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    Pde6h phosphodiesterase 6H [ Rattus norvegicus (Norway rat) ]

    Gene ID: 114248, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Pde6hprovided by RGD
    Official Full Name
    phosphodiesterase 6Hprovided by RGD
    Primary source
    RGD:70933
    See related
    EnsemblRapid:ENSRNOG00000005947 AllianceGenome:RGD:70933
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Pde6g
    Summary
    Predicted to enable cGMP binding activity; calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity; and calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity. Predicted to be involved in positive regulation of G protein-coupled receptor signaling pathway and positive regulation of epidermal growth factor receptor signaling pathway. Predicted to act upstream of or within positive regulation of MAPK cascade. Predicted to be active in photoreceptor outer segment membrane. Human ortholog(s) of this gene implicated in retinal cone dystrophy 3A. Orthologous to human PDE6H (phosphodiesterase 6H). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 84.8), Thymus (RPKM 18.9) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pde6h in Genome Data Viewer
    Location:
    4q43
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (171588896..171604142)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (169857793..169872969)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (170947723..170963046)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene Rho GDP dissociation inhibitor beta Neighboring gene uncharacterized LOC134486856 Neighboring gene uncharacterized LOC134486651 Neighboring gene small nucleolar RNA SNORA62/SNORA6 family

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. PDE6 is an effector for the Wnt/Ca2+/cGMP-signalling pathway in development. Wang H, et al. Biochem Soc Trans, 2004 Nov. PMID 15494017
    2. The identification of the inhibitory gamma-subunits of the type 6 retinal cyclic guanosine monophosphate phosphodiesterase in non-retinal tissues: differential processing of mRNA transcripts. Tate RJ, et al. Genomics, 2002 Apr. PMID 11944991
    3. Characteristics of photoreceptor PDE (PDE6): similarities and differences to PDE5. Cote RH. Int J Impot Res, 2004 Jun. PMID 15224133
    4. The inhibitory gamma subunit of the type 6 retinal cyclic guanosine monophosphate phosphodiesterase is a novel intermediate regulating p42/p44 mitogen-activated protein kinase signaling in human embryonic kidney 293 cells. Wan KF, et al. J Biol Chem, 2001 Oct 12. PMID 11502744
    5. A proline-rich domain in the gamma subunit of phosphodiesterase 6 mediates interaction with SH3-containing proteins. Morin F, et al. Mol Vis, 2003 Sep 18. PMID 14502124

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PDE6 is an effector for the Wnt/Ca2+/cGMP-signalling pathway in development [review]
      Title: PDE6 is an effector for the Wnt/Ca2+/cGMP-signalling pathway in development.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 3',5'-cyclic-nucleotide phosphodiesterase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cGMP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in positive regulation of G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of epidermal growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of epidermal growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in visual perception IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in photoreceptor outer segment membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
    Names
    GMP-PDE gamma
    phosphodiesterase 6G, cGMP-specific, rod, gamma
    phosphodiesterase 6H, cGMP-specific, cone, gamma
    NP_446140.1
    XP_006237620.1
    XP_063141462.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053688.2 → NP_446140.1  retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma

      See identical proteins and their annotated locations for NP_446140.1

      Status: VALIDATED

      Source sequence(s)
      AF169390, AI070066
      UniProtKB/Swiss-Prot
      P61250
      UniProtKB/TrEMBL
      A6IMK0
      Related
      ENSRNOP00000007905.2, ENSRNOT00000007905.5
      Conserved Domains (1) summary
      pfam04868
      Location:2 → 83
      PDE6_gamma; Retinal cGMP phosphodiesterase, gamma subunit

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      171588896..171604142
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006237558.5 → XP_006237620.1  retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma isoform X1

      See identical proteins and their annotated locations for XP_006237620.1

      UniProtKB/Swiss-Prot
      P61250
      UniProtKB/TrEMBL
      A6IMK0
      Conserved Domains (1) summary
      pfam04868
      Location:2 → 83
      PDE6_gamma; Retinal cGMP phosphodiesterase, gamma subunit

    2. XM_063285392.1 → XP_063141462.1  retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma isoform X1

      UniProtKB/Swiss-Prot
      P61250
      UniProtKB/TrEMBL
      A6IMK0
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P61250.1 GenPept UniProtKB/Swiss-Prot:P61250

    Gene LinkOut

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