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    ADGRF5 adhesion G protein-coupled receptor F5 [ Homo sapiens (human) ]

    Gene ID: 221395, updated on 28-Oct-2024

    Summary

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    Official Symbol
    ADGRF5provided by HGNC
    Official Full Name
    adhesion G protein-coupled receptor F5provided by HGNC
    Primary source
    HGNC:HGNC:19030
    See related
    Ensembl:ENSG00000069122 MIM:620874; AllianceGenome:HGNC:19030
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GPR116; KPG_001
    Summary
    Predicted to enable G protein-coupled receptor activity. Predicted to be involved in several processes, including adenylate cyclase-activating G protein-coupled receptor signaling pathway; energy reserve metabolic process; and fat cell differentiation. Predicted to act upstream of or within several processes, including glomerular filtration; negative regulation of macrophage activation; and pharyngeal arch artery morphogenesis. Located in cell surface and cytoplasmic vesicle. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Broad expression in lung (RPKM 71.0), fat (RPKM 49.8) and 16 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ADGRF5 in Genome Data Viewer
    Location:
    6p12.3
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (46852522..46954939, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (46689996..46792404, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (46820259..46922676, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 66 Neighboring gene meprin A subunit alpha Neighboring gene NANOG hESC enhancer GRCh37_chr6:46814578-46815142 Neighboring gene uncharacterized LOC124901488 Neighboring gene ADGRF5 antisense RNA 1 Neighboring gene uncharacterized LOC105375080 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr6:46894113-46895312 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:46930563-46931189 Neighboring gene uncharacterized LOC124901489 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:46952137-46952638 Neighboring gene adhesion G protein-coupled receptor F1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The clinical relevance of the adhesion G protein-coupled receptor F5 for human diseases and cancers. Jacenik D, et al. Biochim Biophys Acta Mol Basis Dis, 2023 Jun. PMID 36878303, Free PMC Article
    2. The Expression Pattern of Adhesion G Protein-Coupled Receptor F5 Is Related to Cell Adhesion and Metastatic Pathways in Colorectal Cancer-Comprehensive Study Based on In Silico Analysis. Kang H, et al. Cells, 2022 Dec 1. PMID 36497132, Free PMC Article
    3. GPR116, an adhesion G-protein-coupled receptor, promotes breast cancer metastasis via the Gαq-p63RhoGEF-Rho GTPase pathway. Tang X, et al. Cancer Res, 2013 Oct 15. PMID 24008316
    4. GPR116 alleviates acetaminophen-induced liver injury in mice by inhibiting endoplasmic reticulum stress. Xiang Q, et al. Cell Mol Life Sci, 2024 Jul 13. PMID 39001944, Free PMC Article
    5. High expression of GPR116 indicates poor survival outcome and promotes tumor progression in colorectal carcinoma. Yang L, et al. Oncotarget, 2017 Jul 18. PMID 28624786, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The adhesion-GPCR ADGRF5 fuels breast cancer progression by suppressing the MMP8-mediated antitumorigenic effects.
      Title: The adhesion-GPCR ADGRF5 fuels breast cancer progression by suppressing the MMP8-mediated antitumorigenic effects.
    2. GPR116 alleviates acetaminophen-induced liver injury in mice by inhibiting endoplasmic reticulum stress.
      Title: GPR116 alleviates acetaminophen-induced liver injury in mice by inhibiting endoplasmic reticulum stress.
    3. The clinical relevance of the adhesion G protein-coupled receptor F5 for human diseases and cancers.
      Title: The clinical relevance of the adhesion G protein-coupled receptor F5 for human diseases and cancers.
    4. The Expression Pattern of Adhesion G Protein-Coupled Receptor F5 Is Related to Cell Adhesion and Metastatic Pathways in Colorectal Cancer-Comprehensive Study Based on In Silico Analysis.
      Title: The Expression Pattern of Adhesion G Protein-Coupled Receptor F5 Is Related to Cell Adhesion and Metastatic Pathways in Colorectal Cancer-Comprehensive Study Based on In Silico Analysis.
    5. Recurrent novel THBS1-ADGRF5 gene fusion in a new tumor subtype ""Acral FibroChondroMyxoid Tumors"".
      Title: Recurrent novel THBS1-ADGRF5 gene fusion in a new tumor subtype "Acral FibroChondroMyxoid Tumors".
    6. Orphan GPR116 mediates the insulin sensitizing effects of the hepatokine FNDC4 in adipose tissue.
      Title: Orphan GPR116 mediates the insulin sensitizing effects of the hepatokine FNDC4 in adipose tissue.
    7. Adhesion-GPCR Gpr116 (ADGRF5) expression inhibits renal acid secretion.
      Title: Adhesion-GPCR Gpr116 (ADGRF5) expression inhibits renal acid secretion.
    8. MiR-511-5p functions as a tumor suppressor and a predictive of prognosis in colorectal cancer by directly targeting GPR116.
      Title: MiR-511-5p functions as a tumor suppressor and a predictive of prognosis in colorectal cancer by directly targeting GPR116.
    9. our study demonstrated that GPR116 was significantly upregulated in CRC tissues and could serve as an independent prognostic indicator for patients with CRC.
      Title: High expression of GPR116 indicates poor survival outcome and promotes tumor progression in colorectal carcinoma.
    10. These findings show that GPR116 is crucial for the metastasis of breast cancer and support GPR116 as a potential prognostic marker and drug target against metastatic human breast cancer.
      Title: GPR116, an adhesion G-protein-coupled receptor, promotes breast cancer metastasis via the Gαq-p63RhoGEF-Rho GTPase pathway.
    Submit: New GeneRIF Correction See all GeneRIFs (16)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ90640, KIAA0758, DKFZp564O1923

