NEW
Try the new Transcript table
These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
Genomic
-
NG_029532.2 RefSeqGene
- Range
-
5000..819343
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
NM_000845.3 → NP_000836.2 metabotropic glutamate receptor 8 isoform a precursor
See identical proteins and their annotated locations for NP_000836.2
Status: REVIEWED
- Description
- Transcript Variant: This variant (1), as well as variants 4 and 5, encodes isoform a.
- Source sequence(s)
-
AC000099, AC000363, AC000367, AC000369, AC000370, AC002057, AC002083, AC002424, AC002533
- Consensus CDS
-
CCDS5794.1
- UniProtKB/Swiss-Prot
- A4D0Y3, B0FZ74, B0M0L0, O00222, O15493, O95945, O95946, Q3MIV9, Q52M02, Q6J165
- UniProtKB/TrEMBL
-
A8K2D2
- Related
- ENSP00000344173.2, ENST00000339582.7
- Conserved Domains (3) summary
-
- cd15454
Location:582 → 892
- 7tmC_mGluR8; metabotropic glutamate receptor 8 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors
- pfam07562
Location:512 → 562
- NCD3G; Nine Cysteines Domain of family 3 GPCR
- cd06376
Location:40 → 504
- PBP1_mGluR_groupIII; ligand-binding domain of the group III metabotropic glutamate receptor
-
NM_001127323.1 → NP_001120795.1 metabotropic glutamate receptor 8 isoform b precursor
See identical proteins and their annotated locations for NP_001120795.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (2) uses an alternate donor splice site at the penultimate exon compared to transcript variant 1, resulting in an isoform (b) of the same length, but with 16 different amino acids at the C-terminus compared to isoform a. This variant was designated as HmGluR8b by Malherbe et al, 1999 (PMID:10216218). Variants 2 and 6 both encode the same isoform (b).
- Source sequence(s)
-
AJ236921, AK315203, BG202742, BG211606
- Consensus CDS
-
CCDS47696.1
- UniProtKB/TrEMBL
-
A8K2D2
- Related
- ENSP00000351142.3, ENST00000358373.8
- Conserved Domains (3) summary
-
- cd15454
Location:582 → 892
- 7tmC_mGluR8; metabotropic glutamate receptor 8 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors
- pfam07562
Location:512 → 562
- NCD3G; Nine Cysteines Domain of family 3 GPCR
- cd06376
Location:40 → 504
- PBP1_mGluR_groupIII; ligand-binding domain of the group III metabotropic glutamate receptor
-
NM_001371083.1 → NP_001358012.1 metabotropic glutamate receptor 8 isoform a precursor
Status: REVIEWED
- Description
- Transcript Variant: This variant (4), as well as variants 1 and 5, encodes isoform a.
- Source sequence(s)
-
AC000099, AC000363, AC000367, AC000369, AC000370, AC002057, AC002083, AC002424, AC002533, KF458593
- Consensus CDS
-
CCDS5794.1
- UniProtKB/Swiss-Prot
- A4D0Y3, B0FZ74, B0M0L0, O00222, O15493, O95945, O95946, Q3MIV9, Q52M02, Q6J165
- UniProtKB/TrEMBL
-
A8K2D2
- Related
- ENSP00000516625.1, ENST00000706917.1
- Conserved Domains (3) summary
-
- cd15454
Location:582 → 892
- 7tmC_mGluR8; metabotropic glutamate receptor 8 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors
- pfam07562
Location:512 → 562
- NCD3G; Nine Cysteines Domain of family 3 GPCR
- cd06376
Location:40 → 504
- PBP1_mGluR_groupIII; ligand-binding domain of the group III metabotropic glutamate receptor
-
NM_001371084.1 → NP_001358013.1 metabotropic glutamate receptor 8 isoform a precursor
Status: REVIEWED
- Description
- Transcript Variant: This variant (5), as well as variants 1 and 4, encodes isoform a.
