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    RPL33A ribosomal 60S subunit protein L33A [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855960, updated on 18-Sep-2024

    Summary

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    Official Symbol
    RPL33A
    Official Full Name
    ribosomal 60S subunit protein L33A
    Primary source
    SGD:S000006064
    Locus tag
    YPL143W
    See related
    AllianceGenome:SGD:S000006064; FungiDB:YPL143W; VEuPathDB:YPL143W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    GCD17; RPL37A
    Summary
    A structural constituent of ribosome. Involved in cytoplasmic translation; rRNA processing; and ribosomal large subunit assembly. Part of cytosolic large ribosomal subunit. Used to study Diamond-Blackfan anemia. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia 5. Orthologous to human RPL35A (ribosomal protein L35a). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See RPL33A in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    2
    Sequence:
    Chromosome: XVI; NC_001148.4 (282122..282970)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Poc4p Neighboring gene ncRNA Neighboring gene protein kinase FRK1 Neighboring gene putative mitogen-activated protein kinase kinase MKK2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Distinct ribosome maturation defects in yeast models of Diamond-Blackfan anemia and Shwachman-Diamond syndrome. Moore JB 4th, et al. Haematologica, 2010 Jan. PMID 19713223, Free PMC Article
    2. Saccharomyces cerevisiae ribosomal protein L37 is encoded by duplicate genes that are differentially expressed. Tornow J, et al. Curr Genet, 1994 Jun. PMID 8082197
    3. Screening a yeast promoter library leads to the isolation of the RP29/L32 and SNR17B/RPL37A divergent promoters and the discovery of a gene encoding ribosomal protein L37. Santangelo GM, et al. Gene, 1991 Aug 30. PMID 1840541
    4. Ribosomal protein L33 is required for ribosome biogenesis, subunit joining, and repression of GCN4 translation. Martín-Marcos P, et al. Mol Cell Biol, 2007 Sep. PMID 17548477, Free PMC Article
    5. A yeast chemical genetics approach identifies the compound 3,4,5-trimethoxybenzyl isothiocyanate as a calcineurin inhibitor. Prescott TA, et al. FEBS Lett, 2014 Jan 31. PMID 24374339

    See all (80) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoplasmic translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytoplasmic translation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in rRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosomal large subunit assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosomal large subunit biogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of cytosolic large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytosolic large ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ribosomal 60S subunit protein L33A
    NP_015182.1
    • Ribosomal 60S subunit protein L33A; N-terminally acetylated; rpl33a null mutant exhibits slow growth while rpl33a rpl33b double null mutant is inviable; homologous to mammalian ribosomal protein L35A, no bacterial homolog; RPL33A has a paralog, RPL33B, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      282122..282970
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183957.1 → NP_015182.1  TPA: ribosomal 60S subunit protein L33A [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015182.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3M6, P05744
      UniProtKB/TrEMBL
      A6ZWB1, C7GJ94, C8ZIN6, G2WP40, N1NVG1
      Conserved Domains (1) summary
      pfam01247
      Location:7 → 100
      Ribosomal_L35Ae; Ribosomal protein L35Ae
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P05744.3

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