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    HECW2 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 [ Homo sapiens (human) ]

    Gene ID: 57520, updated on 28-Oct-2024

    Summary

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    Official Symbol
    HECW2provided by HGNC
    Official Full Name
    HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2provided by HGNC
    Primary source
    HGNC:HGNC:29853
    See related
    Ensembl:ENSG00000138411 MIM:617245; AllianceGenome:HGNC:29853
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NEDL2; NDHSAL
    Summary
    This gene encodes a member of a family of E3 ubiquitin ligases which plays an important role in the proliferation, migration and differentiation of neural crest cells as a regulator of glial cell line-derived neurotrophic factor (GDNF)/Ret signaling. This gene also plays an important role in angiogenesis through stabilization of endothelial cell-to-cell junctions as a regulator of angiomotin-like 1 stability. The encoded protein contains an N-terminal calcium/lipid-binding (C2) domain involved in membrane targeting, two-four WW domains responsible for cellular localization and substrate recognition, and a C-terminal homologous with E6-associated protein C-terminus (HECT) catalytic domain. Naturally occurring mutations in this gene are associated with neurodevelopmental delay, hypotonia, and epilepsy. The decreased expression of this gene in the aganglionic colon is associated with Hirschsprung's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]
    Expression
    Broad expression in spleen (RPKM 4.0), placenta (RPKM 3.5) and 19 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See HECW2 in Genome Data Viewer
    Location:
    2q32.3
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (196194072..196593554, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (196678133..197077648, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (197058796..197458278, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene dynein axonemal heavy chain 7 Neighboring gene glutathione S-transferase alpha 5 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16890 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16891 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16892 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:196961660-196962248 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16893 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16894 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16895 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:196977894-196978422 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:197023734-197024234 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16896 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12202 Neighboring gene uncharacterized LOC101927454 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12203 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16897 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16898 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16899 Neighboring gene small nucleolar RNA U13 Neighboring gene serine/threonine kinase 17b Neighboring gene MPRA-validated peak4000 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16900 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:197124217-197125416 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16901 Neighboring gene HECW2 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:197183033-197183534 Neighboring gene RNA, 7SL, cytoplasmic 820, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16902 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16903 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16904 Neighboring gene Sharpr-MPRA regulatory region 6737 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:197269708-197269898 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16905 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16906 Neighboring gene uncharacterized LOC105373822 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16907 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16908 Neighboring gene uncharacterized LOC105373821 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16909 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12204 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12205 Neighboring gene uncharacterized LOC105373823 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16910 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16911 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:197504225-197504762 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:197504763-197505300 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:197517516-197518164 Neighboring gene small Cajal body-specific RNA 16 Neighboring gene coiled-coil domain containing 150

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Decreased expression of NEDL2 in Hirschsprung's disease. O'Donnell AM, et al. J Pediatr Surg, 2016 Nov. PMID 27430863
    2. Mutations in HECW2 are associated with intellectual disability and epilepsy. Halvardson J, et al. J Med Genet, 2016 Oct. PMID 27334371, Free PMC Article
    3. The Nedd4 family of E3 ubiquitin ligases: functional diversity within a common modular architecture. Ingham RJ, et al. Oncogene, 2004 Mar 15. PMID 15021885
    4. HECW2-related disorder in four Japanese patients. Yanagishita T, et al. Am J Med Genet A, 2021 Oct. PMID 34047014
    5. Delineating the genotypic and phenotypic spectrum of HECW2-related neurodevelopmental disorders. Acharya A, et al. J Med Genet, 2022 Jul. PMID 34321324