- Source sequence(s)
-
AC000099, AC000363, AC000367, AC000369, AC000370, AC002057, AC002083, AC002424, AC002533
- Consensus CDS
-
CCDS5794.1
- UniProtKB/Swiss-Prot
- A4D0Y3, B0FZ74, B0M0L0, O00222, O15493, O95945, O95946, Q3MIV9, Q52M02, Q6J165
- UniProtKB/TrEMBL
-
A8K2D2
- Conserved Domains (3) summary
-
- cd15454
Location:582 → 892
- 7tmC_mGluR8; metabotropic glutamate receptor 8 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors
- pfam07562
Location:512 → 562
- NCD3G; Nine Cysteines Domain of family 3 GPCR
- cd06376
Location:40 → 504
- PBP1_mGluR_groupIII; ligand-binding domain of the group III metabotropic glutamate receptor
-
NM_001371085.1 → NP_001358014.1 metabotropic glutamate receptor 8 isoform b precursor
Status: REVIEWED
- Description
- Transcript Variant: This variant (6), as well as variant 2, encodes isoform b.
- Source sequence(s)
-
AC000099, AC000363, AC000367, AC000369, AC000370, AC002057, AC002083, AC002424, AC002533
- Consensus CDS
-
CCDS47696.1
- UniProtKB/TrEMBL
-
A8K2D2
- Related
- ENSP00000516624.1, ENST00000706916.1
- Conserved Domains (3) summary
-
- cd15454
Location:582 → 892
- 7tmC_mGluR8; metabotropic glutamate receptor 8 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors
- pfam07562
Location:512 → 562
- NCD3G; Nine Cysteines Domain of family 3 GPCR
- cd06376
Location:40 → 504
- PBP1_mGluR_groupIII; ligand-binding domain of the group III metabotropic glutamate receptor
-
NM_001371086.1 → NP_001358015.1 metabotropic glutamate receptor 8 isoform c precursor
Status: REVIEWED
- Description
- Transcript Variant: This variant (7) encodes the longest isoform (c).
- Source sequence(s)
-
AC000099, AC000363, AC000367, AC000369, AC000370, AC002057, AC002083, AC002424, AC002533
- UniProtKB/TrEMBL
- A0A9L9PYG5, A8K2D2
- Related
- ENSP00000516623.1, ENST00000706915.1
-
NM_001371087.1 → NP_001358016.1 metabotropic glutamate receptor 8 isoform d
Status: REVIEWED
- Source sequence(s)
-
AC000363, AC000367, AC000369, AC000370, AC002057, AC002083, AC002424, AC002533
- Conserved Domains (3) summary
-
- cd15454
Location:377 → 687
- 7tmC_mGluR8; metabotropic glutamate receptor 8 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors
- pfam07562
Location:307 → 357
- NCD3G; Nine Cysteines Domain of family 3 GPCR
- cl10011
Location:1 → 299
- Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily
-
NM_001371088.1 → NP_001358017.1 metabotropic glutamate receptor 8 isoform e precursor
Status: REVIEWED
- Source sequence(s)
-
AC000099, AC000363, AC000367, AC002424, AC002497, AC002533
RNA
-
NR_028041.1 RNA Sequence
Status: REVIEWED
- Description
- Transcript Variant: This variant (3) contains an additional exon in the central coding region that results in a frameshift, compared to transcript variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD). This variant was designated as HmGluR8c by Malherbe et al, 1999 (PMID:10216218).
- Source sequence(s)
-
AJ236922, AK315203, BC093725, BG202742, BG211606
- Related
-
ENST00000341617.7
-
NR_163849.1 RNA Sequence
Status: REVIEWED
- Source sequence(s)
-
AC000099, AC000363, AC000367, AC000369, AC000370, AC002057, AC002083, AC002424, AC002533
-
NR_163850.1 RNA Sequence
Status: REVIEWED
- Source sequence(s)
-
AC000363, AC000367, AC000369, AC000370, AC002057, AC002083, AC002424, AC002533
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.
