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    NPIPA1 nuclear pore complex interacting protein family member A1 [ Homo sapiens (human) ]

    Gene ID: 9284, updated on 28-Oct-2024

    Summary

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    Official Symbol
    NPIPA1provided by HGNC
    Official Full Name
    nuclear pore complex interacting protein family member A1provided by HGNC
    Primary source
    HGNC:HGNC:7909
    See related
    Ensembl:ENSG00000183426 MIM:606406; AllianceGenome:HGNC:7909
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NPIP; NPIPA; morpheus
    Summary
    Predicted to be involved in mRNA transport and protein transport. Predicted to be located in nuclear membrane. Predicted to be part of nuclear pore. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in skin (RPKM 56.3), ovary (RPKM 53.3) and 25 other tissues See more
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    Genomic context

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    See NPIPA1 in Genome Data Viewer
    Location:
    16p13.11
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (14937443..14952056)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (14938510..14953106)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (15031300..15045913)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene PKD1P3-NPIPA1 readthrough Neighboring gene uncharacterized LOC100288162 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:15023765-15024578 Neighboring gene microRNA 6511a-1 Neighboring gene polycystin 1, transient receptor potential channel interacting pseudogene 3 Neighboring gene microRNA 6770-1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:15041221-15041722 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:15041723-15042222 Neighboring gene Sharpr-MPRA regulatory region 4661 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:15068201-15068964 Neighboring gene pyridoxal dependent decarboxylase domain containing 1 Neighboring gene KIAA2013 pseudogene Neighboring gene microRNA 1972-1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Effects of lysophosphatidyl choline and phospholipase A on the lens. Cotlier E, et al. Invest Ophthalmol, 1975 Sep. PMID 1158635
    2. Positive selection of a gene family during the emergence of humans and African apes. Johnson ME, et al. Nature, 2001 Oct 4. PMID 11586358
    3. Novel retinal and cone photoreceptor transcripts revealed by human macular expression profiling. Hornan DM, et al. Invest Ophthalmol Vis Sci, 2007 Dec. PMID 18055785
    4. Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. Loftus BJ, et al. Genomics, 1999 Sep 15. PMID 10493829
    5. A whole genome screen for HIV restriction factors. Liu L, et al. Retrovirology, 2011 Nov 14. PMID 22082156, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of nuclear pore complex interacting protein (NPIP) by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N PubMed
    Knockdown of nuclear pore complex interacting protein (NPIP) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Readthrough PKD1P3-NPIPA1

    Readthrough gene: PKD1P3-NPIPA1, Included gene: PKD1P3

    Homology

    Clone Names

    • FLJ42525, FLJ44848

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in mRNA transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of nuclear pore IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    nuclear pore complex-interacting protein family member A1
    Names
    nuclear pore complex-interacting protein A type

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006985.4 → NP_008916.2  nuclear pore complex-interacting protein family member A1

      See identical proteins and their annotated locations for NP_008916.2

      Status: VALIDATED

      Source sequence(s)
      AC138932, KF175225
      Consensus CDS
      CCDS10557.1
      UniProtKB/Swiss-Prot
      O15102, Q9UND3
      UniProtKB/TrEMBL
      A0A067ZUL9
      Related
      ENSP00000331843.6, ENST00000328085.10
      Conserved Domains (1) summary
      pfam06409
      Location:22 → 287
      NPIP; Nuclear pore complex interacting protein (NPIP)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      14937443..14952056
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_187607.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      776873..791391
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054329176.1 → XP_054185151.1  nuclear pore complex-interacting protein family member A1 isoform X3

    2. XM_054329173.1 → XP_054185148.1  nuclear pore complex-interacting protein family member A1 isoform X1

    3. XM_054329174.1 → XP_054185149.1  nuclear pore complex-interacting protein family member A1 isoform X2

    4. XM_045181393.2 → XP_045037328.1  nuclear pore complex-interacting protein family member A1 isoform X1

    5. XM_054329175.1 → XP_054185150.1  nuclear pore complex-interacting protein family member A1 isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      14938510..14953106
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9UND3.3 GenPept UniProtKB/Swiss-Prot:Q9UND3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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