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    ATP18 F1F0 ATP synthase subunit i [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854893, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ATP18
    Official Full Name
    F1F0 ATP synthase subunit i
    Primary source
    SGD:S000007247
    Locus tag
    YML081C-A
    See related
    AllianceGenome:SGD:S000007247; FungiDB:YML081C-A; VEuPathDB:YML081C-A
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Contributes to proton-transporting ATP synthase activity, rotational mechanism. Involved in ATP synthesis coupled proton transport and mitochondrial proton-transporting ATP synthase complex assembly. Located in mitochondrion. Part of mitochondrial proton-transporting ATP synthase complex, coupling factor F(o). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See ATP18 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (103983..104162, complement)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene putative cystathionine gamma-synthase Neighboring gene Tda9p Neighboring gene tRNA dihydrouridine synthase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. F1F0-ATP synthase complex interactions in vivo can occur in the absence of the dimer specific subunit e. Gavin PD, et al. J Bioenerg Biomembr, 2005 Apr. PMID 15906150
    2. Isolation of supernumerary yeast ATP synthase subunits e and i. Characterization of subunit i and disruption of its structural gene ATP18. Vaillier J, et al. J Biol Chem, 1999 Jan 1. PMID 9867878
    3. Roles of the lipid-binding motifs of Atg18 and Atg21 in the cytoplasm to vacuole targeting pathway and autophagy. Nair U, et al. J Biol Chem, 2010 Apr 9. PMID 20154084, Free PMC Article
    4. The peripheral stalk participates in the yeast ATP synthase dimerization independently of e and g subunits. Fronzes R, et al. Biochemistry, 2006 May 30. PMID 16716082
    5. Stepwise assembly of dimeric F(1)F(o)-ATP synthase in mitochondria involves the small F(o)-subunits k and i. Wagner K, et al. Mol Biol Cell, 2010 May 1. PMID 20219971, Free PMC Article

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that Su k (Atp19) and Su i (Atp18) are involved in the assembly of Su e (Atp21) and Su g (Atp20) F(1)F(o)-ATP synthase dimers and oligomers.
      Title: Stepwise assembly of dimeric F(1)F(o)-ATP synthase in mitochondria involves the small F(o)-subunits k and i.
    2. lipid-binding motifs of Atg18 and Atg21 have roles in the cytoplasm to vacuole targeting pathway and autophagy
      Title: Roles of the lipid-binding motifs of Atg18 and Atg21 in the cytoplasm to vacuole targeting pathway and autophagy.
    3. Membrane complexes form stable associations such that dimers can be retrieved from detergent lysates of mitochondria.
      Title: F1F0-ATP synthase complex interactions in vivo can occur in the absence of the dimer specific subunit e.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables proton transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to proton-transporting ATP synthase activity, rotational mechanism IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to proton-transporting ATP synthase activity, rotational mechanism IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to proton-transporting ATP synthase activity, rotational mechanism IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ATP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial proton-transporting ATP synthase complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein-containing complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proton motive force-driven ATP synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proton motive force-driven ATP synthesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proton motive force-driven ATP synthesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proton motive force-driven ATP synthesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proton-transporting ATP synthase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of proton-transporting ATP synthase complex, coupling factor F(o) IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proton-transporting ATP synthase complex, coupling factor F(o) IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    F1F0 ATP synthase subunit i
    NP_013629.1
    • Subunit of the mitochondrial F1F0 ATP synthase; F1F0 ATP synthase is a large, evolutionarily conserved enzyme complex required for ATP synthesis; termed subunit I or subunit j; does not correspond to known ATP synthase subunits in other organisms

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      103983..104162 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184340.1 → NP_013629.1  TPA: F1F0 ATP synthase subunit i [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013629.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0K1, P81450
      UniProtKB/TrEMBL
      A6ZLY3, B3LLH4, C7GW17, C8ZEC3, G2WJX3, N1NXV6
      Conserved Domains (1) summary
      pfam04911
      Location:4 → 54
      ATP-synt_J; ATP synthase j chain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P81450.1

    Gene LinkOut

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