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Delineating the genotypic and phenotypic spectrum of HECW2-related neurodevelopmental disorders.
      Title: Delineating the genotypic and phenotypic spectrum of HECW2-related neurodevelopmental disorders.
    2. Circ_0057583 facilitates brain microvascular endothelial cell injury through modulating miR-204-5p/NR4A1 axis.
      Title: Circ_0057583 facilitates brain microvascular endothelial cell injury through modulating miR-204-5p/NR4A1 axis.
    3. A novel likely pathogenic heterozygous HECW2 missense variant in a family with variable expressivity of neurodevelopmental delay, hypotonia, and epileptiform EEG patterns.
      Title: A novel likely pathogenic heterozygous HECW2 missense variant in a family with variable expressivity of neurodevelopmental delay, hypotonia, and epileptiform EEG patterns.
    4. HECW2-related disorder in four Japanese patients.
      Title: HECW2-related disorder in four Japanese patients.
    5. Association of HECW2 variants with developmental and epileptic encephalopathy and knockdown of zebrafish hecw2a.
      Title: Association of HECW2 variants with developmental and epileptic encephalopathy and knockdown of zebrafish hecw2a.
    6. Ectopic expression of HECW2 causes the ubiquitination of HP1alpha and beta, thereby targeting them for proteasomal degradation.
      Title: E3 ubiquitin ligase HECW2 mediates the proteasomal degradation of HP1 isoforms.
    7. Results show that HECW2 interacts with two lamin A-binding proteins: proliferating cell nuclear antigen (PCNA), via a canonical PCNA-interacting protein (PIP) motif, and lamin B1. HECW2 mediates their ubiquitination and targets them for proteasomal degradation.
      Title: E3 ubiquitin ligase HECW2 targets PCNA and lamin B1.
    8. HECW2, a novel EC ubiquitin E3 ligase, plays a critical role in stabilizing endothelial cell-to-cell junctions by regulating AMOT-like 1 (AMOTL1) stability.
      Title: The endothelial E3 ligase HECW2 promotes endothelial cell junctions by increasing AMOTL1 protein stability via K63-linked ubiquitination.
    9. HECW2 is an ubiquitin ligase that stabilises p73, a crucial mediator of neurodevelopment and neurogenesis. This study implicates pathogenic genetic variants in HECW2 as potential causes of neurodevelopmental disorders in humans.
      Title: De novo missense variants in HECW2 are associated with neurodevelopmental delay and hypotonia.
    10. This work lends further support to previously identified candidate gene HECW2 as a novel candidate gene in intellectual disability and epilepsy. In 39 patient-parent trios, 29 de novo mutations in coding sequence were identified.
      Title: Mutations in HECW2 are associated with intellectual disability and epilepsy.
    Submit: New GeneRIF Correction See all GeneRIFs (13)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Neurodevelopmental disorder with hypotonia, seizures, and absent language
    MedGen: C4310643 OMIM: 617268 GeneReviews: Not available
    		Compare labs

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • DKFZp686M17164

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of dendrite morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of mitotic metaphase/anaphase transition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitotic spindle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase HECW2
    Names
    HECT-type E3 ubiquitin transferase HECW2
    NEDD4-like E3 ubiquitin-protein ligase 2
    NEDD4-related E3 ubiquitin ligase NEDL2
    NP_001291769.1
    NP_001335697.1
    NP_065811.1
    XP_006712709.1
    XP_006712711.1
    XP_024308788.1
    XP_024308789.1
    XP_047301150.1
    XP_047301151.1
    XP_047301152.1
    XP_047301153.1
    XP_047301154.1
    XP_054199152.1
    XP_054199153.1
    XP_054199154.1
    XP_054199155.1
    XP_054199156.1
    XP_054199157.1
    XP_054199158.1
    XP_054199159.1
    XP_054199160.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_053156.2 RefSeqGene

      Range
      5000..404482
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001304840.3 → NP_001291769.1  E3 ubiquitin-protein ligase HECW2 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC020571, AC074090
      UniProtKB/TrEMBL
      A0A2C9F2N4
      Conserved Domains (4) summary
      pfam06390
      Location:108 → 275
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00119
      Location:884 → 1213
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:860 → 1214
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00397
      Location:453 → 482
      WW; WW domain

