED

Description

Transcript Variant: This variant (8) is missing two consecutive in-frame coding exons, and uses an alternate in-frame donor splice site at another coding exon, compared to transcript variant 1. This results in a shorter isoform (8) lacking an internal protein segment and additional 2 aa, compared to isoform 1.

Source sequence(s)

BC037338, BC039243, CB305736, CN345547, U11814

Consensus CDS

CCDS44485.1

UniProtKB/TrEMBL

E7EVR7

Related

ENSP00000348559.4, ENST00000356226.8

Conserved Domains (3) summary

cd05857
Location:49 → 133

Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor

cd05858
Location:156 → 245

Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)

cd05101
Location:339 → 651

PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
NM_001144919.2 → NP_001138391.1 fibroblast growth factor receptor 2 isoform 9 precursor

See identical proteins and their annotated locations for NP_001138391.1

Status: REVIEWED

Description

Transcript Variant: This variant (9) is missing an in-frame coding exon, uses an alternate internal in-frame coding exon (as in variant 2) and an alternate 3' terminal exon, compared to transcript variant 1. This results in a shorter isoform (9), which differs in two internal segments, and has a novel C-terminus compared to isoform 1.

Source sequence(s)

AC009988, AK026508, BC039243, CN345547, U11814

Consensus CDS

CCDS44488.1

UniProtKB/TrEMBL

A0A141AXF0, A0A141AXF1

Related

ENSP00000353262.3, ENST00000360144.7

Conserved Domains (6) summary

cd04974
Location:182 → 269

Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)

cd05857
Location:75 → 159

Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor

smart00409
Location:85 → 159

IG; Immunoglobulin

smart00410
Location:174 → 268

IG_like; Immunoglobulin like

cd05101
Location:368 → 679

PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2

pfam07714
Location:393 → 669

Pkinase_Tyr; Protein tyrosine kinase
NM_001320654.2 → NP_001307583.1 fibroblast growth factor receptor 2 isoform 15

Status: REVIEWED

Description

Transcript Variant: This variant (15) represents use of an alternate promoter and therefore differs in the 5' UTR and 5' coding region compared to variant 1. These differences cause translation initiation at a downstream start codon and result in an isoform (15) with a shorter N-terminus compared to isoform 1.

Source sequence(s)

AC009988, BC037338, CB305736, X52832

Consensus CDS

CCDS81514.1

UniProtKB/TrEMBL

A0A141AXF2, S4R381

Related

ENSP00000474011.1, ENST00000478859.5

Conserved Domains (2) summary

cd05858
Location:43 → 132

Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)

cd05101
Location:228 → 540

PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
NM_001320658.2 → NP_001307587.1 fibroblast growth factor receptor 2 isoform 16 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (16) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The encoded isoform (16) is shorter than isoform 1.

Source sequence(s)

BC037338, BC039243, CB305736, CN345547, M97193, U11814

Consensus CDS

CCDS81515.1

UniProtKB/TrEMBL

A0A0A0MR25

Related

ENSP00000309878.10, ENST00000351936.11

Conserved Domains (7) summary

cd04973
Location:47 → 124

Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)

cd05857
Location:164 → 248

Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor

cd05858
Location:271 → 360

Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)

smart00409
Location:174 → 248

IG; Immunoglobulin

smart00410
Location:263 → 359

IG_like; Immunoglobulin like

cd05101
Location:454 → 766

PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2

pfam07714
Location:479 → 755

Pkinase_Tyr; Protein tyrosine kinase
NM_022970.4 → NP_075259.4 fibroblast growth factor receptor 2 isoform 2 precursor

See identical proteins and their annotated locations for NP_075259.4

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate internal in-frame coding exon compared to transcript variant 1, resulting in an isoform (2, also known as isoform K-sam-IIH1, IIIb, and BFR-1) with a different, 1 aa longer protein segment in the mid-region compared to isoform 1.

