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    AVL9 Avl9p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850805, updated on 18-Sep-2024

    Summary

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    Official Symbol
    AVL9
    Official Full Name
    Avl9p
    Primary source
    SGD:S000004104
    Locus tag
    YLR114C
    See related
    AllianceGenome:SGD:S000004104; FungiDB:YLR114C; VEuPathDB:YLR114C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in post-Golgi vesicle-mediated transport. Located in cellular bud neck; cellular bud tip; and cytoplasm. Orthologous to human AVL9 (AVL9 cell migration associated). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See AVL9 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (374944..377238, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase HOG1 Neighboring gene tRNA-Arg Neighboring gene cleavage polyadenylation factor subunit CFT2 Neighboring gene mRNA splicing protein MSL5

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Avl9p, a member of a novel protein superfamily, functions in the late secretory pathway. Harsay E, et al. Mol Biol Cell, 2007 Apr. PMID 17229886, Free PMC Article
    2. Sequence analysis of a 37.6 kbp cosmid clone from the right arm of Saccharomyces cerevisiae chromosome XII, carrying YAP3, HOG1, SNR6, tRNA-Arg3 and 23 new open reading frames, among which several homologies to proteins involved in cell division control and to mammalian growth factors and other animal proteins are found. Verhasselt P, et al. Yeast, 1997 Mar 15. PMID 9090053
    3. The synaptobrevin homologue Snc2p recruits the exocyst to secretory vesicles by binding to Sec6p. Shen D, et al. J Cell Biol, 2013 Aug 5. PMID 23897890, Free PMC Article
    4. A Rab escort protein integrates the secretion system with TOR signaling and ribosome biogenesis. Singh J, et al. Genes Dev, 2009 Aug 15. PMID 19684114, Free PMC Article
    5. Local control of phosphatidylinositol 4-phosphate signaling in the Golgi apparatus by Vps74 and Sac1 phosphoinositide phosphatase. Wood CS, et al. Mol Biol Cell, 2012 Jul. PMID 22553352, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. AVL9 plays role in Golgi apparatus and exocytosis
      Title: Avl9p, a member of a novel protein superfamily, functions in the late secretory pathway.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in post-Golgi vesicle-mediated transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cellular bud neck HDA PubMed 
    located_in cellular bud tip HDA PubMed 
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Avl9p
    NP_013215.1
    • Conserved protein involved in exocytic transport from the Golgi; mutation is synthetically lethal with apl2 vps1 double mutation; member of a protein superfamily with orthologs in diverse organisms; relocalizes from bud neck to cytoplasm upon DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      374944..377238 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182001.1 → NP_013215.1  TPA: Avl9p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013215.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VYB2, Q12500
      UniProtKB/TrEMBL
      A7A116, B3LT79, C7GQD7, G2WIV6, N1NZN1
      Conserved Domains (1) summary
      pfam09794
      Location:9 → 401
      Avl9; Transport protein Avl9
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12500.1

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