    2. NM_001348768.2 → NP_001335697.1  E3 ubiquitin-protein ligase HECW2 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate exon in the 5' UTR, compared to variant 1. Both variants 1 and 3 encode the same isoform (1).
      Source sequence(s)
      AC020571, AC068544, AC074090
      Consensus CDS
      CCDS33354.1
      UniProtKB/Swiss-Prot
      B8ZZB4, Q17RT5, Q68DF8, Q9NPS9, Q9P2P5
      Related
      ENSP00000495418.1, ENST00000644978.2
      Conserved Domains (8) summary
      pfam06390
      Location:464 → 631
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      cd08691
      Location:185 → 321
      C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
      smart00456
      Location:987 → 1018
      WW; Domain with 2 conserved Trp (W) residues
      PHA03169
      Location:584 → 794
      PHA03169; hypothetical protein; Provisional
      cd00078
      Location:1216 → 1570
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00397
      Location:809 → 838
      WW; WW domain
      pfam16562
      Location:45 → 162
      HECW_N; N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
      pfam18436
      Location:915 → 981
      HECW1_helix; Helical box domain of E3 ubiquitin-protein ligase HECW1

    3. NM_020760.4 → NP_065811.1  E3 ubiquitin-protein ligase HECW2 isoform 1

      See identical proteins and their annotated locations for NP_065811.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Both variants 1 and 3 encode the same isoform (1).
      Source sequence(s)
      AC020571, AC068544, AC074090
      Consensus CDS
      CCDS33354.1
      UniProtKB/Swiss-Prot
      B8ZZB4, Q17RT5, Q68DF8, Q9NPS9, Q9P2P5
      Related
      ENSP00000260983.2, ENST00000260983.8
      Conserved Domains (8) summary
      pfam06390
      Location:464 → 631
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      cd08691
      Location:185 → 321
      C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
      smart00456
      Location:987 → 1018
      WW; Domain with 2 conserved Trp (W) residues
      PHA03169
      Location:584 → 794
      PHA03169; hypothetical protein; Provisional
      cd00078
      Location:1216 → 1570
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00397
      Location:809 → 838
      WW; WW domain
      pfam16562
      Location:45 → 162
      HECW_N; N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
      pfam18436
      Location:915 → 981
      HECW1_helix; Helical box domain of E3 ubiquitin-protein ligase HECW1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      196194072..196593554 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006712646.4 → XP_006712709.1  E3 ubiquitin-protein ligase HECW2 isoform X1

      UniProtKB/TrEMBL
      A0A2R8Y6F3
      Conserved Domains (6) summary
      pfam06390
      Location:471 → 638
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      cd08691
      Location:185 → 321
      C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
      PHA03169
      Location:591 → 801
      PHA03169; hypothetical protein; Provisional
      cd00078
      Location:1223 → 1577
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00397
      Location:816 → 845
      WW; WW domain
      pfam16562
      Location:45 → 164
      HECW_N; N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2

    2. XM_047445197.1 → XP_047301153.1  E3 ubiquitin-protein ligase HECW2 isoform X2

      UniProtKB/Swiss-Prot
      B8ZZB4, Q17RT5, Q68DF8, Q9NPS9, Q9P2P5

    3. XM_024453020.2 → XP_024308788.1  E3 ubiquitin-protein ligase HECW2 isoform X1

      UniProtKB/TrEMBL
      A0A2R8Y6F3
      Related
      ENSP00000495504.1, ENST00000644030.1
      Conserved Domains (6) summary
      pfam06390
      Location:471 → 638
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      cd08691
      Location:185 → 321
      C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
      PHA03169
      Location:591 → 801
      PHA03169; hypothetical protein; Provisional
      cd00078
      Location:1223 → 1577
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00397
      Location:816 → 845
      WW; WW domain
      pfam16562
      Location:45 → 164
      HECW_N; N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2

