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    SRP68 signal recognition particle subunit SRP68 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855833, updated on 2-Nov-2024

    Summary

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    Official Symbol
    SRP68
    Official Full Name
    signal recognition particle subunit SRP68
    Primary source
    SGD:S000006164
    Locus tag
    YPL243W
    See related
    AllianceGenome:SGD:S000006164; FungiDB:YPL243W; VEuPathDB:YPL243W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable signal recognition particle binding activity. Involved in SRP-dependent cotranslational protein targeting to membrane. Located in cytoplasm and nuclear periphery. Part of signal recognition particle, endoplasmic reticulum targeting. Human ortholog(s) of this gene implicated in severe congenital neutropenia. Orthologous to human SRP68 (signal recognition particle 68). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See SRP68 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (88517..90316)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene UDP-galactose transporter HUT1 Neighboring gene Iqg1p Neighboring gene GTPase-activating protein CIN2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Elongation arrest is a physiologically important function of signal recognition particle. Mason N, et al. EMBO J, 2000 Aug 1. PMID 10921896, Free PMC Article
    2. Nuclear export of yeast signal recognition particle lacking Srp54p by the Xpo1p/Crm1p NES-dependent pathway. Ciufo LF, et al. Curr Biol, 2000 Oct 19. PMID 11069106
    3. Subunits of the Saccharomyces cerevisiae signal recognition particle required for its functional expression. Brown JD, et al. EMBO J, 1994 Sep 15. PMID 7925282, Free PMC Article
    4. eIF5A has a function in the cotranslational translocation of proteins into the ER. Rossi D, et al. Amino Acids, 2014 Mar. PMID 24306454
    5. The RNA Helicase Ded1 from Yeast Is Associated with the Signal Recognition Particle and Is Regulated by SRP21. Yeter-Alat H, et al. Molecules, 2024 Jun 20. PMID 38931009, Free PMC Article

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 7S RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables endoplasmic reticulum signal peptide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables signal recognition particle binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables signal recognition particle binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in SRP-dependent cotranslational protein targeting to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in SRP-dependent cotranslational protein targeting to membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in SRP-dependent cotranslational protein targeting to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear periphery HDA PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of signal recognition particle, endoplasmic reticulum targeting IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of signal recognition particle, endoplasmic reticulum targeting IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of signal recognition particle, endoplasmic reticulum targeting IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    signal recognition particle subunit SRP68
    NP_015081.1
    • Core component of the signal recognition particle (SRP) complex; SRP complex functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane; relocalizes from cytoplasm to the nuclear periphery upon DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      88517..90316
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184057.1 → NP_015081.1  TPA: signal recognition particle subunit SRP68 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015081.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3C8, P38687
      UniProtKB/TrEMBL
      B3LKI9, B5VSU1, C8ZID6, N1P264
      Conserved Domains (1) summary
      cl22422
      Location:24 → 551
      SRP68-RBD; RNA-binding domain of signal recognition particle subunit 68
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38687.1

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