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    Nup37 nucleoporin 37 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 299706, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Nup37provided by RGD
    Official Full Name
    nucleoporin 37provided by RGD
    Primary source
    RGD:1307774
    See related
    EnsemblRapid:ENSRNOG00000004727 AllianceGenome:RGD:1307774
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be located in kinetochore; nuclear envelope; and nucleoplasm. Predicted to be part of nuclear pore outer ring. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly. Orthologous to human NUP37 (nucleoporin 37). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 42.9), Spleen (RPKM 35.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nup37 in Genome Data Viewer
    Location:
    7q13
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (24443998..24497088)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (22556544..22609622)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (28715299..28750978)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma, pseudogene 6 Neighboring gene PARP1 binding protein Neighboring gene pro-melanin-concentrating hormone Neighboring gene U6atac minor spliceosomal RNA Neighboring gene uncharacterized LOC120093767 Neighboring gene WASH complex subunit 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Regulation of mRNA trafficking by nuclear pore complexes. Bonnet A, et al. Genes (Basel), 2014 Sep 2. PMID 25184662, Free PMC Article
    2. Cell-cycle-dependent phosphorylation of the nuclear pore Nup107-160 subcomplex. Glavy JS, et al. Proc Natl Acad Sci U S A, 2007 Mar 6. PMID 17360435, Free PMC Article
    3. The entire Nup107-160 complex, including three new members, is targeted as one entity to kinetochores in mitosis. Loïodice I, et al. Mol Biol Cell, 2004 Jul. PMID 15146057, Free PMC Article
    4. Proteomic characterization of the human sperm nucleus. de Mateo S, et al. Proteomics, 2011 Jul. PMID 21630459
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nuclear pore outer ring IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nuclear pore outer ring ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    nucleoporin Nup37

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106775.1 → NP_001100245.1  nucleoporin Nup37

      See identical proteins and their annotated locations for NP_001100245.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473960
      UniProtKB/TrEMBL
      A0A0G2K3M4, A6IFN4
      Conserved Domains (2) summary
      sd00039
      Location:22 → 70
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:64 → 260
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      24443998..24497088
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039078684.2 → XP_038934612.1  nucleoporin Nup37 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K3M4, A6IFN4
      Conserved Domains (2) summary
      sd00039
      Location:22 → 70
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:64 → 260
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. XM_039078685.2 → XP_038934613.1  nucleoporin Nup37 isoform X3

      Conserved Domains (2) summary
      sd00039
      Location:26 → 62
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:2 → 159
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    3. XM_039078686.2 → XP_038934614.1  nucleoporin Nup37 isoform X3

      Conserved Domains (2) summary
      sd00039
      Location:26 → 62
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:2 → 159
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    4. XM_006241198.5 → XP_006241260.1  nucleoporin Nup37 isoform X2

      UniProtKB/TrEMBL
      A0A8I6GDJ4, B1WBY6
      Related
      ENSRNOP00000006760.5, ENSRNOT00000006760.9
      Conserved Domains (3) summary
      COG2319
      Location:57 → 276
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:22 → 70
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:64 → 260
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    5. XM_006241197.4 → XP_006241259.1  nucleoporin Nup37 isoform X1

      See identical proteins and their annotated locations for XP_006241259.1

      UniProtKB/TrEMBL
      A0A0G2K3M4, A6IFN4
      Related
      ENSRNOP00000075343.2, ENSRNOT00000089161.3
      Conserved Domains (2) summary
      sd00039
      Location:22 → 70
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:64 → 260
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RNA

    1. XR_005486570.2 RNA Sequence

      Related
      ENSRNOT00000110049.2
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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