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    UFO1 SCF ubiquitin ligase complex subunit UFO1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854886, updated on 28-Oct-2024

    Summary

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    Official Symbol
    UFO1
    Official Full Name
    SCF ubiquitin ligase complex subunit UFO1
    Primary source
    SGD:S000004553
    Locus tag
    YML088W
    See related
    AllianceGenome:SGD:S000004553; FungiDB:YML088W; VEuPathDB:YML088W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable protein-macromolecule adaptor activity. Predicted to contribute to ubiquitin-protein transferase activity. Involved in DNA damage response; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; and cellular response to methylmercury. Located in cytoplasm and nucleus. Part of SCF ubiquitin ligase complex. [provided by Alliance of Genome Resources, Oct 2024]
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    Genomic context

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    See UFO1 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (92235..94241)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene ribonuclease P Neighboring gene ncRNA Neighboring gene cytochrome-b5 reductase Neighboring gene D-arabinono-1,4-lactone oxidase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The F-box protein, Ufo1, maintains genome stability by recruiting the yeast mating switch endonuclease, Ho, for rapid proteasome degradation. Kaplun L, et al. Isr Med Assoc J, 2006 Apr. PMID 16671359
    2. Sequestration of highly expressed mRNAs in cytoplasmic granules, P-bodies, and stress granules enhances cell viability. Lavut A, et al. PLoS Genet, 2012. PMID 22383896, Free PMC Article
    3. DNA-damage-inducible 1 protein (Ddi1) contains an uncharacteristic ubiquitin-like domain that binds ubiquitin. Nowicka U, et al. Structure, 2015 Mar 3. PMID 25703377, Free PMC Article
    4. DNA damage response-mediated degradation of Ho endonuclease via the ubiquitin system involves its nuclear export. Kaplun L, et al. J Biol Chem, 2003 Dec 5. PMID 14506225
    5. Unique role for the UbL-UbA protein Ddi1 in turnover of SCFUfo1 complexes. Ivantsiv Y, et al. Mol Cell Biol, 2006 Mar. PMID 16478980, Free PMC Article

    See all (61) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ubiquitin interacting motifs are crucial for Ufo1 ubiquitylation in vivo
      Title: New interacting partners of the F-box protein Ufo1 of yeast.
    2. a role for the protein Ddi1 in the turnover of the F-box protein, Ufo1
      Title: Unique role for the UbL-UbA protein Ddi1 in turnover of SCFUfo1 complexes.
    3. describes a unique E3, the F-box protein, Ufo1, of yeast; Ufo1 recruits the mating switch endonuclease, Ho, to the SCF complex for ubiquitylation
      Title: The F-box protein, Ufo1, maintains genome stability by recruiting the yeast mating switch endonuclease, Ho, for rapid proteasome degradation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables protein-macromolecule adaptor activity ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    contributes_to ubiquitin-protein transferase activity ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA damage response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in cellular response to methylmercury IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SCF ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of SCF ubiquitin ligase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    SCF ubiquitin ligase complex subunit UFO1
    NP_013622.1
    • F-box receptor protein; subunit of the Skp1-Cdc53-F-box receptor (SCF) E3 ubiquitin ligase complex; binds to phosphorylated Ho endonuclease, allowing its ubiquitination by SCF and subsequent degradation

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      92235..94241
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182447.1 → NP_013622.1  TPA: SCF ubiquitin ligase complex subunit UFO1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013622.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0J5, Q04511
      UniProtKB/TrEMBL
      B3LLG8, B5VP41, C7GV73, C8ZEB6, G2WJW7
      Conserved Domains (1) summary
      pfam12937
      Location:8 → 52
      F-box-like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q04511.1

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