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    pyp2 protein tyrosine phosphatase Pyp2 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2542200, updated on 18-Sep-2024

    Summary

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    Official Symbol
    pyp2
    Official Full Name
    protein tyrosine phosphatase Pyp2
    Primary source
    PomBase:SPAC19D5.01
    Locus tag
    SPOM_SPAC19D5.01
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See pyp2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_003424.3 (5202656..5205202)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene retrotransposable element/transposon Tf2-type Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene protein Emc10 Neighboring gene terminal uridylyltransferase Cid1 Neighboring gene E3 ubiquitin-protein ligase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Control of Sty1 MAPK activity through stabilisation of the Pyp2 MAPK phosphatase. Kowalczyk KM, et al. J Cell Sci, 2013 Aug 1. PMID 23690545
    2. The role of the RACK1 ortholog Cpc2p in modulating pheromone-induced cell cycle arrest in fission yeast. Mos M, et al. PLoS One, 2013. PMID 23843946, Free PMC Article
    3. Activation and regulation of the Spc1 stress-activated protein kinase in Schizosaccharomyces pombe. Degols G, et al. Mol Cell Biol, 1996 Jun. PMID 8649397, Free PMC Article
    4. Fission yeast Tor1 functions as part of TORC1 to control mitotic entry through the stress MAPK pathway following nutrient stress. Hartmuth S, et al. J Cell Sci, 2009 Jun 1. PMID 19417002
    5. Active nucleocytoplasmic shuttling required for function and regulation of stress-activated kinase Spc1/StyI in fission yeast. Gaits F, et al. Mol Biol Cell, 1999 May. PMID 10233152, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables MAP kinase tyrosine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables MAP kinase tyrosine phosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of p38MAPK cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of p38MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol HDA PubMed 
    is_active_in mitochondrion HDA PubMed 
    is_active_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    protein tyrosine phosphatase Pyp2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      5202656..5205202
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001020328.3 → NP_594899.1  protein tyrosine phosphatase Pyp2 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_594899.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P32586, Q9UR59, Q9UU64
      Conserved Domains (3) summary
      COG5599
      Location:405 → 709
      COG5599; Protein tyrosine phosphatase [Signal transduction mechanisms]
      cd00047
      Location:461 → 697
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd01446
      Location:4 → 129
      DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...
    Nucleotide Protein
    Heading Accession and Version

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