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    Chpt1 choline phosphotransferase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362866, updated on 2-May-2024

    Summary

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    Official Symbol
    Chpt1provided by RGD
    Official Full Name
    choline phosphotransferase 1provided by RGD
    Primary source
    RGD:1359283
    See related
    Ensembl:ENSRNOG00000058271 AllianceGenome:RGD:1359283
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable diacylglycerol cholinephosphotransferase activity. Predicted to be involved in platelet activating factor biosynthetic process. Predicted to act upstream of or within phosphatidylcholine biosynthetic process. Predicted to be located in Golgi membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus and endoplasmic reticulum membrane. Orthologous to human CHPT1 (choline phosphotransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 494.2), Heart (RPKM 384.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Chpt1 in Genome Data Viewer
    Location:
    7q13
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (24753880..24802529, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (22866455..22915111, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (29019518..29070928, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene proline-rich basic protein 1, pseudogene 1 Neighboring gene DNA-damage regulated autophagy modulator 1 Neighboring gene N-acetylglucosamine-1-phosphate transferase subunits alpha and beta Neighboring gene synaptonemal complex protein 3 Neighboring gene uncharacterized LOC102554140 Neighboring gene myosin binding protein C1 Neighboring gene uncharacterized LOC120093549

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Altered mouse cholinephosphotransferase gene expression in kidneys of type 2 diabetic KK/TA mouse. Gohda T, et al. Metabolism, 2004 Jul. PMID 15254874
    2. Cloning, genomic organization, and characterization of a human cholinephosphotransferase. Henneberry AL, et al. J Biol Chem, 2000 Sep 22. PMID 10893425
    3. Cross-talk between remodeling and de novo pathways maintains phospholipid balance through ubiquitination. Butler PL, et al. J Biol Chem, 2010 Feb 26. PMID 20018880, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC95241

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables diacylglycerol cholinephosphotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables diacylglycerol cholinephosphotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables diacylglycerol cholinephosphotransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphotransferase activity, for other substituted phosphate groups IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphotransferase activity, for other substituted phosphate groups ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in CDP-choline pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phosphatidylcholine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphatidylcholine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phospholipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in platelet activating factor biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in platelet activating factor biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cholinephosphotransferase 1
    Names
    cholinephosphotransferase 1 alpha
    diacylglycerol cholinephosphotransferase 1
    NP_001381255.1
    XP_006241292.1
    XP_038935364.1
    XP_038935367.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001394326.1 → NP_001381255.1  cholinephosphotransferase 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/Swiss-Prot
      Q66H21
      Conserved Domains (1) summary
      cl00453
      Location:25 → 337
      CDP-OH_P_transf; CDP-alcohol phosphatidyltransferase

    RNA

    1. NR_172095.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      24753880..24802529 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039079436.2 → XP_038935364.1  cholinephosphotransferase 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZZB6
      Related
      ENSRNOP00000084340.1
      Conserved Domains (1) summary
      cl00453
      Location:25 → 337
      CDP-OH_P_transf; CDP-alcohol phosphatidyltransferase

    2. XM_006241230.4 → XP_006241292.1  cholinephosphotransferase 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6GI18
      Related
      ENSRNOP00000072444.1
      Conserved Domains (1) summary
      cl00453
      Location:25 → 337
      CDP-OH_P_transf; CDP-alcohol phosphatidyltransferase

    3. XM_039079439.2 → XP_038935367.1  cholinephosphotransferase 1 isoform X3

      Conserved Domains (1) summary
      cl00453
      Location:25 → 207
      CDP-OH_P_transf; CDP-alcohol phosphatidyltransferase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q66H21.1 GenPept UniProtKB/Swiss-Prot:Q66H21

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
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