    4. XM_024453021.2 → XP_024308789.1  E3 ubiquitin-protein ligase HECW2 isoform X1

      UniProtKB/TrEMBL
      A0A2R8Y6F3
      Conserved Domains (6) summary
      pfam06390
      Location:471 → 638
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      cd08691
      Location:185 → 321
      C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
      PHA03169
      Location:591 → 801
      PHA03169; hypothetical protein; Provisional
      cd00078
      Location:1223 → 1577
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00397
      Location:816 → 845
      WW; WW domain
      pfam16562
      Location:45 → 164
      HECW_N; N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2

    5. XM_047445198.1 → XP_047301154.1  E3 ubiquitin-protein ligase HECW2 isoform X2

      UniProtKB/Swiss-Prot
      B8ZZB4, Q17RT5, Q68DF8, Q9NPS9, Q9P2P5

    6. XM_047445195.1 → XP_047301151.1  E3 ubiquitin-protein ligase HECW2 isoform X1

      UniProtKB/TrEMBL
      A0A2R8Y6F3

    7. XM_047445196.1 → XP_047301152.1  E3 ubiquitin-protein ligase HECW2 isoform X2

      UniProtKB/Swiss-Prot
      B8ZZB4, Q17RT5, Q68DF8, Q9NPS9, Q9P2P5

    8. XM_047445194.1 → XP_047301150.1  E3 ubiquitin-protein ligase HECW2 isoform X1

      UniProtKB/TrEMBL
      A0A2R8Y6F3

    9. XM_006712648.5 → XP_006712711.1  E3 ubiquitin-protein ligase HECW2 isoform X3

      Conserved Domains (7) summary
      pfam06390
      Location:340 → 507
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      cd08691
      Location:54 → 190
      C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
      smart00119
      Location:1116 → 1445
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:1092 → 1446
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00397
      Location:685 → 714
      WW; WW domain
      pfam12446
      Location:556 → 651
      DUF3682; Protein of unknown function (DUF3682)
      pfam16562
      Location:1 → 33
      HECW_N; N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      196678133..197077648 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054343177.1 → XP_054199152.1  E3 ubiquitin-protein ligase HECW2 isoform X1

      UniProtKB/TrEMBL
      A0A2R8Y6F3

    2. XM_054343184.1 → XP_054199159.1  E3 ubiquitin-protein ligase HECW2 isoform X2

      UniProtKB/Swiss-Prot
      B8ZZB4, Q17RT5, Q68DF8, Q9NPS9, Q9P2P5

    3. XM_054343179.1 → XP_054199154.1  E3 ubiquitin-protein ligase HECW2 isoform X1

      UniProtKB/TrEMBL
      A0A2R8Y6F3

    4. XM_054343178.1 → XP_054199153.1  E3 ubiquitin-protein ligase HECW2 isoform X1

      UniProtKB/TrEMBL
      A0A2R8Y6F3

    5. XM_054343183.1 → XP_054199158.1  E3 ubiquitin-protein ligase HECW2 isoform X2

      UniProtKB/Swiss-Prot
      B8ZZB4, Q17RT5, Q68DF8, Q9NPS9, Q9P2P5

    6. XM_054343181.1 → XP_054199156.1  E3 ubiquitin-protein ligase HECW2 isoform X1

      UniProtKB/TrEMBL
      A0A2R8Y6F3

    7. XM_054343180.1 → XP_054199155.1  E3 ubiquitin-protein ligase HECW2 isoform X1

      UniProtKB/TrEMBL
      A0A2R8Y6F3

    8. XM_054343182.1 → XP_054199157.1  E3 ubiquitin-protein ligase HECW2 isoform X2

      UniProtKB/Swiss-Prot
      B8ZZB4, Q17RT5, Q68DF8, Q9NPS9, Q9P2P5

    9. XM_054343185.1 → XP_054199160.1  E3 ubiquitin-protein ligase HECW2 isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9P2P5.2 GenPept UniProtKB/Swiss-Prot:Q9P2P5

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