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in energy reserve metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in erythrocyte development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fat cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glomerular filtration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glucose homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in macrophage activation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of macrophage activation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pharyngeal arch artery morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of phospholipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of lipid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in surfactant homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in apical part of cell IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    adhesion G protein-coupled receptor F5
    Names
    G-protein coupled receptor 116
    Ig-Hepta homolog
    probable G-protein coupled receptor 116

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001098518.2 → NP_001091988.1  adhesion G protein-coupled receptor F5 precursor

      See identical proteins and their annotated locations for NP_001091988.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform.
      Source sequence(s)
      AB018301, AL096772, AY140958, AY498875, DB230925
      Consensus CDS
      CCDS4919.1
      UniProtKB/Swiss-Prot
      O94858, Q5TF06, Q6RGN2, Q86SP0, Q8IZF2, Q9Y3Z2
      UniProtKB/TrEMBL
      A8K0D8
      Related
      ENSP00000283296.7, ENST00000283296.12
      Conserved Domains (6) summary
      smart00408
      Location:285 → 351
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:477 → 562
      IG_like; Immunoglobulin like
      pfam00001
      Location:1030 → 1268
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      pfam01390
      Location:170 → 259
      SEA; SEA domain
      pfam01825
      Location:954 → 996
      GPS; GPCR proteolysis site, GPS, motif
      cl21561
      Location:1011 → 1262
      7tm_4; Olfactory receptor

    2. NM_015234.5 → NP_056049.4  adhesion G protein-coupled receptor F5 precursor

      See identical proteins and their annotated locations for NP_056049.4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same isoform.
      Source sequence(s)
      AL096772, AY140958, AY498875, DA588699
      Consensus CDS
      CCDS4919.1
      UniProtKB/Swiss-Prot
      O94858, Q5TF06, Q6RGN2, Q86SP0, Q8IZF2, Q9Y3Z2
      UniProtKB/TrEMBL
      A8K0D8
      Related
      ENSP00000265417.6, ENST00000265417.7
      Conserved Domains (6) summary
      smart00408
      Location:285 → 351
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:477 → 562
      IG_like; Immunoglobulin like
      pfam00001
      Location:1030 → 1268
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      pfam01390
      Location:170 → 259
      SEA; SEA domain
      pfam01825
      Location:954 → 996
      GPS; GPCR proteolysis site, GPS, motif
      cl21561
      Location:1011 → 1262
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      46852522..46954939 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047418326.1 → XP_047274282.1  adhesion G protein-coupled receptor F5 isoform X5

