CIN1 Cin1p [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: CIN1
Official Full Name: Cin1p
Primary source: SGD:S000005876
Locus tag: YOR349W
See related: AllianceGenome:SGD:S000005876; FungiDB:YOR349W; VEuPathDB:YOR349W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Predicted to enable GTPase activator activity and beta-tubulin binding activity. Involved in protein folding and tubulin complex assembly. Human ortholog(s) of this gene implicated in early onset progressive encephalopathy with brain atrophy and thin corpus callosum. Orthologous to human TBCD (tubulin folding cofactor D). [provided by Alliance of Genome Resources, Nov 2024]
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Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info
enables beta-tubulin binding	IBA Inferred from Biological aspect of Ancestor more info
enables beta-tubulin binding	IEA Inferred from Electronic Annotation more info
enables beta-tubulin binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in post-chaperonin tubulin folding pathway	IEA Inferred from Electronic Annotation more info
involved_in protein folding	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein folding	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein folding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in tubulin complex assembly	IEA Inferred from Electronic Annotation more info
involved_in tubulin complex assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in tubulin complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info

NP_014994.3

Tubulin folding factor D involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl; CIN1 mRNA level is reduced when downstream gene MNE1 is deleted

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The following sections contain reference sequences that belong to a specific genome build. Explain