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    GHRLOS ghrelin opposite strand/antisense RNA [ Homo sapiens (human) ]

    Gene ID: 100126793, updated on 17-Sep-2024

    Summary

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    Official Symbol
    GHRLOSprovided by HGNC
    Official Full Name
    ghrelin opposite strand/antisense RNAprovided by HGNC
    Primary source
    HGNC:HGNC:33885
    See related
    Ensembl:ENSG00000240288 MIM:618445; AllianceGenome:HGNC:33885
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GHRLAS; GHRL-AS1; NCRNA00068
    Summary
    This gene is an antisense gene of the ghrelin/obestatin prepropeptide gene. Alternatively spliced transcript variants have been identified and they may function as non-coding regulatory RNAs. [provided by RefSeq, Jan 2013]
    Expression
    Ubiquitous expression in stomach (RPKM 13.1), bone marrow (RPKM 11.6) and 24 other tissues See more
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    Genomic context

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    See GHRLOS in Genome Data Viewer
    Location:
    3p25.3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (10280952..10293449)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (10274251..10286748)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (10322636..10335133)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene interleukin 1 receptor associated kinase 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:10266988-10267770 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19421 Neighboring gene Sharpr-MPRA regulatory region 8698 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:10275792-10276394 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14057 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14058 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:10290711-10291579 Neighboring gene 3p25 TatD DNase domain containing 2 Alu-mediated recombination region Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14059 Neighboring gene Sharpr-MPRA regulatory region 7129 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:10329829-10330444 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:10332275-10332877 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19422 Neighboring gene TatD DNase domain containing 2 Neighboring gene Sharpr-MPRA regulatory region 4342 Neighboring gene long intergenic non-protein coding RNA 852 Neighboring gene microRNA 12127 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:10362509-10363104 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:10369968-10370516 Neighboring gene ghrelin and obestatin prepropeptide Neighboring gene SEC13 homolog, nuclear pore and COPII coat complex component Neighboring gene microRNA 378b Neighboring gene ATPase plasma membrane Ca2+ transporting 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Revised genomic structure of the human ghrelin gene and identification of novel exons, alternative splice variants and natural antisense transcripts. Seim I, et al. BMC Genomics, 2007 Aug 30. PMID 17727735, Free PMC Article
    2. Complex organisation and structure of the ghrelin antisense strand gene GHRLOS, a candidate non-coding RNA gene. Seim I, et al. BMC Mol Biol, 2008 Oct 28. PMID 18954468, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    General gene information

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    Markers

    Potential readthrough

    Included gene: TATDN2

    Other Names

    • GHRL antisense RNA 1 (non-protein coding)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_033090.2 RefSeqGene

      Range
      5001..17498
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. NR_004431.3 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) is represented as non-coding because it lacks a supported ORF.
      Source sequence(s)
      BM991802, EU789528, EU789531, EU789538
      Related
      ENST00000439539.3

    2. NR_024144.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate exon and uses an alternate splice site, compared to variant 1.
      Source sequence(s)
      BM991802, EU789528, EU789531, EU789545

    3. NR_024145.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains two alternate exons and lacks an alternate exon, compared to variant 1.
      Source sequence(s)
      BM991802, EU789528, EU789531, EU789537

    4. NR_073566.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) contains two alternate exons and uses an alternate splice site, compared to variant 1.
      Source sequence(s)
      BM991802, EU789528, EU789531, EU789543

    5. NR_073567.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) contains an alternate exon and uses two alternate splice sites, compared to variant 1.
      Source sequence(s)
      BM991802, EU789528, EU789531, EU789544

    6. NR_073568.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) contains an alternate exon and uses an alternate splice site, compared to variant 1.
      Source sequence(s)
      BM991802, EU789528, EU789531, EU789535

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      10280952..10293449
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      10274251..10286748
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NR_024146.1: Suppressed sequence

      Description
      NR_024146.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
    Nucleotide Protein
    Heading Accession and Version

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