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    PSR1 phosphatase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850650, updated on 28-Oct-2024

    Summary

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    Official Symbol
    PSR1
    Official Full Name
    phosphatase
    Primary source
    SGD:S000003933
    Locus tag
    YLL010C
    See related
    AllianceGenome:SGD:S000003933; FungiDB:YLL010C; VEuPathDB:YLL010C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables phosphoprotein phosphatase activity. Involved in several processes, including cellular response to amino acid starvation; negative regulation of TORC1 signaling; and positive regulation of transcription by RNA polymerase II. Located in plasma membrane. Orthologous to several human genes including CTDSP2 (CTD small phosphatase 2). [provided by Alliance of Genome Resources, Oct 2024]
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    Genomic context

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    See PSR1 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (129330..130613, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene sterol esterase Neighboring gene rRNA-processing protein SOF1 Neighboring gene copper metallochaperone COX17 Neighboring gene putative ATP-dependent RNA helicase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Improved Acetic Acid Resistance in Saccharomyces cerevisiae by Overexpression of the WHI2 Gene Identified through Inverse Metabolic Engineering. Chen Y, et al. Appl Environ Microbiol, 2016 Jan 29. PMID 26826231, Free PMC Article
    2. Yeast Whi2 and Psr1-phosphatase form a complex and regulate STRE-mediated gene expression. Kaida D, et al. Genes Cells, 2002 Jun. PMID 12090248
    3. Psr1p/Psr2p, two plasma membrane phosphatases with an essential DXDX(T/V) motif required for sodium stress response in yeast. Siniossoglou S, et al. J Biol Chem, 2000 Jun 23. PMID 10777497
    4. The Whi2p-Psr1p/Psr2p complex regulates interference competition and expansion of cells with competitive advantage in yeast colonies. Maršíková J, et al. Proc Natl Acad Sci U S A, 2020 Jun 30. PMID 32541056, Free PMC Article
    5. The TORC1 effector kinase Npr1 fine tunes the inherent activity of the Mep2 ammonium transport protein. Boeckstaens M, et al. Nat Commun, 2014. PMID 24476960

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoprotein phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphoprotein phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to amino acid starvation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in cellular response to amino acid starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to heat IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of TORC1 signaling IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of TORC1 signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    phosphatase
    NP_013091.1
    • Plasma membrane-associated protein phosphatase; involved in the general stress response and the inactivating dephosphorylation of Mep2p; required along with binding partner Whi2p for full activation of STRE-mediated gene expression, possibly through Msn2p dephosphorylation, and for inhibition of TORC1 in response to limiting amino acids; regulates the sodium ion stress response with Psr2p; member of the HAD family of protein phosphatases

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      129330..130613 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181830.1 → NP_013091.1  TPA: phosphatase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013091.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VXZ2, Q07800
      UniProtKB/TrEMBL
      A7A0P6, B3LTF7, C8ZCW3
      Conserved Domains (1) summary
      COG5190
      Location:6 → 427
      FCP1; TFIIF-interacting CTD phosphatase, includes NLI-interacting factor [Transcription]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q07800.1

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