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    gag-pol fusion protein [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855433, updated on 2-Nov-2024

    Summary

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    Official Full Name
    gag-pol fusion protein
    Primary source
    SGD:S000007387
    Locus tag
    YNL284C-B
    See related
    AllianceGenome:SGD:S000007387; FungiDB:YNL284C-B; VEuPathDB:YNL284C-B
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable several functions, including DNA polymerase activity; RNA nuclease activity; and peptidase activity. Predicted to be involved in retrotransposition. Located in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (96964..102232, complement)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene U2 snRNP complex subunit CUS2 Neighboring gene tRNA-Gly Neighboring gene gag protein Neighboring gene tRNA-Asn Neighboring gene mitochondrial 54S ribosomal protein YmL10/YmL18

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A nucleocapsid functionality contained within the amino terminus of the Ty1 protease that is distinct and separable from proteolytic activity. Lawler JF Jr, et al. J Virol, 2002 Jan. PMID 11739699, Free PMC Article
    2. Kinetic pathway of pyrophosphorolysis by a retrotransposon reverse transcriptase. Pandey M, et al. PLoS One, 2008 Jan 2. PMID 18167548, Free PMC Article
    3. A Ty1 integrase nuclear localization signal required for retrotransposition. Moore SP, et al. Mol Cell Biol, 1998 Feb. PMID 9448008, Free PMC Article
    4. A Ty1 reverse transcriptase active-site aspartate mutation blocks transposition but not polymerization. Uzun O, et al. J Virol, 2001 Jul. PMID 11413300, Free PMC Article
    5. Invading the yeast nucleus: a nuclear localization signal at the C terminus of Ty1 integrase is required for transposition in vivo. Kenna MA, et al. Mol Cell Biol, 1998 Feb. PMID 9448009, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-directed DNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-directed DNA polymerase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables RNA nuclease activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables RNA-DNA hybrid ribonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA-directed DNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA-directed DNA polymerase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables aspartic-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA integration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in RNA-templated DNA biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retrotransposition ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in transposition IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in viral translational frameshifting IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in retrotransposon nucleocapsid ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    gag-pol fusion protein
    NP_058178.1
    • Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      96964..102232 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184415.2 → NP_058178.1  TPA: gag-pol fusion protein [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_058178.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0Q8, Q12112
      UniProtKB/TrEMBL
      C8Z7F1
      Conserved Domains (5) summary
      cd09272
      Location:1606 → 1742
      RNase_HI_RT_Ty1; Ty1/Copia family of RNase HI in long-term repeat retroelements
      pfam00665
      Location:664 → 782
      rve; Integrase core domain
      pfam01021
      Location:17 → 114
      TYA; TYA transposon protein
      pfam07727
      Location:1265 → 1494
      RVT_2; Reverse transcriptase (RNA-dependent DNA polymerase)
      cl10031
      Location:73 → 177
      DUF1190; Protein of unknown function (DUF1190)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12112.1

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