TAX1BP1 Tax1 binding protein 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: TAX1BP1provided by HGNC
Official Full Name: Tax1 binding protein 1provided by HGNC
Primary source: HGNC:HGNC:11575
See related: Ensembl:ENSG00000106052 MIM:605326; AllianceGenome:HGNC:11575
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: T6BP; TXBP151; CALCOCO3
Summary: This gene encodes a HTLV-1 tax1 binding protein. The encoded protein interacts with TNFAIP3, and inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degradation of this protein by caspase-3-like family proteins is associated with apoptosis induced by TNF. This protein may also have a role in the inhibition of inflammatory signaling pathways. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2011]
Expression: Ubiquitous expression in adrenal (RPKM 48.4), thyroid (RPKM 48.2) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 7p15.2

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	7	NC_000007.14 (27739373..27829767)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	7	NC_060931.1 (27875789..27967476)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	7	NC_000007.13 (27778992..27869386)

Chromosome 7 - NC_000007.14 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Decreased TAX1BP1 participates in systemic lupus erythematosus by regulating monocyte/macrophage function.
Title: Decreased TAX1BP1 participates in systemic lupus erythematosus by regulating monocyte/macrophage function.
TNIP1 inhibits selective autophagy via bipartite interaction with LC3/GABARAP and TAX1BP1.
Title: TNIP1 inhibits selective autophagy via bipartite interaction with LC3/GABARAP and TAX1BP1.
Galectin-8 Senses Phagosomal Damage and Recruits Selective Autophagy Adapter TAX1BP1 To Control Mycobacterium tuberculosis Infection in Macrophages.
Title: Galectin-8 Senses Phagosomal Damage and Recruits Selective Autophagy Adapter TAX1BP1 To Control Mycobacterium tuberculosis Infection in Macrophages.
FIP200 controls the TBK1 activation threshold at SQSTM1/p62-positive condensates.
Title: FIP200 controls the TBK1 activation threshold at SQSTM1/p62-positive condensates.
Reconstitution defines the roles of p62, NBR1 and TAX1BP1 in ubiquitin condensate formation and autophagy initiation.
Title: Reconstitution defines the roles of p62, NBR1 and TAX1BP1 in ubiquitin condensate formation and autophagy initiation.
Loss of TAX1BP1-Directed Autophagy Results in Protein Aggregate Accumulation in the Brain.
Title: Loss of TAX1BP1-Directed Autophagy Results in Protein Aggregate Accumulation in the Brain.
evaluated the currently known TBK1-mediated phosphorylation sites in the SKICH domains of NDP52 and TAX1BP1 on the basis of their interactions with NAP1
Title: Mechanistic insights into the interactions of NAP1 with the SKICH domains of NDP52 and TAX1BP1.
Results show that TAX1BP1 translocates to mitochondria in response to RNA virus infection and inducibly interacts with the MAVS adaptor protein and indicate that TAX1BP1 functions as an adaptor molecule for Itch to target MAVS during RNA virus infection and thus restrict virus-induced apoptosis.
Title: TAX1BP1 Restrains Virus-Induced Apoptosis by Facilitating Itch-Mediated Degradation of the Mitochondrial Adaptor MAVS.
TAX1BP1 downregulation by EBV-miR-BART15-3p enhances chemosensitivity of gastric cancer cells to 5-fluorouracil.
Title: TAX1BP1 downregulation by EBV-miR-BART15-3p enhances chemosensitivity of gastric cancer cells to 5-FU.
The induction of antibodies to an AQP4 epitope in mice immunized with the TAX1BP1-derived peptide suggests that a latent HTLV-1 infection could lead to TAX1BP1 antigen presentation and the production of anti-AQP4 antibodies in human neuromyelitis optica.
Title: Immunization of mice with a peptide derived from the HTLV-1 TAX1BP1 protein induces cross-reactive antibodies against aquaporin 4.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association analyses identify variants in developmental genes associated with hypospadias. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SGC31789 (e-PCR)
- UniSTS:2823

D7S2416 (e-PCR), detects polymorphism
- UniSTS:64576

D7S2416 (e-PCR), detects polymorphism
- UniSTS:359

RH65631 (e-PCR)
- UniSTS:64116

WI-11921 (e-PCR)
- UniSTS:57725

SGC32601 (e-PCR)
- UniSTS:62629

TAX1BP1_2449 (e-PCR)
- UniSTS:281039

A007A09 (e-PCR)
- UniSTS:56558

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables kinase binding	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-macromolecule adaptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in autophagy	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of NF-kappaB transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cytoplasmic pattern recognition receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of toll-like receptor 4 signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in protein localization to phagocytic vesicle	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in autophagosome	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in cytosol	TAS Traceable Author Statement more info
located_in extracellular exosome	HDA more info	PubMed
is_active_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in phagophore assembly site	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: tax1-binding protein 1

