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    Map3k2 mitogen activated protein kinase kinase kinase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171492, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Map3k2provided by RGD
    Official Full Name
    mitogen activated protein kinase kinase kinase 2provided by RGD
    Primary source
    RGD:620967
    See related
    EnsemblRapid:ENSRNOG00000014089 AllianceGenome:RGD:620967
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Mekk2
    Summary
    Enables MAP kinase kinase kinase activity. Involved in protein phosphorylation. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in cytoplasm. Orthologous to human MAP3K2 (mitogen-activated protein kinase kinase kinase 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 134.6), Thymus (RPKM 114.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Map3k2 in Genome Data Viewer
    Location:
    18p12
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (24081444..24153940)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (23807218..23879722)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (24961250..25025488)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene POTE ankyrin domain family, member F Neighboring gene uncharacterized LOC134482924 Neighboring gene protein C, inactivator of coagulation factors Va and VIIIa Neighboring gene ERCC excision repair 3, TFIIH core complex helicase subunit Neighboring gene bridging integrator 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Extracellular ATP stimulates an inhibitory pathway towards growth factor-induced cRaf-1 and MEKK activation in astrocyte cultures. Lenz G, et al. J Neurochem, 2001 May. PMID 11359865
    2. Upregulation of miR-335 reduces myocardial injury following myocardial infarction via targeting MAP3K2. Wang AD, et al. Eur Rev Med Pharmacol Sci, 2021 Jan. PMID 33506923
    3. Hepatic epidermal growth factor-regulated mitogen-activated protein kinase kinase kinase activity in the rat: lack of identity with known forms of raf and MEKK. Gruppuso PA, et al. FEBS Lett, 2000 Jan 21. PMID 10648842
    4. Regulation of cellular functions by the ERK5 signalling pathway. Wang X, et al. Cell Signal, 2006 Jun. PMID 16376520
    5. MEK5 and ERK5 are localized in the nuclei of resting as well as stimulated cells, while MEKK2 translocates from the cytosol to the nucleus upon stimulation. Raviv Z, et al. J Cell Sci, 2004 Apr 1. PMID 15075238

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Upregulation of miR-335 reduces myocardial injury following myocardial infarction via targeting MAP3K2.
      Title: Upregulation of miR-335 reduces myocardial injury following myocardial infarction via targeting MAP3K2.
    2. Rap1 and MEKK2 are critical upstream signaling molecules mediating BDNF stimulation of ERK5 in central nervous system neurons
      Title: Brain-derived neurotrophic factor activates ERK5 in cortical neurons via a Rap1-MEKK2 signaling cascade.
    3. Unlike ERK5 and MEK5, their upstream activator MEKK2 is localized mainly in the cytosol of resting cells, and translocates into the nucleus upon EGF stimulation
      Title: MEK5 and ERK5 are localized in the nuclei of resting as well as stimulated cells, while MEKK2 translocates from the cytosol to the nucleus upon stimulation.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables MAP kinase kinase kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to mechanical stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mitogen-activated protein kinase kinase kinase 2
    NP_612512.1
    XP_038952487.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_138503.1 → NP_612512.1  mitogen-activated protein kinase kinase kinase 2

      See identical proteins and their annotated locations for NP_612512.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/TrEMBL
      A6J2Q3, F1M9D0
      Related
      ENSRNOP00000057715.2, ENSRNOT00000060996.5
      Conserved Domains (3) summary
      cd06405
      Location:44 → 122
      PB1_Mekk2_3; The PB1 domain is present in the two mitogen-activated protein kinase kinases MEKK2 and MEKK3 which are two members of the signaling kinase cascade involved in angiogenesis and early cardiovascular development. The PB1 domain of MEKK2 (and/or MEKK3) ...
      smart00220
      Location:356 → 616
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06652
      Location:353 → 616
      STKc_MEKK2; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      24081444..24153940
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039096559.2 → XP_038952487.1  mitogen-activated protein kinase kinase kinase 2 isoform X1

      Conserved Domains (1) summary
      cd06652
      Location:155 → 418
      STKc_MEKK2; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 2
    Nucleotide Protein Strain
    Heading Accession and Version

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