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    NBP1 Nbp1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851180, updated on 28-Oct-2024

    Summary

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    Official Symbol
    NBP1
    Official Full Name
    Nbp1p
    Primary source
    SGD:S000004449
    Locus tag
    YLR457C
    See related
    AllianceGenome:SGD:S000004449; FungiDB:YLR457C; VEuPathDB:YLR457C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables lipid binding activity. Involved in spindle pole body duplication and spindle pole body localization. Located in central plaque of spindle pole body and nuclear inner membrane. [provided by Alliance of Genome Resources, Oct 2024]
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    Genomic context

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    See NBP1 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (1055812..1056771, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Pdp3p Neighboring gene pyridoxal 5'-phosphate synthase Neighboring gene GPI-anchor transamidase subunit GAB1 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. NBP1 (Nap1 binding protein 1), an essential gene for G2/M transition of Saccharomyces cerevisiae, encodes a protein of distinct sub-nuclear localization. Shimizu Y, et al. Gene, 2000 Apr 4. PMID 10767562
    2. Specific coiled-coil interactions contribute to a global model of the structure of the spindle pole body. Zizlsperger N, et al. J Struct Biol, 2010 May. PMID 20139001
    3. The SUN protein Mps3 controls Ndc1 distribution and function on the nuclear membrane. Chen J, et al. J Cell Biol, 2014 Feb 17. PMID 24515347, Free PMC Article
    4. The Sad1-UNC-84 homology domain in Mps3 interacts with Mps2 to connect the spindle pole body with the nuclear envelope. Jaspersen SL, et al. J Cell Biol, 2006 Aug 28. PMID 16923827, Free PMC Article
    5. The Saccharomyces cerevisiae spindle pole body (SPB) component Nbp1p is required for SPB membrane insertion and interacts with the integral membrane proteins Ndc1p and Mps2p. Araki Y, et al. Mol Biol Cell, 2006 Apr. PMID 16436507, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. "remodels the structure of chromatin"(RSC) complex plays a role in distributing two spindle pole body (SPB) insertion factors, Nbp1 and Ndc1, to the new SPB. Thus, we provide insight into a role for a SWI/SNF family complex in SPB duplication and ploidy maintenance.
      Title: The budding yeast RSC complex maintains ploidy by promoting spindle pole body insertion.
    2. The amphipathic alpha-helix of Nbp1 is important for spindle pole body insertion into the nuclear envelope from within the nucleus.
      Title: Targeting of Nbp1 to the inner nuclear membrane is essential for spindle pole body duplication.
    3. Nbp1p is a spindle pole body (SPB) component that acts in SPB duplication at the point of SPB insertion into the nuclear envelope.
      Title: The Saccharomyces cerevisiae spindle pole body (SPB) component Nbp1p is required for SPB membrane insertion and interacts with the integral membrane proteins Ndc1p and Mps2p.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables lipid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in spindle pole body duplication IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in spindle pole body duplication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spindle pole body duplication IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in spindle pole body localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in central plaque of spindle pole body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear inner membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in nuclear inner membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    located_in spindle pole body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Nbp1p
    NP_013562.3
    • Spindle pole body (SPB) component; required for the insertion of the duplication plaque into the nuclear membrane during SPB duplication; essential for bipolar spindle formation; component of the Mps2p-Bbp1p complex; NBP1 has a paralog, YPR174C, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      1055812..1056771 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182345.3 → NP_013562.3  TPA: Nbp1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013562.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZ91, P52919
      UniProtKB/TrEMBL
      A7A1X8, B3RHW5, C7GUD4, G2WJR8, N1P7I6
      Conserved Domains (1) summary
      pfam08537
      Location:1 → 319
      NBP1; Fungal Nap binding protein NBP1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P52919.1

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