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    PML39 Pml39p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854864, updated on 28-Oct-2024

    Summary

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    Official Symbol
    PML39
    Official Full Name
    Pml39p
    Primary source
    SGD:S000004575
    Locus tag
    YML107C
    See related
    AllianceGenome:SGD:S000004575; FungiDB:YML107C; VEuPathDB:YML107C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable zinc ion binding activity. Involved in maintenance of RNA location. Located in nuclear membrane. Part of nuclear pore nuclear basket. [provided by Alliance of Genome Resources, Oct 2024]
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    Genomic context

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    See PML39 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (55265..56269, complement)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Zds2p Neighboring gene uncharacterized protein Neighboring gene orotate phosphoribosyltransferase URA5 Neighboring gene RNA-binding signal recognition particle subunit SEC65

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure of the pre-mRNA leakage 39-kDa protein reveals a single domain of integrated zf-C3HC and Rsm1 modules. Hashimoto H, et al. Sci Rep, 2022 Oct 21. PMID 36271106, Free PMC Article
    2. An evolutionarily conserved bimodular domain anchors ZC3HC1 and its yeast homologue Pml39p to the nuclear basket. Gunkel P, et al. Mol Biol Cell, 2023 May 1. PMID 36857168, Free PMC Article
    3. Pml39, a novel protein of the nuclear periphery required for nuclear retention of improper messenger ribonucleoparticles. Palancade B, et al. Mol Biol Cell, 2005 Nov. PMID 16162818, Free PMC Article
    4. Nuclear pore components affect distinct stages of intron-containing gene expression. Bonnet A, et al. Nucleic Acids Res, 2015 Apr 30. PMID 25845599, Free PMC Article
    5. Synthetic lethality of cohesins with PARPs and replication fork mediators. McLellan JL, et al. PLoS Genet, 2012. PMID 22412391, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structure of the pre-mRNA leakage 39-kDa protein reveals a single domain of integrated zf-C3HC and Rsm1 modules.
      Title: Structure of the pre-mRNA leakage 39-kDa protein reveals a single domain of integrated zf-C3HC and Rsm1 modules.
    2. Together, these data indicate that Pml39 is an upstream effector of the Mlps, involved in the retention of improper mRNPs in the nucleus before their export.
      Title: Pml39, a novel protein of the nuclear periphery required for nuclear retention of improper messenger ribonucleoparticles.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mRNA transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in maintenance of RNA location IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of nuclear pore nuclear basket IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Pml39p
    NP_013600.2
    • Protein required for nuclear retention of unspliced pre-mRNAs; required along with Mlp1p and Pml1p; anchored to the nuclear pore complex through an interaction between its bimodular nuclear basket-interaction domain (NuBaID) and Mlp1p and Mlp2p; localizes to the nuclear basket enables linkage between subpopulations of Mlp1p; associates with the subset of nuclear pores farthest from the nucleolus; homologous to human ZC3HC1, a NuBaID containing protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      55265..56269 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182469.1 → NP_013600.2  TPA: Pml39p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013600.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0H7, Q03760
      UniProtKB/TrEMBL
      B3LLF2, G2WJU9
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03760.2

    Gene LinkOut

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