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    pub3 HECT-type ubiquitin-protein ligase Pub3 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2539956, updated on 18-Sep-2024

    Summary

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    Official Symbol
    pub3
    Official Full Name
    HECT-type ubiquitin-protein ligase Pub3
    Primary source
    PomBase:SPBC16E9.11c
    Locus tag
    SPOM_SPBC16E9.11C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See pub3 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    2
    Sequence:
    Chromosome: II; NC_003423.3 (1935530..1938570, complement)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene AAA family ATPase Rix7 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene poly(A)-binding protein Pab2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. CSN facilitates Cullin-RING ubiquitin ligase function by counteracting autocatalytic adapter instability. Wee S, et al. Nat Cell Biol, 2005 Apr. PMID 15793566
    2. E3 ubiquitin ligase Pub1 is implicated in endocytosis of a GPI-anchored protein Ecm33 in fission yeast. Fang Y, et al. PLoS One, 2014. PMID 24454826, Free PMC Article
    3. Regulation of mRNA Levels by Decay-Promoting Introns that Recruit the Exosome Specificity Factor Mmi1. Kilchert C, et al. Cell Rep, 2015 Dec 22. PMID 26670050, Free PMC Article
    4. Significant conservation of synthetic lethal genetic interaction networks between distantly related eukaryotes. Dixon SJ, et al. Proc Natl Acad Sci U S A, 2008 Oct 28. PMID 18931302, Free PMC Article
    5. Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast. Roguev A, et al. Science, 2008 Oct 17. PMID 18818364, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Ubiquitin-Protein Ligase is known to bind COP9 signalosome.
      Title: CSN facilitates Cullin-RING ubiquitin ligase function by counteracting autocatalytic adapter instability.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables phospholipid binding ISM
    Inferred from Sequence Model
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    HECT-type ubiquitin-protein ligase Pub3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      1935530..1938570 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001021694.3 → NP_595793.1  HECT-type ubiquitin-protein ligase Pub3 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_595793.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O14326, P79055
      Conserved Domains (5) summary
      cd08382
      Location:7 → 130
      C2_Smurf-like; C2 domain present in Smad ubiquitination-related factor (Smurf)-like proteins
      smart00456
      Location:365 → 397
      WW; Domain with 2 conserved Trp (W) residues
      COG5021
      Location:4 → 786
      HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
      cd00078
      Location:434 → 784
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00397
      Location:308 → 337
      WW; WW domain
    Nucleotide Protein
    Heading Accession and Version

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