    2. XM_005248893.4 → XP_005248950.1  adhesion G protein-coupled receptor F5 isoform X1

      See identical proteins and their annotated locations for XP_005248950.1

      UniProtKB/TrEMBL
      A8K0D8
      Conserved Domains (6) summary
      smart00408
      Location:285 → 351
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:517 → 602
      IG_like; Immunoglobulin like
      pfam00001
      Location:1070 → 1308
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      pfam01390
      Location:170 → 259
      SEA; SEA domain
      pfam01825
      Location:994 → 1036
      GPS; GPCR proteolysis site, GPS, motif
      cl21561
      Location:1051 → 1302
      7tm_4; Olfactory receptor

    3. XM_017010422.3 → XP_016865911.1  adhesion G protein-coupled receptor F5 isoform X4

      UniProtKB/TrEMBL
      A8K0D8

    4. XM_005248892.4 → XP_005248949.1  adhesion G protein-coupled receptor F5 isoform X1

      See identical proteins and their annotated locations for XP_005248949.1

      UniProtKB/TrEMBL
      A8K0D8
      Conserved Domains (6) summary
      smart00408
      Location:285 → 351
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:517 → 602
      IG_like; Immunoglobulin like
      pfam00001
      Location:1070 → 1308
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      pfam01390
      Location:170 → 259
      SEA; SEA domain
      pfam01825
      Location:994 → 1036
      GPS; GPCR proteolysis site, GPS, motif
      cl21561
      Location:1051 → 1302
      7tm_4; Olfactory receptor

    5. XM_005248895.5 → XP_005248952.1  adhesion G protein-coupled receptor F5 isoform X3

      UniProtKB/TrEMBL
      A8K0D8
      Conserved Domains (6) summary
      smart00408
      Location:285 → 351
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:517 → 602
      IG_like; Immunoglobulin like
      pfam00001
      Location:1070 → 1308
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      pfam01390
      Location:170 → 259
      SEA; SEA domain
      pfam01825
      Location:994 → 1036
      GPS; GPCR proteolysis site, GPS, motif
      cl21561
      Location:1051 → 1302
      7tm_4; Olfactory receptor

    6. XM_005248894.5 → XP_005248951.1  adhesion G protein-coupled receptor F5 isoform X2

      UniProtKB/TrEMBL
      A8K0D8
      Conserved Domains (6) summary
      smart00408
      Location:285 → 351
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:517 → 602
      IG_like; Immunoglobulin like
      pfam00001
      Location:1070 → 1308
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      pfam01390
      Location:170 → 259
      SEA; SEA domain
      pfam01825
      Location:994 → 1036
      GPS; GPCR proteolysis site, GPS, motif
      cl21561
      Location:1051 → 1302
      7tm_4; Olfactory receptor

    7. XM_047418327.1 → XP_047274283.1  adhesion G protein-coupled receptor F5 isoform X6

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      46689996..46792404 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054354567.1 → XP_054210542.1  adhesion G protein-coupled receptor F5 isoform X5

    2. XM_054354563.1 → XP_054210538.1  adhesion G protein-coupled receptor F5 isoform X1

    3. XM_054354566.1 → XP_054210541.1  adhesion G protein-coupled receptor F5 isoform X4

    4. XM_054354562.1 → XP_054210537.1  adhesion G protein-coupled receptor F5 isoform X1

    5. XM_054354565.1 → XP_054210540.1  adhesion G protein-coupled receptor F5 isoform X3

    6. XM_054354564.1 → XP_054210539.1  adhesion G protein-coupled receptor F5 isoform X2

    7. XM_054354568.1 → XP_054210543.1  adhesion G protein-coupled receptor F5 isoform X6

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IZF2.3 GenPept UniProtKB/Swiss-Prot:Q8IZF2

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