Source sequence(s)

AC009988

Consensus CDS

CCDS7620.2

UniProtKB/TrEMBL

A0A0A0MR25

Related

ENSP00000410294.2, ENST00000457416.7

Conserved Domains (6) summary

cd04973
Location:47 → 124

Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)

cd04974
Location:271 → 358

Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)

cd05857
Location:164 → 248

Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor

smart00410
Location:263 → 357

IG_like; Immunoglobulin like

cd05101
Location:457 → 769

PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2

pfam07714
Location:482 → 758

Pkinase_Tyr; Protein tyrosine kinase
NM_023029.2 → NP_075418.1 fibroblast growth factor receptor 2 isoform 11 precursor

See identical proteins and their annotated locations for NP_075418.1

Status: REVIEWED

Description

Transcript Variant: This variant (11) lacks an in-frame coding exon in the 5' region, compared to variant 1. This results in a shorter isoform (11) lacking an internal protein segment compared to isoform 1.

Source sequence(s)

AC009988, AK308621, BC039243, CB305736, EF057068

Consensus CDS

CCDS73210.1

UniProtKB/TrEMBL

D2CGD1, E7EVR7

Related

ENST00000682296.1

Conserved Domains (6) summary

cd05857
Location:75 → 159

Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor

cd05858
Location:182 → 271

Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)

smart00409
Location:85 → 159

IG; Immunoglobulin

smart00410
Location:174 → 270

IG_like; Immunoglobulin like

cd05101
Location:367 → 679

PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2

pfam07714
Location:392 → 668

Pkinase_Tyr; Protein tyrosine kinase

RNA

NR_073009.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (14) lacks two consecutive exons in the 5' region and has an additional exon in the center region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AB030073, AC009988, BC039243, BC096749, CB305736, M87771, U11814, X52832

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000010.11 Reference GRCh38.p14 Primary Assembly

Range

121478330..121598458 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017015924.3 → XP_016871413.1 fibroblast growth factor receptor 2 isoform X10

UniProtKB/TrEMBL

E7EVR7
XM_024447891.2 → XP_024303659.1 fibroblast growth factor receptor 2 isoform X9

UniProtKB/TrEMBL

E7EVR7

Related

ENSP00000358055.1, ENST00000369059.5

Conserved Domains (3) summary

cd05857
Location:68 → 152

Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor

cd05101
Location:361 → 673

PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2

cl11960
Location:175 → 262

Ig; Immunoglobulin domain
XM_024447889.2 → XP_024303657.1 fibroblast growth factor receptor 2 isoform X8

UniProtKB/TrEMBL

A0A141AXF3

Related

ENSP00000337665.6, ENST00000336553.10

Conserved Domains (3) summary

cd05857
Location:94 → 178

Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor

cd05858
Location:201 → 290

Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)

cd05101
Location:384 → 696

PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
XM_024447887.2 → XP_024303655.1 fibroblast growth factor receptor 2 isoform X6

UniProtKB/TrEMBL

E7EVR7

Related

ENSP00000484154.1, ENST00000613048.4

Conserved Domains (3) summary

cd05857
Location:94 → 178

Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor

cd05858
Location:201 → 290

Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)

cd05101
Location:386 → 698

PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
XM_024447888.2 → XP_024303656.1 fibroblast growth factor receptor 2 isoform X7

UniProtKB/TrEMBL

E7EVR7

Conserved Domains (3) summary

cd05857
Location:94 → 178

Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor

cd05101
Location:385 → 697

PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2

cl11960
Location:201 → 288

Ig; Immunoglobulin domain
XM_024447890.2 → XP_024303658.1 fibroblast growth factor receptor 2 isoform X5

UniProtKB/TrEMBL

E7EVR7

Conserved Domains (3) summary

cd05857
Location:94 → 178

Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor

cd05101
Location:387 → 699

PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2

cl11960
Location:201 → 288

Ig; Immunoglobulin domain
XM_006717708.4 → XP_006717771.1 fibroblast growth factor receptor 2 isoform X1

