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    TYS1 tyrosine--tRNA ligase TYS1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853097, updated on 2-Nov-2024

    Summary

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    Official Symbol
    TYS1
    Official Full Name
    tyrosine--tRNA ligase TYS1
    Primary source
    SGD:S000003417
    Locus tag
    YGR185C
    See related
    AllianceGenome:SGD:S000003417; FungiDB:YGR185C; VEuPathDB:YGR185C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    TTS1
    Summary
    Enables sequence-specific mRNA binding activity and tyrosine-tRNA ligase activity. Involved in tyrosyl-tRNA aminoacylation. Located in cytoplasm and nucleus. Used to study cancer; multisystem proteinopathy; and neuropathy. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease dominant intermediate C. Orthologous to human YARS1 (tyrosyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See TYS1 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (866336..867520, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene ubiquinol--cytochrome-c reductase subunit 9 Neighboring gene E3 ubiquitin-protein ligase UBR1 Neighboring gene transcription factor IIF subunit TFG1 Neighboring gene Hgh1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Tyroslyl-tRNA synthetase from baker's yeast. Rapid isolation by affinity elution, molecular weight of the enzyme, and determination of essential sulfhydryl groups. Faulhammer HG, et al. Eur J Biochem, 1977 May 16. PMID 328277
    2. Twenty-first aminoacyl-tRNA synthetase-suppressor tRNA pairs for possible use in site-specific incorporation of amino acid analogues into proteins in eukaryotes and in eubacteria. Kowal AK, et al. Proc Natl Acad Sci U S A, 2001 Feb 27. PMID 11226228, Free PMC Article
    3. Identity of tRNA for yeast tyrosyl-tRNA synthetase: tyrosylation is more sensitive to identity nucleotides than to structural features. Fechter P, et al. Biochemistry, 2000 Feb 22. PMID 10677221
    4. Crystallization and preliminary X-ray crystallographic analysis of yeast tyrosyl-tRNA synthetase complexed with its cognate tRNA. Kusakabe Y, et al. Protein Pept Lett, 2006. PMID 16712521
    5. Three-dimensional structure of the ternary complex of yeast tyrosyl-tRNA synthetase. Tsunoda M, et al. Nucleic Acids Symp Ser (Oxf), 2004. PMID 17150525

    See all (68) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aminoacyl-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding HDA PubMed 
    enables sequence-specific mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables tyrosine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tyrosine-tRNA ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables tyrosine-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tyrosyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tyrosyl-tRNA aminoacylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in tyrosyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic stress granule HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tyrosine--tRNA ligase TYS1
    NP_011701.3
    • Cytoplasmic tyrosyl-tRNA synthetase; required for cytoplasmic protein synthesis; interacts with positions 34 and 35 of the tRNATyr anticodon; mutations in human ortholog YARS are associated with Charcot-Marie-Tooth (CMT) neuropathies; human ortholog YARS functionally complements the heat sensitivity of a ts allele; protein abundance increases in response to DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      866336..867520 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181314.3 → NP_011701.3  TPA: tyrosine--tRNA ligase TYS1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011701.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUW8, P36421
      UniProtKB/TrEMBL
      A6ZUJ6, B3LI49, C7GVV6, C8Z978, G2WER4, N1P478
      Conserved Domains (1) summary
      TIGR00234
      Location:9 → 344
      tyrS; tyrosyl-tRNA synthetase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P36421.3

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