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    NKTR natural killer cell triggering receptor [ Homo sapiens (human) ]

    Gene ID: 4820, updated on 28-Oct-2024

    Summary

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    Official Symbol
    NKTRprovided by HGNC
    Official Full Name
    natural killer cell triggering receptorprovided by HGNC
    Primary source
    HGNC:HGNC:7833
    See related
    Ensembl:ENSG00000114857 MIM:161565; AllianceGenome:HGNC:7833
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    p104; CypNK
    Summary
    This gene encodes a membrane-anchored protein with a hydrophobic amino terminal domain and a cyclophilin-like PPIase domain. It is present on the surface of natural killer cells and facilitates their binding to targets. Its expression is regulated by IL2 activation of the cells. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in bone marrow (RPKM 22.3), skin (RPKM 14.4) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See NKTR in Genome Data Viewer
    Location:
    3p22.1
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (42600612..42648735)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (42618606..42666734)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (42642178..42690227)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene vasoactive intestinal peptide receptor 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:42574871-42575372 Neighboring gene VIPR1 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:42581415-42581916 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:42581917-42582416 Neighboring gene SEC22 homolog C, vesicle trafficking protein Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:42622926-42623752 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19746 Neighboring gene SS18 like 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14246 Neighboring gene ZBTB47 and NKTR antisense RNA 1 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:42672544-42673392 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:42673393-42674241 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19747 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19748 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:42695163-42695804 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14247 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14248 Neighboring gene Sharpr-MPRA regulatory region 3469 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:42700825-42701735 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:42701736-42702645 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19749 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:42706502-42707002 Neighboring gene uncharacterized LOC124906232 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:42708562-42709098 Neighboring gene zinc finger and BTB domain containing 47 Neighboring gene RNA, 7SL, cytoplasmic 567, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Mechanism of target cell recognition by natural killer cells: characterization of a novel triggering molecule restricted to CD3- large granular lymphocytes. Frey JL, et al. J Exp Med, 1991 Dec 1. PMID 1720812, Free PMC Article
    2. Expression of the NK-TR gene is required for NK-like activity in human T cells. Chambers CA, et al. J Immunol, 1994 Mar 15. PMID 8144875
    3. IL-2 regulates the expression of the NK-TR gene via an alternate RNA splicing mechanism. Rinfret A, et al. Mol Immunol, 1993 Oct. PMID 8413330
    4. A cyclophilin-related protein involved in the function of natural killer cells. Anderson SK, et al. Proc Natl Acad Sci U S A, 1993 Jan 15. PMID 8421688, Free PMC Article
    5. Localization of a novel natural killer triggering receptor locus to human chromosome 3p23-p21 and mouse chromosome 9. Young HA, et al. Genomics, 1993 May. PMID 8314596

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of natural killer-tumor recognition sequence (NKTR) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC90527, DKFZp686F1754, DKFZp686G0426, DKFZp686J06106, DKFZp686N24126

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cyclosporin A binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptidyl-prolyl cis-trans isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptidyl-prolyl cis-trans isomerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein peptidyl-prolyl isomerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    NK-tumor recognition protein
    Names
    NK-TR protein
    PPIase
    natural killer triggering receptor
    natural killer-tumor recognition sequence
    natural-killer cells cyclophilin-related protein
    peptidyl-prolyl cis-trans isomerase NKTR
    rotamase
    NP_001336053.1
    NP_001336054.1
    NP_001336055.1
    NP_005376.2
    XP_006713234.1
    XP_016861963.1
    XP_024309307.1
    XP_047304148.1
    XP_047304149.1
    XP_047304150.1
    XP_047304151.1
    XP_047304152.1
    XP_047304153.1
    XP_054202610.1
    XP_054202611.1
    XP_054202612.1
    XP_054202613.1
    XP_054202614.1
    XP_054202615.1
    XP_054202616.1
    XP_054202617.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001349124.2 → NP_001336053.1  NK-tumor recognition protein isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) encodes the longest isoform (c).
      Source sequence(s)
      AC006059, AC092047
      Conserved Domains (1) summary
      cl00197
      Location:7 → 174
      cyclophilin; cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the ...

    2. NM_001349125.2 → NP_001336054.1  NK-tumor recognition protein isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) contains two alternate exons compared to variant 3. The resulting isoform (d) is shorter at the N-terminus compared to isoform c.
      Source sequence(s)
      AC006059, AC092047
      UniProtKB/TrEMBL
      Q6M1B8

    3. NM_001349126.2 → NP_001336055.1  NK-tumor recognition protein isoform e

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) contains two alternate exons and uses two alternate splice junctions compared to variant 3. The resulting isoform (e) is shorter at the N-terminus and lacks a single internal aa compared to isoform c.
      Source sequence(s)
      AC006059, AC092047
      UniProtKB/TrEMBL
      Q6M1B8

    4. NM_005385.4 → NP_005376.2  NK-tumor recognition protein isoform a

      See identical proteins and their annotated locations for NP_005376.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) uses an alternate in-frame splice junction compared to variant 3. The resulting isoform (a) has the same N- and C-termini but is 1 aa shorter compared to isoform c.
      Source sequence(s)
      AA493639, L04288
      Consensus CDS
      CCDS2702.1
      UniProtKB/Swiss-Prot
      P30414
      Related
      ENSP00000232978.8, ENST00000232978.13
      Conserved Domains (2) summary
      pfam09528
      Location:786 → 1161
      Ehrlichia_rpt; Ehrlichia tandem repeat (Ehrlichia_rpt)
      cl00197
      Location:7 → 174
      cyclophilin; cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      42600612..42648735
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024453539.2 → XP_024309307.1  NK-tumor recognition protein isoform X1

      Conserved Domains (1) summary
      cl00197
      Location:7 → 174
      cyclophilin; cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the ...

    2. XM_006713171.3 → XP_006713234.1  NK-tumor recognition protein isoform X2

      Conserved Domains (1) summary
      cl00197
      Location:7 → 174
      cyclophilin; cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the ...

    3. XM_017006474.3 → XP_016861963.1  NK-tumor recognition protein isoform X3

    4. XM_047448196.1 → XP_047304152.1  NK-tumor recognition protein isoform X6

    5. XM_047448197.1 → XP_047304153.1  NK-tumor recognition protein isoform X7

    6. XM_047448193.1 → XP_047304149.1  NK-tumor recognition protein isoform X4

    7. XM_047448192.1 → XP_047304148.1  NK-tumor recognition protein isoform X4

    8. XM_047448194.1 → XP_047304150.1  NK-tumor recognition protein isoform X4

    9. XM_047448195.1 → XP_047304151.1  NK-tumor recognition protein isoform X5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      42618606..42666734
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054346635.1 → XP_054202610.1  NK-tumor recognition protein isoform X1

    2. XM_054346636.1 → XP_054202611.1  NK-tumor recognition protein isoform X2

    3. XM_054346637.1 → XP_054202612.1  NK-tumor recognition protein isoform X3

    4. XM_054346641.1 → XP_054202616.1  NK-tumor recognition protein isoform X6

    5. XM_054346642.1 → XP_054202617.1  NK-tumor recognition protein isoform X7

    6. XM_054346639.1 → XP_054202614.1  NK-tumor recognition protein isoform X4

    7. XM_054346638.1 → XP_054202613.1  NK-tumor recognition protein isoform X4

    8. XM_054346640.1 → XP_054202615.1  NK-tumor recognition protein isoform X4

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001012651.1: Suppressed sequence

      Description
      NM_001012651.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P30414.2 GenPept UniProtKB/Swiss-Prot:P30414

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