Reference GRCh38.p14 Primary Assembly
Genomic
-
NC_000007.14 Reference GRCh38.p14 Primary Assembly
- Range
-
126438598..127252941 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_047420269.1 → XP_047276225.1 metabotropic glutamate receptor 8 isoform X1
-
XM_047420271.1 → XP_047276227.1 metabotropic glutamate receptor 8 isoform X3
-
XM_017012077.2 → XP_016867566.1 metabotropic glutamate receptor 8 isoform X3
- Conserved Domains (3) summary
-
- cd15454
Location:377 → 687
- 7tmC_mGluR8; metabotropic glutamate receptor 8 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors
- pfam07562
Location:307 → 357
- NCD3G; Nine Cysteines Domain of family 3 GPCR
- cl10011
Location:1 → 299
- Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily
-
XM_047420272.1 → XP_047276228.1 metabotropic glutamate receptor 8 isoform X3
-
XM_017012078.2 → XP_016867567.1 metabotropic glutamate receptor 8 isoform X3
- Conserved Domains (3) summary
-
- cd15454
Location:377 → 687
- 7tmC_mGluR8; metabotropic glutamate receptor 8 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors
- pfam07562
Location:307 → 357
- NCD3G; Nine Cysteines Domain of family 3 GPCR
- cl10011
Location:1 → 299
- Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily
-
XM_047420270.1 → XP_047276226.1 metabotropic glutamate receptor 8 isoform X2
-
XM_017012075.2 → XP_016867564.1 metabotropic glutamate receptor 8 isoform X3
- Conserved Domains (3) summary
-
- cd15454
Location:377 → 687
- 7tmC_mGluR8; metabotropic glutamate receptor 8 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors
- pfam07562
Location:307 → 357
- NCD3G; Nine Cysteines Domain of family 3 GPCR
- cl10011
Location:1 → 299
- Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily
-
XM_017012076.2 → XP_016867565.1 metabotropic glutamate receptor 8 isoform X3
- Conserved Domains (3) summary
-
- cd15454
Location:377 → 687
- 7tmC_mGluR8; metabotropic glutamate receptor 8 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors
- pfam07562
Location:307 → 357
- NCD3G; Nine Cysteines Domain of family 3 GPCR
- cl10011
Location:1 → 299
- Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily
-
XM_047420276.1 → XP_047276232.1 metabotropic glutamate receptor 8 isoform X3
-
XM_017012079.2 → XP_016867568.1 metabotropic glutamate receptor 8 isoform X3
- Conserved Domains (3) summary
-
- cd15454
Location:377 → 687
- 7tmC_mGluR8; metabotropic glutamate receptor 8 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors
- pfam07562
Location:307 → 357
- NCD3G; Nine Cysteines Domain of family 3 GPCR
- cl10011
Location:1 → 299
- Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily
-
XM_047420275.1 → XP_047276231.1 metabotropic glutamate receptor 8 isoform X4
-
XM_047420274.1 → XP_047276230.1 metabotropic glutamate receptor 8 isoform X4
-
XM_047420273.1 → XP_047276229.1 metabotropic glutamate receptor 8 isoform X4
-
XM_047420277.1 → XP_047276233.1 metabotropic glutamate receptor 8 isoform X5
RNA
-
XR_007060010.1 RNA Sequence
Alternate T2T-CHM13v2.0
Genomic
-
NC_060931.1 Alternate T2T-CHM13v2.0
- Range
-
127750296..128564614 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_054358000.1 → XP_054213975.1 metabotropic glutamate receptor 8 isoform X1
-
XM_054358007.1 → XP_054213982.1 metabotropic glutamate receptor 8 isoform X3
-
XM_054358002.1 → XP_054213977.1 metabotropic glutamate receptor 8 isoform X3
-
XM_054358008.1 → XP_054213983.1 metabotropic glutamate receptor 8 isoform X3
-
XM_054358005.1 → XP_054213980.1 metabotropic glutamate receptor 8 isoform X3
-
XM_054358001.1 → XP_054213976.1 metabotropic glutamate receptor 8 isoform X2
-
XM_054358003.1 → XP_054213978.1 metabotropic glutamate receptor 8 isoform X3
-
XM_054358004.1 → XP_054213979.1 metabotropic glutamate receptor 8 isoform X3
-
XM_054358012.1 → XP_054213987.1 metabotropic glutamate receptor 8 isoform X3
-
XM_054358006.1 → XP_054213981.1 metabotropic glutamate receptor 8 isoform X3
-
XM_054358011.1 → XP_054213986.1 metabotropic glutamate receptor 8 isoform X4
-
XM_054358010.1 → XP_054213985.1 metabotropic glutamate receptor 8 isoform X4
-
XM_054358009.1 → XP_054213984.1 metabotropic glutamate receptor 8 isoform X4
-
XM_054358013.1 → XP_054213988.1 metabotropic glutamate receptor 8 isoform X5
RNA
-
XR_008487567.1 RNA Sequence