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    SEC66 Sec63 complex subunit SEC66 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852469, updated on 28-Oct-2024

    Summary

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    Official Symbol
    SEC66
    Official Full Name
    Sec63 complex subunit SEC66
    Primary source
    SGD:S000000375
    Locus tag
    YBR171W
    See related
    AllianceGenome:SGD:S000000375; FungiDB:YBR171W; VEuPathDB:YBR171W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    HSS1; KAR7; SEC71
    Summary
    Contributes to protein transmembrane transporter activity. Involved in filamentous growth and post-translational protein targeting to membrane, translocation. Located in endoplasmic reticulum membrane. Part of Sec62/Sec63 complex. [provided by Alliance of Genome Resources, Oct 2024]
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    Genomic context

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    See SEC66 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (578364..578984)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene adenyl-nucleotide exchange factor SSE2 Neighboring gene nuclear protein localization protein 4 Neighboring gene Smy2p Neighboring gene Ump1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural and functional characterization of Sec66p, a new subunit of the polypeptide translocation apparatus in the yeast endoplasmic reticulum. Feldheim D, et al. Mol Biol Cell, 1993 Sep. PMID 8257795, Free PMC Article
    2. Nuclear inner membrane fusion facilitated by yeast Jem1p is required for spindle pole body fusion but not for the first mitotic nuclear division during yeast mating. Nishikawa S, et al. Genes Cells, 2008 Nov. PMID 19090812
    3. Nonlethal sec71-1 and sec72-1 mutations eliminate proteins associated with the Sec63p-BiP complex from S. cerevisiae. Fang H, et al. Mol Biol Cell, 1994 Sep. PMID 7841522, Free PMC Article
    4. Sequence and function analysis of a 4.3 kb fragment of Saccharomyces cerevisiae chromosome II including three open reading frames. Schaaff-Gerstenschläger I, et al. Yeast, 1993 Aug. PMID 8212898
    5. Suppression of a sec63 mutation identifies a novel component of the yeast endoplasmic reticulum translocation apparatus. Kurihara T, et al. Mol Biol Cell, 1993 Sep. PMID 8257794, Free PMC Article

    See all (109) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Sec66-mediated regulation of Pom152 plays an nuclear pore complex-independent role in the control of spindle-pole body duplication
      Title: Sec66-Dependent Regulation of Yeast Spindle-Pole Body Duplication Through Pom152.
    2. Sec71p facilitates nuclear outer-membrane fusion.
      Title: Nuclear inner membrane fusion facilitated by yeast Jem1p is required for spindle pole body fusion but not for the first mitotic nuclear division during yeast mating.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to protein transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in filamentous growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in post-translational protein targeting to membrane, translocation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in post-translational protein targeting to membrane, translocation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in post-translational protein targeting to membrane, translocation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in post-translational protein targeting to membrane, translocation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in post-translational protein targeting to membrane, translocation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Sec62/Sec63 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Sec62/Sec63 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of Sec62/Sec63 complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cell periphery HDA PubMed 
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Sec63 complex subunit SEC66
    NP_009730.3
    • Non-essential subunit of Sec63 complex; with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and translocation into the ER; other members are Sec63p, Sec62p, and Sec72p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      578364..578984
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178519.3 → NP_009730.3  TPA: Sec63 complex subunit SEC66 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009730.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQG7, P33754
      UniProtKB/TrEMBL
      A6ZLB4, B3LMY8, C7GUI6, D3UER6, G2W9H4, N1P9J2
      Conserved Domains (1) summary
      pfam09802
      Location:27 → 197
      Sec66; Preprotein translocase subunit Sec66
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P33754.1

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