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    Epha1 Eph receptor A1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 312279, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Epha1provided by RGD
    Official Full Name
    Eph receptor A1provided by RGD
    Primary source
    RGD:1304680
    See related
    EnsemblRapid:ENSRNOG00000017525 AllianceGenome:RGD:1304680
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable fibronectin binding activity; protein kinase binding activity; and transmembrane-ephrin receptor activity. Involved in positive regulation of angiogenesis. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Orthologous to human EPHA1 (EPH receptor A1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Lung (RPKM 82.2), Liver (RPKM 69.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Epha1 in Genome Data Viewer
    Location:
    4q24
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (72213022..72227543, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (71246409..71260920, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (71749100..71763681, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene chloride voltage-gated channel 1 Neighboring gene uncharacterized LOC120102260 Neighboring gene family with sequence similarity 131, member B Neighboring gene zyxin Neighboring gene uncharacterized LOC120102261 Neighboring gene taste receptor, type 2, member 143 Neighboring gene taste receptor, type 2, member 135

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. EphA1 receptor silencing by small interfering RNA has antiangiogenic and antitumor efficacy in hepatocellular carcinoma. Chen G, et al. Oncol Rep, 2010 Feb. PMID 20043122
    2. Fibronectin type I repeat is a nonactivating ligand for EphA1 and inhibits ATF3-dependent angiogenesis. Masuda J, et al. J Biol Chem, 2008 May 9. PMID 18308734
    3. EphA1 interacts with integrin-linked kinase and regulates cell morphology and motility. Yamazaki T, et al. J Cell Sci, 2009 Jan 15. PMID 19118217
    4. EphA4-mediated Rho activation via Vsm-RhoGEF expressed specifically in vascular smooth muscle cells. Ogita H, et al. Circ Res, 2003 Jul 11. PMID 12775584
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ephrin receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables fibronectin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transmembrane receptor protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane-ephrin receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in activation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in activation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in angiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell surface receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ephrin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in multicellular organism development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptidyl-tyrosine phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell-matrix adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of stress fiber assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of stress fiber assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein autophosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in substrate adhesion-dependent cell spreading ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ephrin type-A receptor 1
    Names
    ephrin receptor EphA1
    NP_001101328.1
    XP_008761105.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107858.1 → NP_001101328.1  ephrin type-A receptor 1 precursor

      See identical proteins and their annotated locations for NP_001101328.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473959
      UniProtKB/TrEMBL
      A0A8I6AH50, A6IF76, D3ZDH4
      Related
      ENSRNOP00000024037.3, ENSRNOT00000024037.6
      Conserved Domains (7) summary
      cd09542
      Location:913 → 975
      SAM_EPH-A1; SAM domain of EPH-A1 subfamily of tyrosine kinase receptors
      smart00454
      Location:912 → 977
      SAM; Sterile alpha motif
      cd10479
      Location:28 → 204
      EphR_LBD_A1; Ligand Binding Domain of Ephrin type-A Receptor 1
      cd00063
      Location:454 → 536
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:335 → 426
      fn3; Fibronectin type III domain
      pfam07714
      Location:625 → 881
      Pkinase_Tyr; Protein tyrosine kinase
      cl21453
      Location:620 → 885
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      72213022..72227543 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008762883.4 → XP_008761105.1  ephrin type-A receptor 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AH50
      Conserved Domains (10) summary
      cd09542
      Location:946 → 1008
      SAM_EPH-A1; SAM domain of EPH-A1 subfamily of tyrosine kinase receptors
      smart00454
      Location:945 → 1010
      SAM; Sterile alpha motif
      cd10479
      Location:28 → 204
      EphR_LBD_A1; Ligand Binding Domain of Ephrin type-A Receptor 1
      cd00063
      Location:454 → 536
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00185
      Location:281 → 312
      TNFRSF; CRD2 [structural motif]
      pfam00041
      Location:335 → 426
      fn3; Fibronectin type III domain
      pfam07714
      Location:625 → 914
      Pkinase_Tyr; Protein tyrosine kinase
      pfam14575
      Location:597 → 620
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
      cl21453
      Location:620 → 918
      PKc_like; Protein Kinases, catalytic domain
      cl22855
      Location:252 → 320
      TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
    Nucleotide Protein Strain
    Heading Accession and Version

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