U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    KANK3 KN motif and ankyrin repeat domains 3 [ Homo sapiens (human) ]

    Gene ID: 256949, updated on 28-Oct-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    KANK3provided by HGNC
    Official Full Name
    KN motif and ankyrin repeat domains 3provided by HGNC
    Primary source
    HGNC:HGNC:24796
    See related
    Ensembl:ENSG00000186994 MIM:614611; AllianceGenome:HGNC:24796
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ANKRD47
    Summary
    Predicted to be involved in negative regulation of actin filament polymerization. Predicted to be active in cytoplasm and cytoskeleton. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Broad expression in fat (RPKM 11.4), spleen (RPKM 8.7) and 21 other tissues See more
    Orthologs
    mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See KANK3 in Genome Data Viewer
    Location:
    19p13.2
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (8322584..8343262, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (8309103..8329720, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (8387468..8408146, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:8368800-8369366 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:8372005-8372745 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:8372746-8373485 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:8373541-8374070 Neighboring gene CD320 molecule Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:8376825-8377427 Neighboring gene NADH:ubiquinone oxidoreductase subunit A7 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:8380680-8381486 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:8384379-8385346 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancers GRCh37_chr19:8385347-8386314 and GRCh37_chr19:8386315-8387282 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:8387283-8388248 Neighboring gene ribosomal protein S28 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10016 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10017 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10018 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10019 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:8405154-8405654 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:8407589-8408380 Neighboring gene ribosomal protein L17 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13913 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13914 Neighboring gene angiopoietin like 4

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. KANK3 mediates the p38 MAPK pathway to regulate the proliferation and invasion of lung adenocarcinoma cells. Dai Z, et al. Tissue Cell, 2023 Feb. PMID 36463587
    2. KANK family proteins in cancer. Tadijan A, et al. Int J Biochem Cell Biol, 2021 Feb. PMID 33309958
    3. A novel HIF1AN substrate KANK3 plays a tumor-suppressive role in hepatocellular carcinoma. Kim I, et al. Cell Biol Int, 2018 Mar. PMID 29047187
    4. Kank proteins: structure, functions and diseases. Kakinuma N, et al. Cell Mol Life Sci, 2009 Aug. PMID 19554261, Free PMC Article
    5. Kank proteins: a new family of ankyrin-repeat domain-containing proteins. Zhu Y, et al. Biochim Biophys Acta, 2008 Feb. PMID 17996375

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

    Go to the top of the page Help

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

    Go to the top of the page Help

    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • FLJ46061

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in negative regulation of actin filament polymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    KN motif and ankyrin repeat domain-containing protein 3
    Names
    ankyrin repeat domain 47
    ankyrin repeat domain-containing protein 47
    kidney ankyrin repeat-containing protein 3

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_198471.3 → NP_940873.2  KN motif and ankyrin repeat domain-containing protein 3

      See identical proteins and their annotated locations for NP_940873.2

      Status: VALIDATED

      Source sequence(s)
      BC066124
      Consensus CDS
      CCDS12199.1
      UniProtKB/Swiss-Prot
      Q6NY19, Q6NZI1, Q6ZQR3, Q8IUV2
      UniProtKB/TrEMBL
      B0I1P5
      Related
      ENSP00000328923.2, ENST00000330915.7
      Conserved Domains (5) summary
      PHA03247
      Location:59 → 181
      PHA03247; large tegument protein UL36; Provisional
      COG0666
      Location:617 → 763
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      TIGR03480
      Location:188 → 287
      HpnN; hopanoid biosynthesis associated RND transporter like protein HpnN
      sd00045
      Location:622 → 692
      ANK; ANK repeat [structural motif]
      pfam12075
      Location:33 → 74
      KN_motif; KN motif

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      8322584..8343262 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006722718.5 → XP_006722781.1  KN motif and ankyrin repeat domain-containing protein 3 isoform X2

      See identical proteins and their annotated locations for XP_006722781.1

      UniProtKB/Swiss-Prot
      Q6NY19, Q6NZI1, Q6ZQR3, Q8IUV2
      UniProtKB/TrEMBL
      B0I1P5
      Conserved Domains (5) summary
      PHA03247
      Location:59 → 181
      PHA03247; large tegument protein UL36; Provisional
      COG0666
      Location:617 → 763
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      TIGR03480
      Location:188 → 287
      HpnN; hopanoid biosynthesis associated RND transporter like protein HpnN
      sd00045
      Location:622 → 692
      ANK; ANK repeat [structural motif]
      pfam12075
      Location:33 → 74
      KN_motif; KN motif

    2. XM_011527884.2 → XP_011526186.1  KN motif and ankyrin repeat domain-containing protein 3 isoform X2

      See identical proteins and their annotated locations for XP_011526186.1

      UniProtKB/Swiss-Prot
      Q6NY19, Q6NZI1, Q6ZQR3, Q8IUV2
      UniProtKB/TrEMBL
      B0I1P5
      Conserved Domains (5) summary
      PHA03247
      Location:59 → 181
      PHA03247; large tegument protein UL36; Provisional
      COG0666
      Location:617 → 763
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      TIGR03480
      Location:188 → 287
      HpnN; hopanoid biosynthesis associated RND transporter like protein HpnN
      sd00045
      Location:622 → 692
      ANK; ANK repeat [structural motif]
      pfam12075
      Location:33 → 74
      KN_motif; KN motif

    3. XM_017026563.3 → XP_016882052.1  KN motif and ankyrin repeat domain-containing protein 3 isoform X1

      UniProtKB/TrEMBL
      B0I1P5

    RNA

    1. XR_007066726.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      8309103..8329720 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054320456.1 → XP_054176431.1  KN motif and ankyrin repeat domain-containing protein 3 isoform X2

    2. XM_054320455.1 → XP_054176430.1  KN motif and ankyrin repeat domain-containing protein 3 isoform X2

    3. XM_054320454.1 → XP_054176429.1  KN motif and ankyrin repeat domain-containing protein 3 isoform X1

    RNA

    1. XR_008485131.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6NY19.2 GenPept UniProtKB/Swiss-Prot:Q6NY19

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools