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    4930550C14Rik RIKEN cDNA 4930550C14 gene [ Mus musculus (house mouse) ]

    Gene ID: 75311, updated on 2-Nov-2024

    Summary

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    Official Symbol
    4930550C14Rikprovided by MGI
    Official Full Name
    RIKEN cDNA 4930550C14 geneprovided by MGI
    Primary source
    MGI:MGI:1922561
    See related
    Ensembl:ENSMUSG00000005131 AllianceGenome:MGI:1922561
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mfi
    Summary
    Involved in negative regulation of mitochondrial fission and negative regulation of protein targeting to mitochondrion. Located in cytosol and mitochondrial outer membrane. Orthologous to human C11orf65 (chromosome 11 open reading frame 65). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis adult (RPKM 2.2), whole brain E14.5 (RPKM 0.2) and 3 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See 4930550C14Rik in Genome Data Viewer
    Location:
    9 A5.3; 9 29.12 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (53313814..53345726)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (53402713..53434426)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene exophilin 5 Neighboring gene STARR-seq mESC enhancer starr_24141 Neighboring gene protein O-glucosyltransferase 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:53213128-53213311 Neighboring gene microRNA 130c Neighboring gene ataxia telangiectasia mutated Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:53344652-53344897 Neighboring gene nuclear protein in the AT region Neighboring gene STARR-seq mESC enhancer starr_24146

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A Genetic Interaction Map of Insulin Production Identifies Mfi as an Inhibitor of Mitochondrial Fission. Lee J, et al. Endocrinology, 2018 Sep 1. PMID 30059978, Free PMC Article
    2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    3. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    4. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
    5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of mitochondrial fission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of protein targeting to mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein MFI
    Names
    mitochondrial fission factor interactor
    protein C11orf65 homolog
    uncharacterized protein C11orf65 homolog

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001376943.1 → NP_001363872.1  protein MFI isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: Variants 1, 2 and 3 encode the same isoform (1).
      Source sequence(s)
      AC079869
      UniProtKB/Swiss-Prot
      Q3U5F8, Q9D4W2
      Conserved Domains (1) summary
      cd21090
      Location:9 → 263
      C11orf65; chromosome 11 open reading frame 65 and homologs

    2. NM_001376944.1 → NP_001363873.1  protein MFI isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: Variants 1, 2 and 3 encode the same isoform (1).
      Source sequence(s)
      AC079869
      UniProtKB/Swiss-Prot
      Q3U5F8, Q9D4W2
      Conserved Domains (1) summary
      cd21090
      Location:9 → 263
      C11orf65; chromosome 11 open reading frame 65 and homologs

    3. NM_001376945.1 → NP_001363874.1  protein MFI isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC079869, AK153618
      UniProtKB/TrEMBL
      Q14BS3
      Related
      ENSMUSP00000150018.2, ENSMUST00000215668.2

    4. NM_029247.4 → NP_083523.1  protein MFI isoform 1

      See identical proteins and their annotated locations for NP_083523.1

      Status: VALIDATED

      Description
      Transcript Variant: Variants 1, 2 and 3 encode the same isoform (1).
      Source sequence(s)
      AC079869, AK016083, AK153618
      Consensus CDS
      CCDS23183.1
      UniProtKB/Swiss-Prot
      Q3U5F8, Q9D4W2
      Related
      ENSMUSP00000005262.2, ENSMUST00000005262.2
      Conserved Domains (1) summary
      cd21090
      Location:9 → 263
      C11orf65; chromosome 11 open reading frame 65 and homologs

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      53313814..53345726
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036155365.1 → XP_036011258.1  protein MFI isoform X2

      Conserved Domains (1) summary
      cd21090
      Location:9 → 232
      C11orf65; chromosome 11 open reading frame 65 and homologs

    2. XM_006510654.5 → XP_006510717.1  protein MFI isoform X1

      See identical proteins and their annotated locations for XP_006510717.1

      UniProtKB/Swiss-Prot
      Q3U5F8, Q9D4W2
      Conserved Domains (1) summary
      cd21090
      Location:9 → 263
      C11orf65; chromosome 11 open reading frame 65 and homologs

    3. XM_036155364.1 → XP_036011257.1  protein MFI isoform X1

      UniProtKB/Swiss-Prot
      Q3U5F8, Q9D4W2
      Conserved Domains (1) summary
      cd21090
      Location:9 → 263
      C11orf65; chromosome 11 open reading frame 65 and homologs

    4. XM_006510656.5 → XP_006510719.1  protein MFI isoform X2

      Conserved Domains (1) summary
      cd21090
      Location:9 → 232
      C11orf65; chromosome 11 open reading frame 65 and homologs

    5. XM_006510660.5 → XP_006510723.1  protein MFI isoform X3

      See identical proteins and their annotated locations for XP_006510723.1

      UniProtKB/TrEMBL
      Q14BS3
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D4W2.1 GenPept UniProtKB/Swiss-Prot:Q9D4W2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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