UniProtKB/TrEMBL

A0A0A0MR25

Conserved Domains (6) summary

cd04973
Location:66 → 143

Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)

cd04974
Location:290 → 377

Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)

cd05857
Location:183 → 267

Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor

smart00410
Location:282 → 376

IG_like; Immunoglobulin like

cd05101
Location:474 → 786

PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2

pfam07714
Location:499 → 775

Pkinase_Tyr; Protein tyrosine kinase
XM_017015925.3 → XP_016871414.1 fibroblast growth factor receptor 2 isoform X11

UniProtKB/TrEMBL

A0A804HI76

Related

ENSP00000506937.1, ENST00000684153.1
XM_017015921.3 → XP_016871410.1 fibroblast growth factor receptor 2 isoform X4

UniProtKB/TrEMBL

A0A0A0MR25

Conserved Domains (7) summary

cd04973
Location:66 → 143

Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)

cd05857
Location:183 → 267

Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor

cd05858
Location:290 → 379

Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)

smart00409
Location:193 → 267

IG; Immunoglobulin

smart00410
Location:282 → 378

IG_like; Immunoglobulin like

cd05101
Location:473 → 785

PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2

pfam07714
Location:498 → 774

Pkinase_Tyr; Protein tyrosine kinase
XM_017015920.3 → XP_016871409.1 fibroblast growth factor receptor 2 isoform X3

UniProtKB/TrEMBL

A0A5S6RJB7
XM_006717710.5 → XP_006717773.1 fibroblast growth factor receptor 2 isoform X2

UniProtKB/TrEMBL

A0A5S6RJB7

Conserved Domains (6) summary

cd04973
Location:66 → 143

Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)

cd04974
Location:290 → 377

Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)

cd05857
Location:183 → 267

Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor

smart00410
Location:282 → 376

IG_like; Immunoglobulin like

cd05101
Location:476 → 788

PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2

pfam07714
Location:501 → 777

Pkinase_Tyr; Protein tyrosine kinase

Alternate T2T-CHM13v2.0

Genomic

NC_060934.1 Alternate T2T-CHM13v2.0

Range

122374405..122494614 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054365173.1 → XP_054221148.1 fibroblast growth factor receptor 2 isoform X10
XM_054365172.1 → XP_054221147.1 fibroblast growth factor receptor 2 isoform X9
XM_054365171.1 → XP_054221146.1 fibroblast growth factor receptor 2 isoform X8
XM_054365169.1 → XP_054221144.1 fibroblast growth factor receptor 2 isoform X6
XM_054365170.1 → XP_054221145.1 fibroblast growth factor receptor 2 isoform X7
XM_054365168.1 → XP_054221143.1 fibroblast growth factor receptor 2 isoform X5
XM_054365164.1 → XP_054221139.1 fibroblast growth factor receptor 2 isoform X1
XM_054365174.1 → XP_054221149.1 fibroblast growth factor receptor 2 isoform X11
XM_054365167.1 → XP_054221142.1 fibroblast growth factor receptor 2 isoform X4
XM_054365166.1 → XP_054221141.1 fibroblast growth factor receptor 2 isoform X3
XM_054365165.1 → XP_054221140.1 fibroblast growth factor receptor 2 isoform X2

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_022971.1: Suppressed sequence

Description

NM_022971.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
NM_022972.1: Suppressed sequence

Description

NM_022972.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
NM_022973.1: Suppressed sequence

Description

NM_022973.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
NM_022974.1: Suppressed sequence

Description

NM_022974.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
NM_022975.2: Suppressed sequence

Description

NM_022975.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
NM_022976.1: Suppressed sequence

Description

NM_022976.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
NM_023028.1: Suppressed sequence

Description

NM_023028.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
NM_023030.1: Suppressed sequence

Description

NM_023030.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
NM_023031.1: Suppressed sequence

Description

NM_023031.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.