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    Tmem41b transmembrane protein 41B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361626, updated on 28-Oct-2024

    Summary

    Official Symbol
    Tmem41bprovided by RGD
    Official Full Name
    transmembrane protein 41Bprovided by RGD
    Primary source
    RGD:1310870
    See related
    EnsemblRapid:ENSRNOG00000010752 AllianceGenome:RGD:1310870
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1310870
    Summary
    Predicted to enable phospholipid scramblase activity. Predicted to be involved in autophagosome assembly and intracellular lipid transport. Predicted to be located in mitochondria-associated endoplasmic reticulum membrane contact site. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human TMEM41B (transmembrane protein 41B). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in Brain (RPKM 209.5), Liver (RPKM 206.5) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Tmem41b in Genome Data Viewer
    Location:
    1q33
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (173447362..173461760, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (164012585..164026967, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (174605833..174620192, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene signal peptide, CUB domain and EGF like domain containing 2 Neighboring gene transfer RNA serine (anticodon AGA) 46 Neighboring gene DENN domain containing 5A Neighboring gene U2 spliceosomal RNA Neighboring gene NHP2 ribonucleoprotein, pseudogene 5 Neighboring gene importin 7 Neighboring gene small nucleolar RNA, H/ACA box 23

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Clone Names

    • MGC108971

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables phospholipid scramblase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables phospholipid scramblase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in autophagosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in autophagosome assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in autophagosome assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in intracellular lipid transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lipid transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in modulation by host of viral RNA genome replication IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in plasma membrane phospholipid scrambling IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondria-associated endoplasmic reticulum membrane contact site ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondria-associated endoplasmic reticulum membrane contact site ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    transmembrane protein 41B
    Names
    protein stasimon

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012358.1NP_001012358.1  transmembrane protein 41B

      See identical proteins and their annotated locations for NP_001012358.1

      Status: PROVISIONAL

      Source sequence(s)
      BC089866
      UniProtKB/Swiss-Prot
      Q5FVN2
      UniProtKB/TrEMBL
      A0A8I5ZMA9, A6I7Z8
      Related
      ENSRNOP00000016224.4, ENSRNOT00000016224.7
      Conserved Domains (1) summary
      pfam09335
      Location:129248
      SNARE_assoc; SNARE associated Golgi protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      173447362..173461760 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063267421.1XP_063123491.1  transmembrane protein 41B isoform X1

    2. XM_063267422.1XP_063123492.1  transmembrane protein 41B isoform X2