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    ALO1 D-arabinono-1,4-lactone oxidase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854888, updated on 28-Oct-2024

    Summary

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    Official Symbol
    ALO1
    Official Full Name
    D-arabinono-1,4-lactone oxidase
    Primary source
    SGD:S000004551
    Locus tag
    YML086C
    See related
    AllianceGenome:SGD:S000004551; FungiDB:YML086C; VEuPathDB:YML086C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables D-arabinono-1,4-lactone oxidase activity. Involved in cellular response to oxidative stress and dehydro-D-arabinono-1,4-lactone biosynthetic process. Located in mitochondrial outer membrane. [provided by Alliance of Genome Resources, Oct 2024]
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    Genomic context

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    See ALO1 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (95791..97371, complement)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene SCF ubiquitin ligase complex subunit UFO1 Neighboring gene cytochrome-b5 reductase Neighboring gene alpha-tubulin TUB1 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Bacterial production of D-erythroascorbic acid and L-ascorbic acid through functional expression of Saccharomyces cerevisiae D-arabinono-1,4-lactone oxidase in Escherichia coli. Lee BH, et al. Appl Environ Microbiol, 1999 Oct. PMID 10508108, Free PMC Article
    2. Production of L-ascorbic acid by metabolically engineered Saccharomyces cerevisiae and Zygosaccharomyces bailii. Sauer M, et al. Appl Environ Microbiol, 2004 Oct. PMID 15466554, Free PMC Article
    3. Integral membrane proteins in the mitochondrial outer membrane of Saccharomyces cerevisiae. Burri L, et al. FEBS J, 2006 Apr. PMID 16689936
    4. Mutator genes for suppression of gross chromosomal rearrangements identified by a genome-wide screening in Saccharomyces cerevisiae. Smith S, et al. Proc Natl Acad Sci U S A, 2004 Jun 15. PMID 15184655, Free PMC Article
    5. Protein phosphorylation in mitochondria --a study on fermentative and respiratory growth of Saccharomyces cerevisiae. Ohlmeier S, et al. Electrophoresis, 2010 Sep. PMID 20715123

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables D-arabinono-1,4-lactone oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables D-arabinono-1,4-lactone oxidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables D-arabinono-1,4-lactone oxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables FAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on CH-OH group of donors IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dehydro-D-arabinono-1,4-lactone biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial outer membrane HDA PubMed 
    located_in mitochondrial outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    D-arabinono-1,4-lactone oxidase
    NP_013624.1
    • D-Arabinono-1,4-lactone oxidase; catalyzes the final step in biosynthesis of dehydro-D-arabinono-1,4-lactone, which is protective against oxidative stress; null mutant shows improved incorporation efficiency of noncanonical amino acids in place of amber stop codon

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      95791..97371 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182445.1 → NP_013624.1  TPA: D-arabinono-1,4-lactone oxidase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013624.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0J7, O42618, P54783
      UniProtKB/TrEMBL
      A6ZLX9, B3LLH0, B5VP43, C7GW21, C8ZEB8, G2WJW9, N1P0S5
      Conserved Domains (1) summary
      TIGR01678
      Location:9 → 509
      FAD_lactone_ox; sugar 1,4-lactone oxidases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P54783.1

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