Names: TRAF6-binding protein; Tax1 (human T-cell leukemia virus type I) binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029523.1 RefSeqGene

Range

5790..95395

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001079864.3 → NP_001073333.1 tax1-binding protein 1 isoform 2

See identical proteins and their annotated locations for NP_001073333.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate in-frame donor splice site at an internal coding exon compared to variant 1. This results in a shorter isoform (2, also known as TXBP151-L) missing an internal protein segment compared to isoform 1. Variants 2 and 3 encode the same isoform.

Source sequence(s)

AF090891, AL136586, BU679319, DC424592

Consensus CDS

CCDS43561.1

UniProtKB/TrEMBL

B4DSG5

Related

ENSP00000265393.6, ENST00000265393.10

Conserved Domains (1) summary

cl25732
Location:17 → 460

SMC_N; RecF/RecN/SMC N terminal domain
NM_001206901.1 → NP_001193830.1 tax1-binding protein 1 isoform 2

See identical proteins and their annotated locations for NP_001193830.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) contains an alternate 5' non-coding exon, and uses an alternate in-frame donor splice site at an internal coding exon compared to variant 1. This results in a shorter isoform (2, also known as TXBP151-L) missing an internal protein segment compared to isoform 1. Variants 2 and 3 encode the same isoform.

Source sequence(s)

AF090891, AK299729, AL136586, BU679319

Consensus CDS

CCDS43561.1

UniProtKB/TrEMBL

B4DSG5

Related

ENSP00000444811.1, ENST00000543117.5

Conserved Domains (1) summary

cl25732
Location:17 → 460

SMC_N; RecF/RecN/SMC N terminal domain
NM_001206902.2 → NP_001193831.1 tax1-binding protein 1 isoform 3

Status: REVIEWED

Description

Transcript Variant: This variant (4) is missing an internal coding exon compared to variant 1. This results in the creation of an upstream ORF (uORF), translation of which will render this transcript a candidate for nonsense-mediated mRNA decay (NMD). However, since the uORF has a weak Kozak signal, translation from an in-frame downstream AUG is possible by leaky scanning, resulting in an isoform (3) with a shorter N-terminus and missing an internal protein segment compared to isoform 1.

Source sequence(s)

AF090891, AL136586, BU679319, DC424592

Consensus CDS

CCDS56471.1

UniProtKB/Swiss-Prot

Q86VP1

Related

ENSP00000391907.2, ENST00000433216.6

Conserved Domains (1) summary

cl23720
Location:14 → 104

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
NM_001362794.2 → NP_001349723.1 tax1-binding protein 1 isoform 4

Status: REVIEWED

Source sequence(s)

AI580161, AI650286, BP208089, BU680065, CA418315, CB138720, DA176922, DB169908, DC357536

UniProtKB/TrEMBL

B4DSG5

Conserved Domains (1) summary

cl25732
Location:17 → 460

SMC_N; RecF/RecN/SMC N terminal domain
NM_001362795.2 → NP_001349724.1 tax1-binding protein 1 isoform 5

Status: REVIEWED

Source sequence(s)

AA100874, AI650286, BP208089, BU680065, CA418315, CB138720, DA176922, DB169908, DC357536

UniProtKB/TrEMBL

B4DSG5

Conserved Domains (1) summary

cl25732
Location:17 → 460

SMC_N; RecF/RecN/SMC N terminal domain
NM_006024.7 → NP_006015.4 tax1-binding protein 1 isoform 1

See identical proteins and their annotated locations for NP_006015.4

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AL136586, BU679319, DC424592

Consensus CDS

CCDS5415.1

UniProtKB/Swiss-Prot

A4D196, B4DKU7, E7ENV2, O60398, O95770, Q13311, Q86VP1, Q9BQG5, Q9UI88

UniProtKB/TrEMBL

B8ZZD4

Related

ENSP00000379612.2, ENST00000396319.7

Conserved Domains (2) summary

pfam07888
Location:17 → 460

CALCOCO1; Calcium binding and coiled-coil domain (CALCOCO1) like

cl23720
Location:131 → 261

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)