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    wpl1 WAPL family protein [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2540860, updated on 18-Sep-2024

    Summary

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    Official Symbol
    wpl1
    Official Full Name
    WAPL family protein
    Primary source
    PomBase:SPBC428.17c
    Locus tag
    SPOM_SPBC428.17C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See wpl1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    3
    Sequence:
    Chromosome: II; NC_003423.3 (474574..476728, complement)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Obg-like ATPase Neighboring gene 1-acylglycerol-3-phosphate acyltransferase Neighboring gene ncRNA Neighboring gene Rheb GTPase Rhb1 Neighboring gene ncRNA Neighboring gene DNA replication licensing factor Cdt1 Neighboring gene U3 snoRNP protein Utp15

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Rec8 Cohesin-mediated Axis-loop chromatin architecture is required for meiotic recombination. Sakuno T, et al. Nucleic Acids Res, 2022 Apr 22. PMID 35333350, Free PMC Article
    2. Cell-cycle regulation of cohesin stability along fission yeast chromosomes. Bernard P, et al. EMBO J, 2008 Jan 9. PMID 18079700, Free PMC Article
    3. Psm3 acetylation on conserved lysine residues is dispensable for viability in fission yeast but contributes to Eso1-mediated sister chromatid cohesion by antagonizing Wpl1. Feytout A, et al. Mol Cell Biol, 2011 Apr. PMID 21300781, Free PMC Article
    4. DNA Topoisomerase II modulates acetyl-regulation of cohesin-mediated chromosome dynamics. Lin SJ, et al. Curr Genet, 2017 Oct. PMID 28382430, Free PMC Article
    5. Pds5 Regulates Sister-Chromatid Cohesion and Chromosome Bi-orientation through a Conserved Protein Interaction Module. Goto Y, et al. Curr Biol, 2017 Apr 3. PMID 28343969

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Psm3 acetylation contributes to Eso1 counteracting of Wpl1 to secure stable cohesin interaction with postreplicative chromosomes
      Title: Psm3 acetylation on conserved lysine residues is dispensable for viability in fission yeast but contributes to Eso1-mediated sister chromatid cohesion by antagonizing Wpl1.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables ATP hydrolysis activity IC
    Inferred by Curator
    more info
    		  
    enables ATP-dependent protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cohesin unloader activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables cohesin unloader activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin looping IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in homologous chromosome pairing at meiosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic sister chromatid cohesion EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in mitotic sister chromatid cohesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mitotic sister chromatid cohesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Wpl/Pds5 cohesin loading/unloading complex EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in nuclear chromosome IC
    Inferred by Curator
    more info
    		 PubMed 
    is_active_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    WAPL family protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      474574..476728 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001021102.3 → NP_595195.1  WAPL family protein [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_595195.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O94364, Q9USF1
      Conserved Domains (1) summary
      pfam07814
      Location:161 → 467
      WAPL; Wings apart-like protein regulation of heterochromatin
    Nucleotide Protein
    Heading Accession and Version

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