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    COP1 coatomer subunit alpha [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851410, updated on 2-Nov-2024

    Summary

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    Official Symbol
    COP1
    Official Full Name
    coatomer subunit alpha
    Primary source
    SGD:S000002304
    Locus tag
    YDL145C
    See related
    AllianceGenome:SGD:S000002304; FungiDB:YDL145C; VEuPathDB:YDL145C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    RET1; SEC33; SOO1
    Summary
    Enables ubiquitin binding activity. Involved in endoplasmic reticulum to Golgi vesicle-mediated transport; intracellular mRNA localization; and retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Part of COPI vesicle coat. Human ortholog(s) of this gene implicated in autoimmune interstitial lung, joint, and kidney disease. Orthologous to human COPA (COPI coat complex subunit alpha). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See COP1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (194571..198176, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene proteasome regulatory particle lid subunit RPN5 Neighboring gene Ldb17p Neighboring gene uncharacterized protein Neighboring gene chaperonin-containing T-complex subunit CCT4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Non-clathrin-coat protein alpha is a conserved subunit of coatomer and in Saccharomyces cerevisiae is essential for growth. Gerich B, et al. Proc Natl Acad Sci U S A, 1995 Apr 11. PMID 7724544, Free PMC Article
    2. A novel RING finger in the C-terminal domain of the coatomer protein α-COP. Kaur G, et al. Biol Direct, 2015 Dec 14. PMID 26666296, Free PMC Article
    3. Identification of a gene, SOO1, which complements osmo-sensitivity and defect in in vitro beta1,3-glucan synthase activity in Saccharomyces cerevisiae. Lee DW, et al. Biochim Biophys Acta, 1999 Jun 8. PMID 10354506
    4. New mutants of Saccharomyces cerevisiae affected in the transport of proteins from the endoplasmic reticulum to the Golgi complex. Wuestehube LJ, et al. Genetics, 1996 Feb. PMID 8852839, Free PMC Article
    5. epsilon-COP is a structural component of coatomer that functions to stabilize alpha-COP. Duden R, et al. EMBO J, 1998 Feb 16. PMID 9463377, Free PMC Article

    See all (126) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results indicate that ubiquitination, a modification well known to target membrane proteins to the lysosome or vacuole for degradation, can also function as recycling signal to sort a SNARE into COPI vesicles in a non-degradative pathway.
      Title: COPI mediates recycling of an exocytic SNARE by recognition of a ubiquitin sorting signal.
    2. These findings suggest that cisternal maturation involves a COPI-dependent pathway that recycles early Golgi proteins, followed by multiple COPI-independent pathways that recycle late Golgi proteins.
      Title: COPI selectively drives maturation of the early Golgi.
    3. analysis of the structure of alpha-COP in complex with epsilon-COP provides insight into the architecture of the COPI vesicular coat
      Title: Crystal structure of alpha-COP in complex with epsilon-COP provides insight into the architecture of the COPI vesicular coat.
    4. COPI in these mutants is released from Golgi membranes by brefeldin A, a drug that binds directly to guanine nucleotide exchange factor for ADP-ribosylation factor ribosylation factors and blocks Arf1 activation
      Title: Mutations in a highly conserved region of the Arf1p activator GEA2 block anterograde Golgi transport but not COPI recruitment to membranes.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intra-Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular mRNA localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of COPI vesicle coat IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of COPI vesicle coat IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of COPI vesicle coat IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of COPI vesicle coat IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in COPI-coated vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    coatomer subunit alpha
    NP_010136.1
    • Alpha subunit of COPI vesicle coatomer complex; complex surrounds transport vesicles in the early secretory pathway

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      194571..198176 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180205.1 → NP_010136.1  TPA: coatomer subunit alpha [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010136.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VRK3, P53622, Q07595
      UniProtKB/TrEMBL
      C7GKZ6
      Conserved Domains (4) summary
      cd00200
      Location:17 → 322
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:59 → 93
      7WD40; WD40 repeat [structural motif]
      pfam04053
      Location:343 → 770
      Coatomer_WDAD; Coatomer WD associated region
      pfam06957
      Location:829 → 1199
      COPI_C; Coatomer (COPI) alpha subunit C-terminus
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53622.2

    Gene LinkOut

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