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    UFD2 ubiquitin-ubiquitin ligase UFD2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851337, updated on 18-Sep-2024

    Summary

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    Official Symbol
    UFD2
    Official Full Name
    ubiquitin-ubiquitin ligase UFD2
    Primary source
    SGD:S000002349
    Locus tag
    YDL190C
    See related
    AllianceGenome:SGD:S000002349; FungiDB:YDL190C; VEuPathDB:YDL190C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables ubiquitin-ubiquitin ligase activity. Involved in positive regulation of protein ubiquitination; protein K48-linked ubiquitination; and ubiquitin-dependent ERAD pathway. Located in nucleus. Orthologous to human UBE4B (ubiquitination factor E4B). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See UFD2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (118707..121592, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Arf family GTPase ARF1 Neighboring gene ribosomal 60S subunit protein L35A Neighboring gene Rbs1p Neighboring gene phosphoprotein phosphatase 2A catalytic subunit PPH22

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. E4-Ubiquitin ligase Ufd2 stabilizes Yap8 and modulates arsenic stress responses independent of the U-box motif. Ferreira RT, et al. Biol Open, 2015 Aug 14. PMID 26276098, Free PMC Article
    2. The parallel reaction monitoring method contributes to a highly sensitive polyubiquitin chain quantification. Tsuchiya H, et al. Biochem Biophys Res Commun, 2013 Jun 28. PMID 23726910
    3. The Cdc48 ATPase modulates the interaction between two proteolytic factors Ufd2 and Rad23. Baek GH, et al. Proc Natl Acad Sci U S A, 2011 Aug 16. PMID 21807993, Free PMC Article
    4. Ubiquitin chain elongation enzyme Ufd2 regulates a subset of Doa10 substrates. Liu C, et al. J Biol Chem, 2010 Apr 2. PMID 20159987, Free PMC Article
    5. Structure and function of the yeast U-box-containing ubiquitin ligase Ufd2p. Tu D, et al. Proc Natl Acad Sci U S A, 2007 Oct 2. PMID 17890322, Free PMC Article

    See all (73) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. E4 ubiquitin ligase promotes mitofusin turnover and mitochondrial stress response.
      Title: E4 ubiquitin ligase promotes mitofusin turnover and mitochondrial stress response.
    2. Study results suggest that Ufd2p functions by switching ubiquitin chain linkages to allow the degradation of proteins modified with a ubiquitin linkage, which is normally not targeted to the proteasome.
      Title: Ufd2p synthesizes branched ubiquitin chains to promote the degradation of substrates modified with atypical chains.
    3. The action of Cdc48 could free Rad23 from Ufd2 to allow its subsequent association with Rpn1, which in turn may facilitate the orderly transfer of the substrate from the ubiquitylation apparatus to the proteasome.
      Title: The Cdc48 ATPase modulates the interaction between two proteolytic factors Ufd2 and Rad23.
    4. Data present the crystal structures of Ufd2 in complex with the UBL domains of Rad23 and Dsk2.
      Title: The yeast E4 ubiquitin ligase Ufd2 interacts with the ubiquitin-like domains of Rad23 and Dsk2 via a novel and distinct ubiquitin-like binding domain.
    5. can function as a bona fide E3 ubiquitin ligase to promote ubiquitin chain elongation on a substrate
      Title: Structure and function of the yeast U-box-containing ubiquitin ligase Ufd2p.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin-ubiquitin ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-ubiquitin ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin-ubiquitin ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ERAD pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ERAD pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to ethanol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of protein ubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein K48-linked ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ubiquitin ligase complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin-ubiquitin ligase UFD2
    NP_010091.2
    • Conserved ubiquitin (Ub) chain assembly factor (E4); forms branched Ub chains on substrates destined for degradation, catalyzing K48-linked multi-monoubiquitination of K29-linked Ub chains assembled by Ub-ligase Ufd4p; involved in Ub-fusion degradation pathway, OLE membrane fluidity pathway, stress response survival, and ERAD pathway for misfolded proteins where it promotes ubiquitination and transfer of ERAD substrates to Rad23p; U-box family member; homologous to human Ufd2a, Ufd2b

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      118707..121592 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180250.2 → NP_010091.2  TPA: ubiquitin-ubiquitin ligase UFD2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010091.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VRG3, P54860
      UniProtKB/TrEMBL
      B3LH73, C7GX41, G2WBX6, N1P586
      Conserved Domains (1) summary
      COG5113
      Location:1 → 961
      UFD2; Ubiquitin fusion degradation protein 2 [Posttranslational modification, protein turnover, chaperones]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P54860.3

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