cnp1 centromere-specific histone H3 CENP-A [Schizosaccharomyces pombe (fission yeast)] - Gene

Summary

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Official Symbol: cnp1
Official Full Name: centromere-specific histone H3 CENP-A
Primary source: PomBase:SPBC1105.17
Locus tag: SPOM_SPBC1105.17
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Schizosaccharomyces pombe (strain: 972h-)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as: sim2
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Genomic context

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See cnp1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 1

Sequence:: Chromosome: II; NC_003423.3 (3538504..3540163)

Chromosome II - NC_003423.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003423.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Set2 regulates Ccp1 and Swc2 to ensure centromeric stability by retargeting CENP-A.
Title: Set2 regulates Ccp1 and Swc2 to ensure centromeric stability by retargeting CENP-A.
Direct recruitment of Mis18 to interphase spindle pole bodies promotes CENP-A chromatin assembly.
Title: Direct recruitment of Mis18 to interphase spindle pole bodies promotes CENP-A chromatin assembly.
GRANT Motif Regulates CENP-A Incorporation and Restricts RNA Polymerase II Accessibility at Centromere.
Title: GRANT Motif Regulates CENP-A Incorporation and Restricts RNA Polymerase II Accessibility at Centromere.
The chromatin remodeler RSC prevents ectopic CENP-A propagation into pericentromeric heterochromatin at the chromatin boundary.
Title: The chromatin remodeler RSC prevents ectopic CENP-A propagation into pericentromeric heterochromatin at the chromatin boundary.
N-Terminus Does Not Govern Protein Turnover of Schizosaccharomyces pombe CENP-A.
Title: N-Terminus Does Not Govern Protein Turnover of Schizosaccharomyces pombe CENP-A.
During S phase, histone H3 is deposited as a placeholder at fission yeast centromeres and is subsequently evicted in G2, when the authors detected deposition of the majority of new CENP-A(Cnp1).
Title: Centromere DNA Destabilizes H3 Nucleosomes to Promote CENP-A Deposition during the Cell Cycle.
CENP-A loading chaperone Sim3 requires genomic stability-regulating site within CENP-A N-terminus prolines for binding; prolyl isomerization of the CENP-A N-terminus regulates centromeric integrity in fission yeast.
Title: Prolyl isomerization of the CENP-A N-terminus regulates centromeric integrity in fission yeast.
Despite the lack of sequence conservation, Schizosaccharomyces centromere DNA possesses intrinsic conserved properties that promote assembly of CENP-A chromatin.
Title: Interspecies conservation of organisation and function between nonhomologous regional centromeres.
Ccp1 modulates epigenetic stability at centromeres and affects heterochromatin distribution in Schizosaccharomyces pombe.
Title: Ccp1 modulates epigenetic stability at centromeres and affects heterochromatin distribution in Schizosaccharomyces pombe.
These findings suggest that protection of CENP-A from degradation by heterochromatin is a general mechanism used for centromere assembly, and also provide novel insights into centromere evolution.
Title: Heterochromatin and RNAi regulate centromeres by protecting CENP-A from ubiquitin-mediated degradation.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by PomBase

Function	Evidence Code	Pubs
enables centromeric DNA binding	ISM Inferred from Sequence Model more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural constituent of chromatin	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in CENP-A containing chromatin assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in CENP-A containing chromatin	IDA Inferred from Direct Assay more info	PubMed
part_of CENP-A containing nucleosome	NAS Non-traceable Author Statement more info
is_active_in chromatin	IDA Inferred from Direct Assay more info	PubMed
is_active_in chromosome, centromeric core domain	IDA Inferred from Direct Assay more info	PubMed
is_active_in chromosome, centromeric region	IDA Inferred from Direct Assay more info	PubMed
is_active_in condensed chromosome, centromeric region	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: centromere-specific histone H3 CENP-A

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003423.3 Reference assembly

Range

3538504..3540163

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001022392.3 → NP_596473.1 centromere-specific histone H3 CENP-A [Schizosaccharomyces pombe]

See identical proteins and their annotated locations for NP_596473.1

Status: PROVISIONAL

UniProtKB/Swiss-Prot

Q9Y812

Conserved Domains (2) summary

pfam00125
Location:1 → 118

Histone; Core histone H2A/H2B/H3/H4

cl23735
Location:19 → 119

H4; Histone H4, one of the four histones, along with H2A, H2B and H3, which forms the eukaryotic nucleosome core; along with H3, it plays a central role in nucleosome formation; histones bind to DNA and wrap the genetic material into "beads on a string" in ...